Optimization of the process parameters for the fabrication of a polymer coated layered double hydroxide-methotrexate nanohybrid for the possible treatment of osteosarcoma

RSC Advances ◽  
2015 ◽  
Vol 5 (124) ◽  
pp. 102574-102592 ◽  
Author(s):  
Sayantan Ray ◽  
Akhilesh Mishra ◽  
Tapan Kumar Mandal ◽  
Biswanath Sa ◽  
Jui Chakraborty
Keyword(s):  
Layered Double Hydroxide ◽  
Process Parameters ◽  
Double Hydroxide

The study demonstrates the method of optimization for the development of PLGA encapsulated LDH-MTX, MTX and their in vitro and in vivo evaluation.

Synthesis and Characterization of Dual Radiolabeled Layered Double Hydroxide Nanoparticles for Use in In Vitro and In Vivo Nanotoxicology Studies

2009 ◽  
Vol 114 (2) ◽  
pp. 734-740 ◽  
Author(s):  
Anthony W. Musumeci ◽  
Tara L. Schiller ◽  
Zhi Ping Xu ◽  
Rodney F. Minchin ◽  
Darren J. Martin ◽  
...  
Keyword(s):  
Layered Double Hydroxide ◽  
Synthesis And Characterization ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

Radioisotope Co-57 incorporated layered double hydroxide nanoparticles as a cancer imaging agent

RSC Advances ◽  
2016 ◽  
Vol 6 (54) ◽  
pp. 48415-48419 ◽  
Author(s):  
Tae-Hyun Kim ◽  
Jun Young Lee ◽  
Min-Kyu Kim ◽  
Jeong Hoon Park ◽  
Jae-Min Oh
Keyword(s):  
Layered Double Hydroxide ◽  
Cellular Uptake ◽  
Tumor Targeting ◽  
Cancer Imaging ◽  
Imaging Agent ◽  
Isomorphous Substitution ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

Radioisotope Co-57 substituted LDH were successfully prepared by isomorphous substitution and showed high in vitro cellular uptake and tumor targeting in vivo biodistribution.

scholarly journals Physicochemical Properties and Hematocompatibility of Layered Double Hydroxide-Based Anticancer Drug Methotrexate Delivery System

Pharmaceutics ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 1210
Author(s):  
Sang-Yong Jung ◽  
Hyoung-Mi Kim ◽  
Soonjae Hwang ◽  
Do-Gak Jeung ◽  
Ki-Jong Rhee ◽  
...  
Keyword(s):  
Particle Size ◽  
Layered Double Hydroxide ◽  
Anticancer Drug ◽  
Delivery System ◽  
Blood Cells ◽  
Hydrodynamic Radius ◽  
Hydrothermal Reaction ◽  
Membrane Damage ◽  
Double Hydroxide

A layered double hydroxide (LDH)-based anticancer delivery system was investigated in terms of crystalline phase, particle size, hydrodynamic radius, zeta potential, etc. through in vitro and in vivo study. Size controlled LDH with anticancer drug methotrexate (MTX) incorporation was successfully prepared through step-by-step hydrothermal reaction and ion-exchange reaction. The MTX-LDH was determined to have a neutral surface charge and strong agglomeration in the neutral aqueous condition due to the surface adsorbed MTX; however, the existence of proteins in the media dramatically reduced agglomeration, resulting in the hydrodynamic radius of MTX-LDH being similar to the primary particle size. The protein fluorescence quenching assay exhibited that MTX readily reduced the fluorescence of proteins, suggesting that the interaction between MTX and proteins was strong. On the other hand, MTX-LDH showed much less binding constant to proteins compared with MTX, implying that the protein interaction of MTX was effectively blocked by the LDH carrier. The in vivo hemolysis assay after intravenous injection of MTX-LDH showed neither significant reduction in red blood cell number nor membrane damage. Furthermore, the morphology of red blood cells in a mouse model did not change upon MTX-LDH injection. Scanning electron microscopy showed that the MTX-LDH particles were attached on the blood cells without serious denaturation of cellular morphology, taking advantage of the cell hitchhiking property.

Preparation of Glycy-l-Tyrosine intercalated layered double hydroxide film and its in vitro release behavior

2010 ◽  
Vol 157 (2-3) ◽  
pp. 598-604 ◽  
Author(s):  
Xianggui Kong ◽  
Shuxian Shi ◽  
Jingbin Han ◽  
Fengjie Zhu ◽  
Min Wei ◽  
...  
Keyword(s):  
Layered Double Hydroxide ◽  
In Vitro Release ◽  
Release Behavior ◽  
Hydroxide Film ◽  
Double Hydroxide ◽  
Vitro Release

The effect of nanonization on poorly water soluble glibenclamide using a liquid anti-solvent precipitation technique: aqueous solubility, in vitro and in vivo study

RSC Advances ◽  
2015 ◽  
Vol 5 (99) ◽  
pp. 81728-81738 ◽  
Author(s):  
Rohan D. Deshpande ◽  
Gowda D. V. ◽  
Naga Sravan Kumar Varma Vegesna ◽  
Rudra Vaghela ◽  
Kulkarni P. K.
Keyword(s):  
Process Parameters ◽  
Oral Bioavailability ◽  
Aqueous Solubility ◽  
Water Soluble ◽  
In Vivo Study ◽  
Precipitation Technique ◽  
Poorly Water Soluble

In the present study, efforts were made to optimize the process parameters of LAS technique for developing GLB NPs, in order to enhance the aqueous solubility as well as oral bioavailability.

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