Poly(γ-glutamic acid)-stabilized iron oxide nanoparticles: synthesis, characterization and applications for MR imaging of tumors

RSC Advances ◽  
2015 ◽  
Vol 5 (94) ◽  
pp. 76700-76707 ◽  
Author(s):  
Zhibo Yu ◽  
Chen Peng ◽  
Yu Luo ◽  
Jianzhi Zhu ◽  
Chen Chen ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Glutamic Acid ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Nanoparticles Synthesis ◽  
Mild Reduction ◽  
One Step

Poly(γ-glutamic acid)-stabilized iron oxide nanoparticles can be formed via a one-step mild reduction for MR imaging of tumors.

scholarly journals Intrinsically Germanium-69-Labeled Iron Oxide Nanoparticles: Synthesis and In-Vivo Dual-Modality PET/MR Imaging

2014 ◽  
Vol 26 (30) ◽  
pp. 5119-5123 ◽  
Author(s):  
Rubel Chakravarty ◽  
Hector F. Valdovinos ◽  
Feng Chen ◽  
Christina M. Lewis ◽  
Paul A. Ellison ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Dual Modality ◽  
Nanoparticles Synthesis

A Magnetic Sensor Based on Poly(γ-Glutamic Acid)-Functionalized Iron Oxide Nanoparticles for Cr3+ Detection.

2021 ◽  
Vol 17 ◽  
Author(s):  
Zhibo Yu ◽  
Liang Jia ◽  
Jianzhi Zhu ◽  
Mingwu Shen ◽  
Jingchao Li ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Glutamic Acid ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Water Environment ◽  
Transverse Relaxation Time ◽  
Oxide Nanoparticles ◽  
Fe3o4 Nps ◽  
Signal Change ◽  
Mild Reduction

Background: The highly sensitive and selective detection of Cr3+ is critical. Objective: We report the development of poly(γ-glutamic acid) (γ-PGA)-functionalized iron oxide nanoparticles (γ-PGA-Fe3O4 NPs) as a magnetic nanosensor for magnetic resonance (MR) detection of trivalent chromium (Cr3+) in aqueous solution. Methods: The γ-PGA-Fe3O4 NPs with a mean particle size of 7.3 nm, good colloidal stability and ultrahigh r2 relaxivity (326.8 mM−1s−1) were synthesized via a facile mild reduction approach in the presence of γ-PGA, and used for MR detection of Cr3+. Results: Upon exposure to Cr3+, the γ-PGA-Fe3O4 NPs aggregated into nanoclusters as verified by dynamic light scattering due to the coordination of Cr3+ with γ-PGA side chain carboxyl groups, resulting in the decrease in their transverse relaxation time. This MR signal change enables detection of Cr3+ in a concentration range of 0.4-1 nM. We also show that the γ-PGA-Fe3O4 NPs have an excellent selectivity toward Cr3+ and a high recovery percentage of 83.8% or above. Conclusion: This study thus demonstrates that the developed γ-PGA-Fe3O4 NPs may be used as a nanoprobe for MR sensing of Cr3+ in water environment.

scholarly journals Macrophage-Laden Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Enhanced Dual-Mode CT/MR Imaging of Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 995
Author(s):  
Yucheng Peng ◽  
Xiaomeng Wang ◽  
Yue Wang ◽  
Yue Gao ◽  
Rui Guo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Pamam Dendrimer ◽  
Great Promise ◽  
Oxide Nanoparticles ◽  
Dual Mode ◽  
Gold Nanoflowers ◽  
Average Size

The design of multimodal imaging nanoplatforms with improved tumor accumulation represents a major trend in the current development of precision nanomedicine. To this end, we report herein the preparation of macrophage (MA)-laden gold nanoflowers (NFs) embedded with ultrasmall iron oxide nanoparticles (USIO NPs) for enhanced dual-mode computed tomography (CT) and magnetic resonance (MR) imaging of tumors. In this work, generation 5 poly(amidoamine) (G5 PAMAM) dendrimer-stabilized gold (Au) NPs were conjugated with sodium citrate-stabilized USIO NPs to form hybrid seed particles for the subsequent growth of Au nanoflowers (NFs). Afterwards, the remaining terminal amines of dendrimers were acetylated to form the dendrimer-stabilized Fe3O4/Au NFs (for short, Fe3O4/Au DSNFs). The acquired Fe3O4/Au DSNFs possess an average size around 90 nm, display a high r1 relaxivity (1.22 mM−1 s−1), and exhibit good colloidal stability and cytocompatibility. The created hybrid DSNFs can be loaded within MAs without producing any toxicity to the cells. Through the mediation of MAs with a tumor homing and immune evasion property, the Fe3O4/Au DSNFs can be delivered to tumors more efficiently than those without MAs after intravenous injection, thus significantly improving the MR/CT imaging performance of tumors. The developed MA-mediated delivery system may hold great promise for enhanced tumor delivery of other contrast agents or nanomedicines for precision cancer nanomedicine applications.

Facile One‐Step Synthesis of Polyoxazoline‐Coated Iron Oxide Nanoparticles

2018 ◽  
Vol 3 (42) ◽  
pp. 11898-11901 ◽  
Author(s):  
Pierre Venturini ◽  
Solenne Fleutot ◽  
Franck Cleymand ◽  
Thomas Hauet ◽  
Jean‐Charles Dupin ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
One Step

LAPONITE®-stabilized iron oxide nanoparticles for in vivo MR imaging of tumors

2016 ◽  
Vol 4 (3) ◽  
pp. 474-482 ◽  
Author(s):  
Ling Ding ◽  
Yong Hu ◽  
Yu Luo ◽  
Jianzhi Zhu ◽  
Yilun Wu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Coprecipitation Method ◽  
Oxide Nanoparticles

LAPONITE®-stabilized iron oxide nanoparticles with great colloidal stability and high T2 relaxivity are synthesized by a facile controlled coprecipitation method, and can significantly enhance the contrast of tumors in vivo, indicating their tremendous potential in MR imaging applications.

DNA-Grafted Poly(acrylic acid) for One-Step DNA Functionalization of Iron Oxide Nanoparticles

Langmuir ◽  
2018 ◽  
Vol 34 (47) ◽  
pp. 14342-14346 ◽  
Author(s):  
Xiaole Hu ◽  
Chan-Jin Kim ◽  
Shine K. Albert ◽  
So-Jung Park
Keyword(s):  
Iron Oxide ◽  
Acrylic Acid ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
One Step ◽  
Poly Acrylic Acid ◽  
Dna Functionalization
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