A liquid chromatography electrospray ionization tandem mass spectrometric study (LC/ESI-MS/MS) of in vivo metabolites of cisplatin in rat liver and brain tissues: deuterated experiments

RSC Advances ◽  
2015 ◽  
Vol 5 (109) ◽  
pp. 89951-89958
Author(s):  
Raju Bandu ◽  
Hak Jin Kim ◽  
Hyuck Jun Mok ◽  
Kwang Pyo Kim

In vivo rat liver and brain tissue metabolites of an anticancer drug, cisplatin, have been identified and characterized by using LC/ESI-MS/MS in combination with on-line H/D exchange experiments.

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