Navigating in chromone chemical space: discovery of novel and distinct A3 adenosine receptor ligands

RSC Advances ◽  
2015 ◽  
Vol 5 (96) ◽  
pp. 78572-78585 ◽  
Author(s):  
F. Cagide ◽  
A. Gaspar ◽  
J. Reis ◽  
D. Chavarria ◽  
S. Vilar ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Chemical Space ◽  
Receptor Subtype ◽  
Receptor Ligands ◽  
Specific Receptor ◽  
A3 Adenosine Receptor ◽  
Adenosine Receptor Ligands ◽  
Effective Drugs

One of the major hurdles in the development of effective drugs targeting GPCRs is finding ligands selective for a specific receptor subtype. Here we describe a potent and selective hormone-based hA3 AR ligand (Ki of 167 nM) with a remarkable selectivity.

Recent Advances on QSAR-Based Profiling of Agonist and Antagonist A3 Adenosine Receptor Ligands

2013 ◽  
Vol 13 (9) ◽  
pp. 1048-1068 ◽  
Author(s):  
Changliang Deng ◽  
Feng Luan ◽  
Maykel Cruz- Monteagudo ◽  
Fernanda Borges ◽  
M. Natalia D. S. Cordeiro
Keyword(s):  
Adenosine Receptor ◽  
Receptor Ligands ◽  
Recent Advances ◽  
A3 Adenosine Receptor ◽  
Agonist And Antagonist ◽  
Adenosine Receptor Ligands

A3 Adenosine Receptor Ligands: History and Perspectives

2000 ◽  
Vol 20 (2) ◽  
pp. 103-128 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Barbara Cacciari ◽  
Romeo Romagnoli ◽  
Stefania Merighi ◽  
Katia Varani ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Receptor Ligands ◽  
A3 Adenosine Receptor ◽  
Adenosine Receptor Ligands

scholarly journals Erratum to: Molecular modelling study of 2-phenylethynyladenosine (PEAdo) derivatives as highly selective A3 adenosine receptor ligands

2006 ◽  
Vol 3 (1-2) ◽  
pp. 181-181
Author(s):  
Diego Dal Ben ◽  
Catia Lambertucci ◽  
Sara Taffi ◽  
Sauro Vittori ◽  
Rosaria Volpini ◽  
...  
Keyword(s):  
Molecular Modelling ◽  
Adenosine Receptor ◽  
Receptor Ligands ◽  
A3 Adenosine Receptor ◽  
Adenosine Receptor Ligands ◽  
Modelling Study

ChemInform Abstract: A3 Adenosine Receptor Ligands: History and Perspectives

ChemInform ◽  
2010 ◽  
Vol 31 (20) ◽  
pp. no-no
Author(s):  
Pier Giovanni Baraldi ◽  
Barbara Cacciari ◽  
Romeo Romagnoli ◽  
Stefania Merighi ◽  
Katia Varani ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Receptor Ligands ◽  
A3 Adenosine Receptor ◽  
Adenosine Receptor Ligands

Progress in the development of small molecules as new human A3 adenosine receptor ligands based on the 3-thiophenylcoumarin core

MedChemComm ◽  
2016 ◽  
Vol 7 (5) ◽  
pp. 845-852 ◽  
Author(s):  
M. J. Matos ◽  
S. Vilar ◽  
S. Kachler ◽  
S. Vazquez-Rodriguez ◽  
C. Varela ◽  
...  
Keyword(s):  
Small Molecules ◽  
Adenosine Receptor ◽  
Docking Studies ◽  
Receptor Ligands ◽  
A3 Adenosine Receptor ◽  
Adenosine Receptor Ligands

3-Thiophenylcoumarins are described as adenosine receptor ligands. Synthesis, in vitro pharmacological assays and docking studies were performed.

Design and Synthesis of A3 Adenosine Receptor Ligands, 2′-Fluoro Analogues of Cl-IB-MECA

ChemInform ◽  
2004 ◽  
Vol 35 (5) ◽  
Author(s):  
Hea Ok Kim ◽  
Jae Gyu Park ◽  
Hyung Ryong Moon ◽  
Prashantha Gunaga ◽  
Moo Hong Lim ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Receptor Ligands ◽  
Design And Synthesis ◽  
A3 Adenosine Receptor ◽  
Adenosine Receptor Ligands
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