Facile and expedient access to bis-coumarin–iminothiazole hybrids by molecular hybridization approach: synthesis, molecular modelling and assessment of alkaline phosphatase inhibition, anticancer and antileishmanial potential

RSC Advances ◽  
2015 ◽  
Vol 5 (109) ◽  
pp. 89919-89931 ◽  
Author(s):  
Aliya Ibrar ◽  
Sumera Zaib ◽  
Imtiaz Khan ◽  
Farukh Jabeen ◽  
Jamshed Iqbal ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Molecular Modelling ◽  
Molecular Hybridization ◽  
Phosphatase Inhibition ◽  
Potential Inhibitors ◽  
Alkaline Phosphatase Inhibition

A series of new cytotoxic bis-coumarin–iminothiazole hybrids was developed as potential inhibitors of alkaline phosphatase and leishmaniasis.

Influence of the diversified structural variations at the imine functionality of 4-bromophenylacetic acid derived hydrazones on alkaline phosphatase inhibition: synthesis and molecular modelling studies

RSC Advances ◽  
2015 ◽  
Vol 5 (110) ◽  
pp. 90806-90818 ◽  
Author(s):  
Imtiaz Khan ◽  
Aliya Ibrar ◽  
Syeda Abida Ejaz ◽  
Shafi Ullah Khan ◽  
Syed Jawad Ali Shah ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Molecular Modelling ◽  
Binding Mode ◽  
Structural Variations ◽  
Molecular Modelling Studies ◽  
Modelling Studies ◽  
Phosphatase Inhibition ◽  
Alkaline Phosphatase Inhibition

Putative binding mode of 4g inside the active pocket of h-PLAP.

Synthesis, alkaline phosphatase inhibition studies and molecular docking of novel derivatives of 4-quinolones

2017 ◽  
Vol 126 ◽  
pp. 408-420 ◽  
Author(s):  
Mariia Miliutina ◽  
Syeda Abida Ejaz ◽  
Shafi Ullah Khan ◽  
Viktor O. Iaroshenko ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Molecular Docking ◽  
Phosphatase Inhibition ◽  
Inhibition Studies ◽  
Derivatives Of ◽  
Alkaline Phosphatase Inhibition
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