A Ru(iii) – catalyzed α-cross-coupling aldol type addition reaction of activated olefins with isatins

RSC Advances ◽  
2016 ◽  
Vol 6 (3) ◽  
pp. 1705-1709 ◽  
Author(s):  
A. Sanjeeva Kumar ◽  
Palakuri Ramesh ◽  
G. Santosh Kumar ◽  
A. Swetha ◽  
Jagadeesh Babu Nanubolu ◽  
...  
Keyword(s):  
Room Temperature ◽  
Addition Reaction ◽  
Cross Coupling ◽  
Tributyltin Hydride ◽  
Activated Olefins

A α-cross-coupling aldol type addition reaction activated olefins with isatins has been described in the presence of ruthenium(iii) chloride and tributyltin hydride (TBTH) at room temperature.

ChemInform Abstract: A Ru(III) - Catalyzed α-Cross-Coupling Aldol Type Addition Reaction of Activated Olefins with Isatins.

ChemInform ◽  
2016 ◽  
Vol 47 (21) ◽  
Author(s):  
A. Sanjeeva Kumar ◽  
Palakuri Ramesh ◽  
G. Santosh Kumar ◽  
A. Swetha ◽  
Jagadeesh Babu Nanubolu ◽  
...  
Keyword(s):  
Addition Reaction ◽  
Cross Coupling ◽  
Activated Olefins

Indium/Fe(iii) – mediated regioselective β-cross-coupling aldol type addition reaction of activated alkenes with isatins/isatinimines in aqueous media

RSC Advances ◽  
2015 ◽  
Vol 5 (64) ◽  
pp. 51581-51585 ◽  
Author(s):  
A. Sanjeeva Kumar ◽  
Palakuri Ramesh ◽  
G. Santosh Kumar ◽  
Jagadeesh Babu Nanubolu ◽  
T. Prabhakar Rao ◽  
...  
Keyword(s):  
Room Temperature ◽  
Addition Reaction ◽  
Aqueous Media ◽  
Cross Coupling ◽  
Highly Efficient

A highly efficient and regioselective β-cross coupling aldol type addition reaction of activated alkenes with isatin/isatinimine derivatives in the presence of Indium/Fe(iii) in THF/H2O at room temperature is described.

The Merger of CF3SO2Na and Palladium Catalysis to Enable Decarboxylative Cross-Coupling for the Synthesis of Aromatic Ketones under Room Temperature

2021 ◽  
Author(s):  
Pan Xie ◽  
Cheng Xue ◽  
Cancan Wang ◽  
Dongdong Du ◽  
Sanshan Shi
Keyword(s):  
Visible Light ◽  
Room Temperature ◽  
Palladium Catalysis ◽  
Cross Coupling ◽  
Boronic Acids ◽  
Aromatic Ketones ◽  
Aryl Ketones ◽  
Oxocarboxylic Acids

A CF3SO2Na/Pd(OAc)2 co-catalyzed strategy is developed to produce aryl ketones via visible-light-induced decarboxylative cross-coupling of α-oxocarboxylic acids and aryl boronic acids. This process was perfomed under air at room temperature,...

scholarly journals Synthesis and Antiproliferative Evaluation of 2-Deoxy-N-glycosylbenzotriazoles/imidazoles

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3742
Author(s):  
Caleigh S. Garton ◽  
Noelle K. DeRose ◽  
Dylan Dominguez ◽  
Maria L. Turbi-Henderson ◽  
Ashley L. Lehr ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Addition Reaction ◽  
Protecting Group ◽  
Human Breast ◽  
Lung Cancer Cell ◽  
Subsequent Removal ◽  
Anticancer Properties ◽  
Tributyltin Hydride ◽  
High Yields

A series of 2-deoxy-2-iodo-α-d-mannopyranosylbenzotriazoles was synthesized using the benzyl, 4,6-benzylidene and acetyl protected D-glucal in the presence of N-iodosuccinimide (NIS). Subsequent removal of the iodine at the C-2 position using tributyltin hydride under free radical conditions afforded the 2-deoxy-α-d-glucopyranosylbenzotriazoles in moderate to high yields. This method was extended to the preparation of substituted 2-deoxy-β-d-glucopyranosylimidazoles as well. The stereoselectivity of the addition reaction and the effect of the protecting group and temperature on anomer distribution of the benzotriazole series were also investigated. The anticancer properties of the newly synthesized compounds were evaluated in a series of viability studies using HeLa (human cervical adenocarcinoma), human breast and lung cancer cell lines. The N-[3,4,6-tri-O-benzyl-2-deoxy-α-d-glucopyranosyl]-1H-benzotriazole and the N-[3,4,6-tri-O-acetyl-2-deoxy-α-d-glucopyranosyl]-2H-benzotriazole were found to be the most potent cancer cell inhibitors at 20 µM concentrations across all four cell lines.

scholarly journals Synthesis of Network Polymers by Means of Addition Reactions of Multifunctional-Amine and Poly(ethylene glycol) Diglycidyl Ether or Diacrylate Compounds

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2047
Author(s):  
Naofumi Naga ◽  
Mitsusuke Sato ◽  
Kensuke Mori ◽  
Hassan Nageh ◽  
Tamaki Nakano
Keyword(s):  
Ethylene Glycol ◽  
Room Temperature ◽  
Addition Reaction ◽  
Monomer Concentration ◽  
Diglycidyl Ether ◽  
Porous Polymers ◽  
Addition Reactions ◽  
Poly Ethylene Glycol ◽  
Network Polymers ◽  
Poly Ethylene

Addition reactions of multi-functional amine, polyethylene imine (PEI) or diethylenetriamine (DETA), and poly(ethylene glycol) diglycidyl ether (PEGDE) or poly(ethylene glycol) diacrylate (PEGDA), have been investigated to obtain network polymers in H2O, dimethyl sulfoxide (DMSO), and ethanol (EtOH). Ring opening addition reaction of the multi-functional amine and PEGDE in H2O at room temperature or in DMSO at 90 °C using triphenylphosphine as a catalyst yielded gels. Aza-Michael addition reaction of the multi-functional amine and PEGDA in DMSO or EtOH at room temperature also yielded corresponding gels. Compression test of the gels obtained with PEI showed higher Young’s modulus than those with DETA. The reactions of the multi-functional amine and low molecular weight PEGDA in EtOH under the specific conditions yielded porous polymers induced by phase separation during the network formation. The morphology of the porous polymers could be controlled by the reaction conditions, especially monomer concentration and feed ratio of the multi-functional amine to PEGDA of the reaction system. The porous structure was formed by connected spheres or a co-continuous monolithic structure. The porous polymers were unbreakable by compression, and their Young’s modulus increased with the increase in the monomer concentration of the reaction systems. The porous polymers absorbed various solvents derived from high affinity between the polyethylene glycol units in the network structure and the solvents.

Room-Temperature, Water-Promoted, Radical-Coupling Reactions of Phenols with tert-Butyl Nitrite

Synlett ◽  
2017 ◽  
Vol 28 (16) ◽  
pp. 2153-2156 ◽  
Author(s):  
Wen-Ting Wei ◽  
Hongze Liang ◽  
Wen-Ming Zhu ◽  
Weida Liang ◽  
Yi Wu ◽  
...  
Keyword(s):  
Room Temperature ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Phenol Derivative ◽  
Tert Butyl ◽  
Radical Coupling ◽  
Air Atmosphere ◽  
Cross Coupling Reaction ◽  
Temperature Water

A radical–radical cross-coupling reaction of phenols with tert-butyl nitrite has been developed with the use of water as an additive. This method allows the construction of C–N bonds under an air atmosphere at room temperature, providing the ortho-nitrated phenol derivative in moderate to good yields.

Palladium-catalyzed Mizoroki–Heck-type reactions of [Ph2SRfn][OTf] with alkenes at room temperature

2016 ◽  
Vol 52 (80) ◽  
pp. 11893-11896 ◽  
Author(s):  
Shi-Meng Wang ◽  
Hai-Xia Song ◽  
Xiao-Yan Wang ◽  
Nan Liu ◽  
Hua-Li Qin ◽  
...  
Keyword(s):  
Room Temperature ◽  
Cross Coupling ◽  
Palladium Catalyzed

The first Pd-catalyzed Mizoroki–Heck-type cross-coupling of phenylsulfonium salts with alkenes was disclosed at room temperature.

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