Heparin-modified graphene oxide loading anti-cancer drug and growth factor with heat stability, long-term release property and lower cytotoxicity

RSC Advances ◽  
2015 ◽  
Vol 5 (102) ◽  
pp. 84334-84342 ◽  
Author(s):  
Ting Wu ◽  
Bin Zhang ◽  
Yuanyuan Liang ◽  
Tao Liu ◽  
Jinyan Bu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Growth Factor ◽  
Heat Stability ◽  
Cancer Drug ◽  
Cancer Drugs ◽  
Modified Graphene Oxide ◽  
Anti Cancer ◽  
Release Property ◽  
Modified Graphene

Heparin-modified graphene oxide was prepared as the carrier of anti-cancer drugs and growth factor with long-term release property, reduced cytotoxicity and improved heat stability.

scholarly journals Long-term stably dispersed functionalized graphene oxide as an oil additive

RSC Advances ◽  
2019 ◽  
Vol 9 (67) ◽  
pp. 39230-39241
Author(s):  
Tianjiao Bao ◽  
Zhiyong Wang ◽  
Yan Zhao ◽  
Yan Wang ◽  
Xiaosu Yi
Keyword(s):  
Graphene Oxide ◽  
Thermal Properties ◽  
Tribological Properties ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Modified Graphene Oxide ◽  
Modified Graphene

T154 modified graphene oxide as an oil additive exhibited excellent tribological properties, long-term stable dispersity and high thermal properties.

Phosphate modified graphene oxide: Long–term biodegradation and cytocompatibility

Carbon ◽  
2019 ◽  
Vol 154 ◽  
pp. 342-349 ◽  
Author(s):  
Anne M. Arnold ◽  
Brian D. Holt ◽  
Caoxin Tang ◽  
Stefanie A. Sydlik
Keyword(s):  
Graphene Oxide ◽  
Modified Graphene Oxide ◽  
Modified Graphene

β-Cyclodextrin modified graphene oxide–magnetic nanocomposite for targeted delivery and pH-sensitive release of stereoisomeric anti-cancer drugs

RSC Advances ◽  
2015 ◽  
Vol 5 (108) ◽  
pp. 89299-89308 ◽  
Author(s):  
Congli Wang ◽  
Bo Li ◽  
Weifen Niu ◽  
Shasha Hong ◽  
Bassam Saif ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Targeted Delivery ◽  
Drug Carrier ◽  
Layer By Layer ◽  
Innovative Drug ◽  
Assembly Method ◽  
Modified Graphene Oxide ◽  
Anti Cancer ◽  
Modified Graphene ◽  
Effective Layer

β-Cyclodextrin modified graphene oxide–magnetic (MGC) nanocomposite as an innovative drug carrier was the first to be developed via an effective layer-by-layer-assembly method.

Doxorubicin Loaded Nanoparticle Consisting of Chitosan and Mannose Modified Graphene Oxide for Intracellular Drug Delivery and Anti-tumor Activity

2020 ◽  
Vol 13 (5) ◽  
pp. 5155-5164
Author(s):  
Meena K. S. ◽  
Sonia K ◽  
Alamelu Bai S
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Release ◽  
Cancer Drug ◽  
Hemolysis Assay ◽  
Functionalized Graphene Oxide ◽  
Intracellular Drug Delivery ◽  
Modified Graphene Oxide

In order to develop the efficiency and the specificity of anticancer drug delivery, we have designed an innovative nanocarrier. The nanocarrier system comprises of a multifunctional graphene oxide nanoparticle-based drug delivery system (GO-CS-M-DOX) as a novel platform for intracellular drug delivery of doxorubicin (DOX). Firstly, graphene oxide (GO) was synthesized by hummer’s method whose surface was functionalized by chitosan (CS) in order to obtain a more precise drug delivery, the system was then decorated with mannose (M). Further conjugation of an anti-cancer drug doxorubicin to the nanocarrier system resulted in GO-CS-M-DOX drug delivery system. The resultant conjugate was characterized for its physio-chemical properties and its biocompatibility was evaluated via hemolysis assay. The drug entrapment efficiency is as high as 90% and in vitro release studies of DOX under pH 5.3 is significantly higher than that under pH 7.4. The anticancer activity of the synthesized drug delivery system was studied by 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay against MCF-7 cell line. These results stated that the pH dependent multifunctional doxorubicin- chitosan functionalized graphene oxide based nanocarrier system, could lead to a promising and potential platform for intracellular delivery and cytotoxicity activity for variety of anticancer drugs.   

Fanconi Anemia DNA Repair Pathway as a New Mechanism to Exploit Cancer Drug Resistance

2020 ◽  
Vol 20 (9) ◽  
pp. 779-787
Author(s):  
Kajal Ghosal ◽  
Christian Agatemor ◽  
Richard I. Han ◽  
Amy T. Ku ◽  
Sabu Thomas ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Dna Repair ◽  
Fanconi Anemia ◽  
Cancer Drug ◽  
Drug Resistant ◽  
Cancer Drugs ◽  
Repair Pathway ◽  
Cancer Drug Resistance ◽  
Anti Cancer ◽  
Cancerous Cells

Chemotherapy employs anti-cancer drugs to stop the growth of cancerous cells, but one common obstacle to the success is the development of chemoresistance, which leads to failure of the previously effective anti-cancer drugs. Resistance arises from different mechanistic pathways, and in this critical review, we focus on the Fanconi Anemia (FA) pathway in chemoresistance. This pathway has yet to be intensively researched by mainstream cancer researchers. This review aims to inspire a new thrust toward the contribution of the FA pathway to drug resistance in cancer. We believe an indepth understanding of this pathway will open new frontiers to effectively treat drug-resistant cancer.

Development of A Novel System Based on Green Magnetic / Graphene Oxide / Chitosan /Allium Sativum / Quercus / Nanocomposite for Targeted Release of Doxorubicin Anti-Cancer Drug

2020 ◽  
Vol 20 (9) ◽  
pp. 1094-1104 ◽  
Author(s):  
Omid Arjmand ◽  
Mehdi Ardjmand ◽  
Ali M. Amani ◽  
Mohmmad H. Eikani
Keyword(s):  
Graphene Oxide ◽  
Allium Sativum ◽  
Cytotoxicity Assay ◽  
Targeted Treatment ◽  
Cancer Drug ◽  
Magnetic Graphene Oxide ◽  
Magnetic Graphene ◽  
Anti Cancer ◽  
Cancerous Cells ◽  
Targeted Release

Background: Doxorubicin, as a strong anti-cancer agent for clinical treatment of various cancer types along with other drugs, is widely utilized. Due to the physiology of the human body and cancerous tissues, the applicability of doxorubicin is still limited and the targeted treatment of the different types of cancers is considered. Also, the side effects of the conventional forms of chemotherapy medicines, damaging and stressing the normal cells are considerable. Objective: This study introduces a novel and effective system for the targeted release of doxorubicin by successfully fabricating the green magnetic graphene oxide, chitosan, allium sativum, and quercus nanocomposite. Methods: The in vitro release of doxorubicin loaded on the nanocomposite was evaluated and investigated at pH 7.4 and 6.5, respectively. The drug diffusivity in the plasma environment was assessed for a more accurate analysis of the drug diffusion process. The nanocomposite loaded drug release mechanism and kinetics, as well as cytotoxicity assay was investigated. Results: The efficiency of the drug encapsulation was significantly enhanced using natural extract ingredients and consequently, the efficacy of the targeted treatment of cancerous tissues was improved. The developed nanocomposite provided a controlled release of doxorubicin in similar acidic conditions of the normal and cancerous cells and affirming that the fabricated system is thoroughly pH-dependent. Conclusion: The cytotoxicity assay confirmed that the fabricated nanocomposite at a high growth rate of cancerous cells has an anticancer property and acts as a toxic agent against tumor cells, suggesting that in conjunction with doxorubicin, it can be highly improved for killing cancerous cells.

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