Transition-metal free synthesis of quinazolinones via tandem cyclization of 2-halobenzoic acids with amidines

RSC Advances ◽  
2015 ◽  
Vol 5 (70) ◽  
pp. 57235-57239 ◽  
Author(s):  
Abhishek R. Tiwari ◽  
Bhalchandra M. Bhanage
Keyword(s):  
Transition Metal ◽  
Metal Free ◽  
Simple Protocol ◽  
Tandem Cyclization

A simple protocol for the synthesis of quinazoline-4(3H)-ones by tandem cyclization of 2-halobenzoic acids with amidines has been developed by using KOH as a base in DMSO at 120 °C.

Highly chemoselective deoxygenation of N-heterocyclic N-oxides under transition metal-free conditions

2021 ◽  
Vol 19 (16) ◽  
pp. 3735-3742
Author(s):  
Se Hyun Kim ◽  
Ju Hyeon An ◽  
Jun Hee Lee
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Eosin Y ◽  
Metal Free ◽  
Simple Protocol

Here, we provide an operationally simple protocol for the highly chemoselective deoxygenation of various functionalized N-heterocyclic N-oxides under visible light-mediated photoredox conditions with Na2-eosin Y as an organophotocatalyst.

scholarly journals Photocatalytic Synthesis of Tetra-Substituted Furans Promoted by Carbon Dioxide

2021 ◽  
Author(s):  
Ya-Ming Tian ◽  
Huaiju Wang ◽  
Ritu Ritu ◽  
Burkhard Koenig
Keyword(s):  
Carbon Dioxide ◽  
Transition Metal ◽  
Visible Light ◽  
Metal Free ◽  
Mild Conditions ◽  
Simple Protocol ◽  
Visible Light Driven ◽  
Substituted Furans ◽  
Photocatalytic Synthesis

We report a simple protocol for the transition metal-free, visible-light-driven conversion of 1,3-diketones to tetra-substituted furan skeleton compounds in carbon dioxide (CO2) atmosphere under mild conditions. It was found that...

Visible-light-induced tandem cyclization of 2-alkynylanilines with disulfides: a convenient method for accessing benzothiophenes under transition-metal-free and photocatalyst-free conditions

2017 ◽  
Vol 15 (36) ◽  
pp. 7678-7684 ◽  
Author(s):  
Xiaoyu Xie ◽  
Pinhua Li ◽  
Qing Shi ◽  
Lei Wang
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Convenient Method ◽  
Metal Free ◽  
Efficient Route ◽  
Tandem Cyclization

An efficient route to benzothiophenes via visible-light induced cyclization of 2-alkynylanilines with disulfides under transition-metal-free and photocatalyst-free conditions was developed.

Polythene glycol (PEG) as a reusable solvent system for the synthesis of 1,3,5-triazines via aerobic oxidative tandem cyclization of benzylamines and N-substituted benzylamines with amidines under transition metal-free conditions

2016 ◽  
Vol 18 (1) ◽  
pp. 144-149 ◽  
Author(s):  
Abhishek R. Tiwari ◽  
Bhalchandra M. Bhanage
Keyword(s):  
Transition Metal ◽  
Solvent System ◽  
Metal Free ◽  
Highly Efficient ◽  
Tandem Cyclization ◽  
Peg 600

A highly efficient protocol for the synthesis of 1,3,5-triazines from benzylamines and amidines in PEG-600 has been developed.

Transition-metal free thiocyanooxygenation of functionalized alkenes: facile routes to SCN-containing dihydrofurans and lactones

2016 ◽  
Vol 14 (11) ◽  
pp. 3098-3104 ◽  
Author(s):  
Li-Na Guo ◽  
Yu-Rui Gu ◽  
Hua Yang ◽  
Jie Hu
Keyword(s):  
Transition Metal ◽  
Economical Method ◽  
Metal Free ◽  
Mild Conditions ◽  
Tandem Cyclization

An efficient transition-metal free tandem cyclization of functionalized alkenes with thiocyanate salts has been developed under mild conditions. This protocol offers a simple, easy-to-handle, and atom-economical method for the synthesis of SCN-containing dihydrofurans and lactones with good to excellent yields.

Transition-Metal-Free Tandem Cyclization/N-Arylation Reaction: A Method To Access Biaryl Sultam Derivatives via a Diradical Pathway

2020 ◽  
Vol 22 (16) ◽  
pp. 6623-6627 ◽  
Author(s):  
Vijaykumar H. Thorat ◽  
Jen-Chieh Hsieh ◽  
Chien-Hong Cheng
Keyword(s):  
Transition Metal ◽  
Metal Free ◽  
Tandem Cyclization

C2-gem-Aryldifluoromethylation of quinoline N-oxides with potassium 2,2-difluoro-2-arylacetates under transition-metal free conditions

Synthesis ◽  
2020 ◽  
Author(s):  
Yanhui Gao ◽  
Laiqiang Li ◽  
jie liu ◽  
Lei Wang ◽  
Min Wang
Keyword(s):  
Transition Metal ◽  
Functional Groups ◽  
Experimental Studies ◽  
Metal Free ◽  
Simple Protocol

A simple protocol for C2-gem-aryldifluoromethylation of quinoline N-oxides with potassium 2,2-difluoro-2-arylacetates has been developed, affording C2-gem-aryldifluoromethylated quinoline N-oxides bearing different functional groups in moderate to good yields. Moreover, experimental studies reveal that this reaction is likely to proceed through a radical pathway.

Base-Catalyzed Tandem Cyclization: Diastereoselective Access to the 3,4-Dihydroisoquinolin-2(1H)-one Core

Synthesis ◽  
2018 ◽  
Vol 51 (06) ◽  
pp. 1473-1481 ◽  
Author(s):  
Harshadas Meshram ◽  
Ravindra Kumbhare ◽  
Prashishkumar Shirsat ◽  
Navnath Khomane ◽  
Sneha Meshram ◽  
...  
Keyword(s):  
Natural Products ◽  
Transition Metal ◽  
Acetylenic Esters ◽  
One Pot ◽  
Direct Construction ◽  
Metal Free ◽  
Diastereoselective Reaction ◽  
Three Component Reaction ◽  
Tandem Cyclization

A novel, one-pot reaction for the synthesis of 3,4-dihydroisoquinolin-2(1H)-one derivatives is developed via a base-mediated three-component reaction of ninhydrin, aniline and acetylenic esters. This diastereoselective reaction takes place in methanol at 70 °C under transition-metal-free conditions, and direct construction of the C–N and C–C bonds is readily achieved via tandem cyclization. These cyclic frameworks are resourceful small molecular keys to many natural products.

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