scholarly journals Staged inertial microfluidic focusing for complex fluid enrichment

RSC Advances ◽  
2015 ◽  
Vol 5 (66) ◽  
pp. 53857-53864 ◽  
Author(s):  
Amy E. Reece ◽  
Kaja Kaastrup ◽  
Hadley D. Sikes ◽  
John Oakey
Keyword(s):  
High Throughput ◽  
High Yield ◽  
Inertial Focusing ◽  
Cellular Assays ◽  
Micro Total Analysis Systems ◽  
Total Analysis ◽  
Complex Fluid

A staged microfluidic inertial focusing device capable of high-yield, high-throughput complex fluid enrichment has been developed for integrated microfluidic cellular assays and biological micro total analysis systems.

scholarly journals Microparticle Inertial Focusing in an Asymmetric Curved Microchannel

Fluids ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. 57 ◽  
Author(s):  
Arzu Özbey ◽  
Mehrdad Karimzadehkhouei ◽  
Hossein Alijani ◽  
Ali Koşar
Keyword(s):  
Biomedical Applications ◽  
Cost Effective ◽  
Label Free ◽  
Promising Technique ◽  
Flow Rates ◽  
Inertial Focusing ◽  
Micro Total Analysis Systems ◽  
Symmetric Geometry ◽  
Total Analysis ◽  
Different Diameters

Inertial Microfluidics offer a high throughput, label-free, easy to design, and cost-effective solutions, and are a promising technique based on hydrodynamic forces (passive techniques) instead of external ones, which can be employed in the lab-on-a-chip and micro-total-analysis-systems for the focusing, manipulation, and separation of microparticles in chemical and biomedical applications. The current study focuses on the focusing behavior of the microparticles in an asymmetric curvilinear microchannel with curvature angle of 280°. For this purpose, the focusing behavior of the microparticles with three different diameters, representing cells with different sizes in the microchannel, was experimentally studied at flow rates from 400 to 2700 µL/min. In this regard, the width and position of the focusing band are carefully recorded for all of the particles in all of the flow rates. Moreover, the distance between the binary combinations of the microparticles is reported for each flow rate, along with the Reynolds number corresponding to the largest distances. Furthermore, the results of this study are compared with those of the microchannel with the same curvature angle but having a symmetric geometry. The microchannel proposed in this study can be used or further modified for cell separation applications.

Microparticle Inertial Focusing in an Asymmetric Curved Microchannel

2018 ◽  
Author(s):  
Arzu Özbey ◽  
Mehrdad Karimzadehkhouei ◽  
Hossein Alijani ◽  
Ali Koşar
Keyword(s):  
Reynolds Number ◽  
Biomedical Applications ◽  
Cost Effective ◽  
Reynolds Numbers ◽  
Band Width ◽  
Label Free ◽  
Inertial Focusing ◽  
Micro Total Analysis Systems ◽  
Total Analysis ◽  
Asymmetric Microchannel

Inertial microfluidics offers high throughput, label-free, easy to design, and cost-effective solutions and is a promising technique based on hydrodynamic forces (passive techniques) instead of external ones, which can be employed in lab-on-a-chip and micro-total-analysis-systems for focusing, manipulation, and separation of microparticles in chemical and biomedical applications. The current work, studies the focusing behavior of microparticles in an asymmetric curvilinear microchannel. For this purpose, focusing behavior, including position and band width, of microparticles of diameters of 10, 15 and 20 µm, which served as representatives of different cells, in an asymmetric curvilinear microchannel with curvature angle of 280° was experimentally studied at flow rates from 400 to 2700 µL/min (corresponding to Reynolds numbers between 30 and 205). The results revealed that the largest distance between focusing bands of 20 µm and 10 µm microparticles as well as between focusing bands of 15 µm and 10 µm was obtained at Reynolds number of 121. For the case of microparticles of diameters 20 µm and 15 µm, the largest distance was seen at Reynolds number of 144. The focusing band width became smaller in the asymmetric microchannel so that focusing could be more clearly observed in this configuration.

scholarly journals Design of Low-Cost and High-Strength Titanium Alloys Using Pseudo-Spinodal Mechanism through Diffusion Couple Technology and CALPHAD

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 2910
Author(s):  
Chaoyi Ding ◽  
Chun Liu ◽  
Ligang Zhang ◽  
Di Wu ◽  
Libin Liu
Keyword(s):  
Diffusion Couple ◽  
Titanium Alloys ◽  
High Throughput ◽  
Volume Fraction ◽  
Raw Materials ◽  
Low Cost ◽  
High Strength ◽  
High Yield ◽  
Α Phase ◽  
Cr System

The high cost of development and raw materials have been obstacles to the widespread use of titanium alloys. In the present study, the high-throughput experimental method of diffusion couple combined with CALPHAD calculation was used to design and prepare the low-cost and high-strength Ti-Al-Cr system titanium alloy. The results showed that ultra-fine α phase was obtained in Ti-6Al-10.9Cr alloy designed through the pseudo-spinodal mechanism, and it has a high yield strength of 1437 ± 7 MPa. Furthermore, application of the 3D strength model of Ti-6Al-xCr alloy showed that the strength of the alloy depended on the volume fraction and thickness of the α phase. The large number of α/β interfaces produced by ultra-fine α phase greatly improved the strength of the alloy but limited its ductility. Thus, we have demonstrated that the pseudo-spinodal mechanism combined with high-throughput diffusion couple technology and CALPHAD was an efficient method to design low-cost and high-strength titanium alloys.

scholarly journals Glass based Micro Total Analysis Systems: Materials, Fabrication methods, and Applications

2021 ◽  
pp. 129859
Author(s):  
Tao Tang ◽  
Yapeng Yuan ◽  
Yaxiaer Yalikun ◽  
Yochiroh Hosokawa ◽  
Ming Li ◽  
...  
Keyword(s):  
Micro Total Analysis Systems ◽  
Total Analysis
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