Evaluation and optimization of biomarkers in a primary dysmenorrhea model using ultra performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry combined with a support vector machine

RSC Advances ◽  
2015 ◽  
Vol 5 (73) ◽  
pp. 59564-59569 ◽  
Author(s):  
Ling Fang ◽  
Xinyu Liu ◽  
Zhenzhu Zhang ◽  
Aizhu Li ◽  
Haoyue Deng ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Metabolic Profiling ◽  
Ultra Performance Liquid Chromatography ◽  
Support Vector ◽  
Primary Dysmenorrhea ◽  
Analysis Method ◽  
Flight Mass Spectrometry ◽  
Metabolic Profiling Analysis ◽  
Profiling Analysis ◽  
Potential Biomarkers

A plasma metabolic profiling analysis method was established to find and optimize the potential biomarkers of a primary dysmenorrhea model.

scholarly journals Metabolic profiling putatively identifies plasma biomarkers of male infertility using UPLC-ESI-IT-TOFMS

RSC Advances ◽  
2018 ◽  
Vol 8 (46) ◽  
pp. 25974-25982 ◽  
Author(s):  
F. J. Zeng ◽  
H. C. Ji ◽  
Z. M. Zhang ◽  
J. K. Luo ◽  
H. M. Lu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Male Infertility ◽  
Electrospray Ionization ◽  
Metabolic Profiling ◽  
Ion Trap ◽  
Time Of Flight ◽  
Ultra Performance Liquid Chromatography ◽  
Flight Mass Spectrometry ◽  
Potential Biomarkers

Ultra-performance liquid chromatography-electrospray ionization-ion trap-time of flight mass spectrometry combined with chemometrics methods was used to discover potential biomarkers of male infertility based on untargeted plasma metabolomics.

Screening and verification of linearly dependent biomarkers with acute toxicity induced by Aconiti Radix based on liquid chromatography-mass spectrometry-based metabolite profiling

RSC Advances ◽  
2015 ◽  
Vol 5 (126) ◽  
pp. 103915-103924 ◽  
Author(s):  
Yubo Li ◽  
Zhiguo Hou ◽  
Yuming Wang ◽  
Lei Wang ◽  
Liang Ju ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Acute Toxicity ◽  
Linear Dependence ◽  
Metabolic Profiling ◽  
Metabolite Profiling ◽  
Liquid Chromatography Mass Spectrometry ◽  
Toxicity Biomarkers ◽  
Metabolic Profiling Analysis ◽  
Profiling Analysis

We built a method that has three parts: first is to screen the biomarkers with metabolic profiling analysis; second is to determine the linear dependence with acute toxicity biomarkers; third is to validate the biomarkers with different Aconiti Radix involved medicine.

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