Antitumor potential of anethole singly and in combination with cyclophosphamide in murine Sarcoma-180 transplantable tumor model

RSC Advances ◽  
2015 ◽  
Vol 5 (70) ◽  
pp. 56549-56559 ◽  
Author(s):  
Samarjit Jana ◽  
Kartick Patra ◽  
Gopeswar Mukherjee ◽  
Shamee Bhattacharjee ◽  
Deba Prasad Mandal
Keyword(s):  
Side Effect ◽  
Tumor Model ◽  
Sarcoma 180 ◽  
Transplantable Tumor ◽  
Antitumor Potential ◽  
Murine Sarcoma

Coupling anethole with cyclophosphamide reduces side effect of the latter and enhances apoptosis–necrosis ratio in murine s-180 tumor model.

scholarly journals Antitumor Potential of Lippia citriodora Essential Oil in Breast Tumor-Bearing Mice

Antioxidants ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 875
Author(s):  
Katerina Spyridopoulou ◽  
Tamara Aravidou ◽  
Evangeli Lampri ◽  
Eleni Effraimidou ◽  
Aglaia Pappa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Antiproliferative Activity ◽  
Folk Medicine ◽  
Tumor Model ◽  
Flowering Plant ◽  
Antitumor Effects ◽  
Lippia Citriodora ◽  
Antitumor Potential ◽  
Apoptotic Marker

Lippia citriodora is a flowering plant cultivated for its lemon-scented leaves and used in folk medicine for the preparation of tea for the alleviation of symptoms of gastrointestinal disorders, cold, and asthma. The oil extracted from the plant leaves was shown to possess antioxidant potential and to exert antiproliferative activity against breast cancer. The aim of this study was to further investigate potential antitumor effects of L. citriodora oil (LCO) on breast cancer. The in vitro antiproliferative activity of LCO was examined against murine DA3 breast cancer cells by the sulforhodamine B assay. We further explored the LCO’s pro-apoptotic potential with the Annexin-PI method. The LCO’s anti-migratory effect was assessed by the wound-healing assay. LCO was found to inhibit the growth of DA3 cells in vitro, attenuate their migration, and induce apoptosis. Finally, oral administration of LCO for 14 days in mice inhibited by 55% the size of developing tumors in the DA3 murine tumor model. Noteworthy, in the tumor tissue of LCO-treated mice the apoptotic marker cleaved caspase-3 was elevated, while a reduced protein expression of survivin was observed. These results indicate that LCO, as a source of bioactive compounds, has a very interesting nutraceutical potential.

scholarly journals A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights

2017 ◽  
Vol 53 (1) ◽  
pp. 134-137 ◽  
Author(s):  
D. Montagner ◽  
B. Fresch ◽  
K. Browne ◽  
V. Gandin ◽  
A. Erxleben
Keyword(s):  
Tumor Model ◽  
Translocator Protein ◽  
Tumor Mass ◽  
Cu Complex ◽  
Murine Tumor ◽  
Murine Tumor Model ◽  
Antitumor Potential

A Cu complex targeting the translocator protein induces a 98% reduction of tumor mass in a murine tumor model.

Corrigendum to “Effect of metformin and adriamycin on transplantable tumor model” [Tissue Cell 47 (2015) 498–505]

2016 ◽  
Vol 48 (5) ◽  
pp. 566
Author(s):  
Ahmed M. Kabel ◽  
Mohamed S. Omar ◽  
Mohamed F. Balaha ◽  
Hany M. Borg
Keyword(s):  
Tumor Model ◽  
Tissue Cell ◽  
Transplantable Tumor

scholarly journals Radiosensitizing Effect of Electrochemotherapy in a Fractionated Radiation Regimen in Radiosensitive Murine Sarcoma and Radioresistant Adenocarcinoma Tumor Model

2009 ◽  
Vol 172 (6) ◽  
pp. 677-685 ◽  
Author(s):  
Simona Kranjc ◽  
Gregor Tevz ◽  
Urska Kamensek ◽  
Suzana Vidic ◽  
Maja Cemazar ◽  
...  
Keyword(s):  
Tumor Model ◽  
Radiosensitizing Effect ◽  
Murine Sarcoma ◽  
Fractionated Radiation

Antitumorigenic Potential of Linalool Is Accompanied by Modulation of Oxidative Stress: An In Vivo Study in Sarcoma-180 Solid Tumor Model

2014 ◽  
Vol 66 (5) ◽  
pp. 835-848 ◽  
Author(s):  
Samarjit Jana ◽  
Kartick Patra ◽  
Shehnaz Sarkar ◽  
Jagannath Jana ◽  
Gopeswar Mukherjee ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Solid Tumor ◽  
Tumor Model ◽  
In Vivo Study ◽  
Sarcoma 180 ◽  
Solid Tumor Model

scholarly journals Perillyl Alcohol in Solid Lipid Nanoparticles (SLN-PA): Cytotoxicity and Antitumor Potential in Sarcoma 180 Mice Model

2020 ◽  
Author(s):  
Luciana N. Andrade ◽  
Mariana S. S. Cavendish ◽  
Salvana P. M. Costa ◽  
Ricardo G. Amaral ◽  
Cristiane B. Corrêa ◽  
...  
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Perillyl Alcohol ◽  
Sarcoma 180 ◽  
Mice Model ◽  
Solid Lipid ◽  
Antitumor Potential

Effect of metformin and adriamycin on transplantable tumor model

2015 ◽  
Vol 47 (5) ◽  
pp. 498-505 ◽  
Author(s):  
Ahmed M. Kabel ◽  
Mohamed S. Omar ◽  
Mohamed F. Balaha ◽  
Hany M. Borg
Keyword(s):  
Tumor Model ◽  
Transplantable Tumor
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