Diopside modified porous polyglycolide scaffolds with improved properties

RSC Advances ◽  
2015 ◽  
Vol 5 (68) ◽  
pp. 54822-54829 ◽  
Author(s):  
Pei Feng ◽  
Xiaoning Guo ◽  
Chengde Gao ◽  
Dan Gao ◽  
Tao Xiao ◽  
...  
Keyword(s):  
Selective Laser Sintering ◽  
Biological Properties ◽  
Laser Sintering ◽  
Porous Scaffolds

In this research, diopside was incorporated into PGA scaffolds for enhancing mechanical and biological properties. The porous scaffolds were fabricated via selective laser sintering.

Processing and Characterization of Apatite-Wollastonite Porous Scaffolds for Bone Tissue Engineering

2007 ◽  
Vol 361-363 ◽  
pp. 923-926 ◽  
Author(s):  
David J. Wood ◽  
J. Dyson ◽  
K. Xiao ◽  
Kenny W. Dalgarno ◽  
P. Genever
Keyword(s):  
Selective Laser Sintering ◽  
Glass Ceramics ◽  
Human Mesenchymal Stem Cells ◽  
Biological Properties ◽  
Laser Sintering ◽  
Porous Scaffolds ◽  
Allogenic Bone ◽  
Static Seeding ◽  
Economic Need

There is a clinical and socio-economic need to produce synthetic alternatives to autologous or allogenic bone grafts. Bioactive glasses and glass-ceramics offer great potential in this area. The aims of this study were to optimise production of apatite-wollastonite (A-W) glassceramic scaffolds produced by selective laser sintering, in terms of their physical and biological properties and to look at how human Mesenchymal Stem Cells (MSCs) responded to these 3-D scaffolds in vitro. An indirect selective laser sintering process successfully produced strong, porous scaffolds. Depending upon particle size(s) and infiltration of the porous structure, flexural strengths between 35 MPa and 100 MPa were obtained. Following static seeding of A-W scaffolds with MSCs, fluoresecent actin and nuclei staining, as observed by confocal microscopy, showed that these scaffolds supported the adherence of human MSC’s at time periods of up to 21 days. As such these seeded scaffolds show great potential for use in bone regenerative medicine.

Selective Laser Sintering of Tissue Engineering Scaffolds Using Poly(L-Lactide) Microspheres

2007 ◽  
Vol 334-335 ◽  
pp. 1225-1228 ◽  
Author(s):  
Wen You Zhou ◽  
S.H. Lee ◽  
Min Wang ◽  
W.L. Cheung
Keyword(s):  
Tissue Engineering ◽  
Porous Scaffold ◽  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Porous Scaffolds ◽  
Tissue Engineering Scaffolds ◽  
Water Emulsion ◽  
Bed Temperature ◽  
Oil In Water Emulsion ◽  
Polyamide Powder

This paper reports a study on the modification of a commercial selective laser sintering (SLS) machine for the fabrication of tissue engineering scaffolds from small quantities of poly(L-lactide) (PLLA) microspheres. A miniature build platform was designed, fabricated and installed in the build cylinder of a Sinterstation 2000 system. Porous scaffolds in the form of rectangular prism, 12.7×12.7×25.4 mm3, with interconnected square and round channels were designed using SolidWorks. For initial trials, DuraFormTM polyamide powder was used to build scaffolds with a designed porosity of ~70%. The actual porosity was found to be ~83%, which indicated that the sintered regions were not fully dense. PLLA microspheres in the size range of 5-30 μm were made using an oil-in-water emulsion solvent evaporation procedure and they were suitable for the SLS process. A porous scaffold was sintered from the PLLA microspheres with a laser power of 15W and a part bed temperature of 60oC. SEM examination showed that the PLLA microspheres were partially melted to form the scaffold. This study has demonstrated that it is feasible to build tissue engineering scaffolds from small amounts of biomaterials using a commercial SLS machine with suitable modifications.

MgO whiskers reinforced poly(vinylidene fluoride) scaffolds

RSC Advances ◽  
2016 ◽  
Vol 6 (110) ◽  
pp. 108196-108202 ◽  
Author(s):  
Wei Huang ◽  
Ping Wu ◽  
Pei Feng ◽  
Youwen Yang ◽  
Wang Guo ◽  
...  
Keyword(s):  
Vinylidene Fluoride ◽  
Selective Laser Sintering ◽  
Biological Properties ◽  
Laser Sintering ◽  
Poly Vinylidene Fluoride

In this study, poly(vinylidene fluoride) (PVDF) scaffolds with MgO whiskers were prepared through selective laser sintering, and their properties were studied in terms of mechanical and biological properties.

Selective laser sintering manufacturing of polycaprolactone bone scaffolds for applications in bone tissue engineering

2015 ◽  
Vol 21 (4) ◽  
pp. 386-392 ◽  
Author(s):  
Alida Mazzoli ◽  
C Ferretti ◽  
A Gigante ◽  
E Salvolini ◽  
M Mattioli-Belmonte
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Design Methodology ◽  
Selective Laser Sintering ◽  
Human Mesenchymal Stem Cells ◽  
Laser Sintering ◽  
Porous Scaffolds ◽  
Content Type ◽  
Skeletal Defects

Purpose – The purpose of this study is to show how selective laser sintering (SLS) manufacturing of bioresorbable scaffolds is used for applications in bone tissue engineering. Design/methodology/approach – Polycaprolactone (PCL) scaffolds were computationally designed and then fabricated via SLS for applications in bone and cartilage repair. Findings – Preliminary biocompatibility data were acquired using human mesenchymal stem cells (hMSCs) assuring a satisfactory scaffold colonization by hMSCs. Originality/value – A promising procedure for producing porous scaffolds for the repair of skeletal defects, in tissue engineering applications, was developed.

Manufacture and Characterisation of Bioceramic Tissue Engineering Scaffolds Produced by Selective Laser Sintering

2007 ◽  
Author(s):  
K. Xiao ◽  
J. A. Dyson ◽  
K. W. Dalgarno ◽  
P. Genever ◽  
D. J. Wood ◽  
...  
Keyword(s):  
Glass Ceramic ◽  
Selective Laser Sintering ◽  
Human Mesenchymal Stem Cells ◽  
Biological Properties ◽  
Laser Sintering ◽  
Process Conditions ◽  
Tissue Engineering Scaffolds ◽  
Process Maps ◽  
Bone Replacement ◽  
Porous Bioceramic

Currently there is no adequate bone replacement available that combines a long implant life with complete integration and appropriate mechanical properties. This paper reports on the use of human mesenchymal stem cells (MSCs) to populate porous bioceramic scaffolds produced by selective laser sintering (SLS) to create bespoke bioactive bone replacement structures. Apatite-wollastonite glass ceramic was chosen for use in this study because of its combination of excellent mechanical and biological properties, and has been processed using an indirect SLS approach. Process maps have been developed to identify process conditions for the SLS stage of manufacture and an optimised furnace cycle for the material has been developed to ensure that the required material phases for bioactivity are present in the manufactured scaffold. Results from tissue culture with the MSC’s on the scaffolds (using confocal and scanning electron microscopy) show that MSCs adhere, spread and retain viability on the surface, and penetrate into the pores of apatite wollastonite (A-W) glass ceramic scaffolds over a 21 day culture period. The MSC’s also show strong indications of osteogenesis, indicating that the MSC’s are differentiating to osteoblasts. These results indicate good biocompatibility and osteo supportive capacity of SLS generated A-W scaffolds and excellent potential in bone replacement applications.

Development of Porous Scaffolds Using Selective Laser Sintering of Polylactic Acid/ Hydroxyapatite for Bone Tissur Engineering

2011 ◽  
Vol 291-294 ◽  
pp. 1399-1404
Author(s):  
Qiang Zhang ◽  
Fu Rong Liu ◽  
Ji Min Chen
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Polylactic Acid ◽  
Selective Laser Sintering ◽  
Laser Sintering ◽  
Porous Scaffolds ◽  
Infrared Spectrophotometry ◽  
Good Potential ◽  
Physical Blending ◽  
Scanning Electron

In this paper the research focused on the viability of using the selective laser sintering (SLS) technique for creating tissue engineer (TE) scaffolds. A biocomposite blend comprising polylactic acid (PLA) and hydroxyapatite (HA) was used in the research to study the feasibility of the blend to develop scaffolds. The biocomposite blends obtained via physical blending were subjected to laser sintering to fabricate test specimens. The test specimens were characterized using scanning electron microscopy (SEM) and the components before sintering and after sintering were analyzed by infrared spectrophotometry (IR). The results obtained ascertained that SLS-fabricated scaffolds have good potential for TE applications

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