Determination of midodrine hydrochloride via Hantzsch condensation reaction: a factorial design based spectrophotometric approach

RSC Advances ◽  
2015 ◽  
Vol 5 (60) ◽  
pp. 48474-48483 ◽  
Author(s):  
Marwa S. Elazazy
Keyword(s):  
Experimental Design ◽  
Factorial Design ◽  
Condensation Reaction ◽  
Current Approach ◽  
Hantzsch Condensation

An experimental design was adopted for determination of MD·HCl. The novelty of the current approach arises from being multivariate compared to traditional univariate techniques.

scholarly journals Correction: Determination of midodrine hydrochloride via Hantzsch condensation reaction: a factorial design based spectrophotometric approach

RSC Advances ◽  
2015 ◽  
Vol 5 (77) ◽  
pp. 62586-62586 ◽  
Author(s):  
Marwa S. Elazazy
Keyword(s):  
Factorial Design ◽  
Condensation Reaction ◽  
Hantzsch Condensation

Correction for ‘Determination of midodrine hydrochloride via Hantzsch condensation reaction: a factorial design based spectrophotometric approach’ by Marwa S. Elazazy et al., RSC Adv., 2015, 5, 48474–48483.

Experimental design and machine learning strategies for parameters screening and optimization of Hantzsch condensation reaction for the assay of sodium alendronate in oral solution

RSC Advances ◽  
2015 ◽  
Vol 5 (9) ◽  
pp. 6385-6394 ◽  
Author(s):  
Mohamed A. Korany ◽  
Marwa A. A. Ragab ◽  
Rasha M. Youssef ◽  
Mostafa A. Afify
Keyword(s):  
Machine Learning ◽  
Experimental Design ◽  
Learning Strategies ◽  
Condensation Reaction ◽  
Oral Solution ◽  
Chemical Derivatization ◽  
Reaction Parameters ◽  
Hantzsch Condensation ◽  
Optimum Reaction

An experimental design was adopted to attain the optimum reaction parameters of chemical derivatization of anhydrous sodium alendronate in an oral solution formulaviaHantzsch condensation reaction.

scholarly journals Interaction of p-synephrine with p-chloranil: experimental design and multiple response optimization

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64967-64976 ◽  
Author(s):  
Marwa S. Elazazy ◽  
K. Ganesh ◽  
V. Sivakumar ◽  
Yasser H. A. Huessein
Keyword(s):  
Experimental Design ◽  
Factorial Design ◽  
Performance Characteristic ◽  
Present Approach ◽  
Multiple Response ◽  
Multiple Responses ◽  
Characteristic P ◽  
Multiple Response Optimization ◽  
Response Optimization

A multivariate factorial design was proposed for determination ofp-synephrine. Novelty of present approach stems from consolidating multiple responses into a unified performance characteristic.

Statistics and parallaxes

1978 ◽  
Vol 48 ◽  
pp. 7-29
Author(s):  
T. E. Lutz
Keyword(s):  
Experimental Design ◽  
Statistical Methods ◽  
Review Paper ◽  
Systematic Errors ◽  
Past Experience ◽  
Random Errors ◽  
Trigonometric Parallaxes ◽  
Systematic And Random Errors

This review paper deals with the use of statistical methods to evaluate systematic and random errors associated with trigonometric parallaxes. First, systematic errors which arise when using trigonometric parallaxes to calibrate luminosity systems are discussed. Next, determination of the external errors of parallax measurement are reviewed. Observatory corrections are discussed. Schilt’s point, that as the causes of these systematic differences between observatories are not known the computed corrections can not be applied appropriately, is emphasized. However, modern parallax work is sufficiently accurate that it is necessary to determine observatory corrections if full use is to be made of the potential precision of the data. To this end, it is suggested that a prior experimental design is required. Past experience has shown that accidental overlap of observing programs will not suffice to determine observatory corrections which are meaningful.

Optimization of PES Nanocomposite Membrane Preparation Using Statistical Analysis and Experimental Design

2019 ◽  
Author(s):  
Yasin Orooji ◽  
Fatemeh Noorisafa ◽  
Nahid Imami ◽  
Amir R. Chaharmahali
Keyword(s):  
Statistical Analysis ◽  
Experimental Design ◽  
Factorial Design ◽  
Fractional Factorial Design ◽  
Fractional Factorial ◽  
Nanocomposite Membrane ◽  
Membrane Preparation ◽  
Membrane Fabrication

<p>Using experimental design and statistical analysis (½ Fractional Factorial Design), this study investigates the effect of different parameters in the membrane fabrication on the performance of nanocomposite PES/TiO<sub>2</sub> membrane. </p>

Respirometry for determination of the influents SS-concentration

1996 ◽  
Vol 33 (1) ◽  
pp. 311-323 ◽  
Author(s):  
A. Witteborg ◽  
A. van der Last ◽  
R. Hamming ◽  
I. Hemmers
Keyword(s):  
Experimental Design ◽  
Activated Sludge ◽  
Substrate Concentration ◽  
Full Scale ◽  
Activated Sludge Process ◽  
Respiration Rates ◽  
On Line ◽  
Large Measurement ◽  
Set Up

A method is presented for determining influent readily biodegradable substrate concentration (SS). The method is based on three different respiration rates, which can be measured with a continuous respiration meter which is operated in a cyclic way. Within the respiration meter nitrification is inhibited through the addition of ATU. Simulations were used to develop the respirometry set-up and decide upon the experimental design. The method was tested as part of a large measurement programme executed at a full-scale plant. The proposed respirometry set-up has been shown to be suitable for a semi-on-line determination of an influent SS which is fully based on the IAWQ #1 vision of the activated sludge process. The YH and the KS play a major role in the principle, and should be measured directly from the process.

Optimum HPLC Conditions for Determination of Dibucaine HCL, Fluocortolone Pivalate and Fluocortolone Caproate by Using Experimental Design

2018 ◽  
Vol 15 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Bürge Aşçı ◽  
Mesut Koç
Keyword(s):  
Experimental Design ◽  
Flow Rate ◽  
Mobile Phase ◽  
High Performance ◽  
Limit Of Detection ◽  
Pharmaceutical Preparations ◽  
Acid Mixture ◽  
Solution Stability ◽  
Uv Detector

Introduction:This paper presents the development and validation of a novel, fast, sensitive and accurate high performance liquid chromatography (HPLC) method for the simultaneous quantitative determination of dibucaine HCl, fluocortolone pivalate and fluocortolone caproate in pharmaceutical preparations.Experiment:Development of the chromatographic method was based on an experimental design approach. A five-level-three-factor central composite design requiring 20 experiments in this optimization study was performed in order to evaluate the effects of three independent variances including mobile phase ratio, flow rate and amount of acid in the mobile phase.Conclusion:The optimum composition for mobile phase was found as a methanol:water:acetic acid mixture at 71.6 : 26.4 : 2 (v/v/v) ratio and optimum separation was acquired by isocratic elution with a flow rate of 1.3 mL/min. The analytes were detected using a UV detector at 240 nm. The developed method was validated in terms of linearity, precision, accuracy, limit of detection/quantitation and solution stability and successfully applied to the determination of dibucaine HCl, fluocortolone pivalate and fluocortolone caproate in pharmaceutical topical formulations such as suppositories and ointments.

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