A novel benzothiazole derivative SKLB826 inhibits human hepatocellular carcinoma growth via inducing G2/M phase arrest and apoptosis

RSC Advances ◽  
2015 ◽  
Vol 5 (52) ◽  
pp. 41341-41351 ◽  
Author(s):  
Qian Lei ◽  
Lidan Zhang ◽  
Yong Xia ◽  
Tinghong Ye ◽  
Fangfang Yang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Human Hepatocellular Carcinoma ◽  
Benzothiazole Derivative ◽  
Common Cancer ◽  
Phase Arrest ◽  
M Phase

Hepatocellular carcinoma is the fifth most common cancer and durable responses in conventional treatments are limited so researchers have been devoted to developing new anti-HCC agents.

6-[(1-naphthylmethyl)sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells

2012 ◽  
Vol 695 (1-3) ◽  
pp. 27-33 ◽  
Author(s):  
Xiao-Guang Yang ◽  
Yong-Li Bao ◽  
Yan-Xin Huang ◽  
Lu-Guo Sun ◽  
Yu-Wei Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepg2 Cells ◽  
Human Hepatocellular Carcinoma ◽  
Phase Arrest ◽  
M Phase

scholarly journals Accumulation of AGO2 Facilitates Tumorigenesis of Human Hepatocellular Carcinoma

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Yang Yang ◽  
Qi Mei
Keyword(s):  
Hepatocellular Carcinoma ◽  
Small Rna ◽  
Human Hepatocellular Carcinoma ◽  
Cell Behaviors ◽  
Phase Arrest ◽  
G1 Phase Arrest ◽  
Different Types ◽  
Cell Cycle Inhibition ◽  
Xenograft Mice

AGO2 (Argonaute RISC Catalytic Component 2) plays an important role in small RNA-guided gene silencing processes. It has been implied in tumorigenesis of different types of tumors. In this study, we found that AGO2 expression was remarkably increased in human hepatocellular carcinoma (HCC) tissues when compared with adjacent noncancerous tissues. High expression of AGO2 was associated with poor prognosis in HCC patients. The CRISPR/Cas9-mediated knockout of AGO2 in SMMC-7721 cells inhibited cell proliferation and induced significant G1 phase arrest of cell cycle. Inhibition of cell migration was also observed in SMMC-7721 AGO2-/- cells. In vivo experiments showed that tumors grew slower in nude mice transplanted with AGO2-/- cells than in SMMC-7721 cell-derived xenograft mice. Microarray analysis and western blot analysis revealed that AGO2 depletion decreased expression of Survivin, Vimentin, and Snail. Overexpression of AGO2 in SMMC-7721 and Huh-7 cells could reverse the knockout-induced inhibition effects on either cell behaviors or expression of Survivin, Vimentin, and Snail Therefore, our data demonstrated that AGO2 might facilitate HCC tumorigenesis and metastasis through modulating expression of Survivin, Vimentin, and Snail.

scholarly journals Human Hepatocellular Carcinoma (HCC)

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3739
Author(s):  
Luigi Buonaguro
Keyword(s):  
Hepatocellular Carcinoma ◽  
Human Hepatocellular Carcinoma ◽  
Common Cancer

Hepatocellular carcinoma (HCC) is the fifth most common cancer and accounts for 8 [...]

Corilagin inhibits hepatocellular carcinoma cell proliferation by inducing G2/M phase arrest

2013 ◽  
Vol 37 (10) ◽  
pp. 1046-1054 ◽  
Author(s):  
Yanlin Ming ◽  
Zhizhong Zheng ◽  
Lianghua Chen ◽  
Guohua Zheng ◽  
Shaosong Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Carcinoma Cell ◽  
Phase Arrest ◽  
M Phase ◽  
Hepatocellular Carcinoma Cell
Sign in / Sign up

Export Citation Format

Share Document