Apigenin mediated gold nanoparticle synthesis and their anti-cancer effect on human epidermoid carcinoma (A431) cells

RSC Advances ◽  
2015 ◽  
Vol 5 (63) ◽  
pp. 51055-51066 ◽  
Author(s):  
Indra Rajendran ◽  
Harini Dhandapani ◽  
Rajaram Anantanarayanan ◽  
Rama Rajaram
Keyword(s):  
Gold Nanoparticle ◽  
Nanoparticle Synthesis ◽  
Epidermoid Carcinoma ◽  
Hacat Cells ◽  
A431 Cells ◽  
Anti Cancer ◽  
Gold Nanoparticle Synthesis ◽  
Cancer Activity ◽  
Human Epidermoid Carcinoma

Apigenin reduces Au3+to Au0to form ap-AuNPs at RT. ap-AuNPs are biocompatible towards HaCat cells. They show anti-cancer activity towards A431 cells by inducing apoptosis.

scholarly journals Multifloroside Suppressing Proliferation and Colony Formation, Inducing S Cell Cycle Arrest, ROS Production, and Increasing MMP in Human Epidermoid Carcinoma Cell Lines A431

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 7 ◽  
Author(s):  
Xin Zhang ◽  
Yamei Li ◽  
Zhengping Feng ◽  
Yaling Zhang ◽  
Ye Gong ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Lines ◽  
Colony Formation ◽  
Carcinoma Cell ◽  
A431 Cells ◽  
Cycle Arrest ◽  
Carcinoma Cell Lines ◽  
Anti Cancer ◽  
Cancer Activity ◽  
Human Epidermoid Carcinoma

Multifloroside (4), together with 10-hydroxyoleoside 11-methyl ester (1), 10-hydroxyoleoside dimethyl ester (2), and 10-hydroxyligustroside (3), are all secoiridoids, which are naturally occurring compounds that possess a wide range of biological and pharmacological activities. However, the anti-cancer activity of 1–4 has not been evaluated yet. The objective of this work was to study the anti-cancer activities of 1–4 in the human epidermoid carcinoma cell lines A431 and the human non-small cell lung cancer (NSCLC) cell lines A549. The results indicate that 1–4 differ in potency in their ability to inhibit the proliferation of human A431 and A549 cells, and multifloroside (4) display the highest inhibitory activity against A431 cells. The structure-activity relationships suggest that the o-hydroxy-p-hydroxy-phenylethyl group may contribute to the anti-cancer activity against A431 cells. Multifloroside treatment can also inhibit cell colony formation, arrest the cell cycle in the S-phase, increase the levels of reactive-oxygen-species (ROS), and mitochondrial membrane potential (MMP), but it did not significantly induce cell apoptosis at low concentrations. The findings indicated that multifloroside (4) has the tendency to show selective anti-cancer effects in A431 cells, along with suppressing the colony formation, inducing S cell cycle arrest, ROS production, and increasing MMP.

Effect of voltage polarity and supply frequency on properties of plasma contacting liquid electrode and gold nanoparticle synthesis

2021 ◽  
Author(s):  
Phuoc Van Thai ◽  
Nobuo Saito ◽  
Tsubasa Nakamura ◽  
Kazumasa Takahashi ◽  
Toru Sasaki ◽  
...  
Keyword(s):  
Gold Nanoparticle ◽  
Charged Particles ◽  
Nanoparticle Synthesis ◽  
Chemical Properties ◽  
Bulk Liquid ◽  
Solvated Electrons ◽  
Plasma Properties ◽  
Voltage Polarity ◽  
Specific Species ◽  
Gold Nanoparticle Synthesis

Abstract Plasma contacting with liquid provides many charged particles and reactive species into the liquid. The difficulty in controlling or selecting each specific species has significantly limited its applications in industry. Here, we present a study on using voltage polarity to regulate the type of charged particles absorbing from plasma into liquid. Detailed understanding of the processes at the plasma-liquid interface, electrolysis due to switching in voltage polarity was investigated via a visual pH observation, measuring the concentration of H2O2 and solvated electrons. The results indicated that changing in voltage polarity strongly affects the plasma properties, chemical properties, and electrolysis process in liquid, and further in the types of reducing species for gold nanoparticle synthesis. The results also showed using a suitable frequency could improve the efficiency of absorption of H2O2from plasma into the bulk liquid and the yield in the production of gold nanoparticles. The results provide a way to select desired species from plasma into the liquid for a distinct purpose and accompanying other properties in the system of plasma contacting with liquid.

scholarly journals Characterization of Conventional One-Step Sodium Thiosulfate Facilitated Gold Nanoparticle Synthesis

2015 ◽  
Vol 10 (1) ◽  
Author(s):  
Scott-Eugene Saverot ◽  
Laura M Reese ◽  
Daniela Cimini ◽  
Peter J Vikesland ◽  
Lissett Ramirez Bickford
Keyword(s):  
Gold Nanoparticle ◽  
Sodium Thiosulfate ◽  
Nanoparticle Synthesis ◽  
One Step ◽  
Gold Nanoparticle Synthesis

scholarly journals Mitochondrial Pathway of α-Tocopheryl Succinate-Induced Apoptosis in Human Epidermoid Carcinoma A431 Cells

Acta Naturae ◽  
2012 ◽  
Vol 4 (3) ◽  
pp. 88-94 ◽  
Author(s):  
M. A. Savitskaya ◽  
M. S. Vildanova ◽  
O. P. Kisurina-Evgenieva ◽  
E. A. Smirnova ◽  
G. E. Onischenko
Keyword(s):  
Cell Death ◽  
Vitamin E ◽  
Apoptotic Cell ◽  
Mitochondrial Pathway ◽  
Epidermoid Carcinoma ◽  
A431 Cells ◽  
Human Carcinoma ◽  
Tocopheryl Succinate ◽  
Induced Apoptosis ◽  
Human Epidermoid Carcinoma

Vitamin E derivatives are known to act as agents exhibiting cytotoxity against tumor cells. The effect of vitamin E succinate on human epidermoid carcinoma cell line A431 was investigated in this study using live imaging, immunocytochemistry, and transmission electron microscopy. -Tocopheryl succinate-induced apoptotic cell death in A431 cells was shown to be both dose- and time-dependent. The hyperproduction of reactive oxygen species, changes in size, shape and ultrastructural characteristics of mitochondria followed by the release of cytochrome c from mitochondria to cytosol were observed. These results suggest that -tocopheryl succinate induces apoptosis that occurs via the mitochondrial pathway. Mitochondria are shown to be crucial targets in -tocopheryl succinate-induced caspase-dependent cell death in human carcinoma A431 cells.

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