Coupling a novel spiro-rhodamine B lactam derivative to Fe3O4 nanoparticles for visual detection of free copper ions with high sensitivity and specificity

RSC Advances ◽  
2015 ◽  
Vol 5 (57) ◽  
pp. 45847-45852 ◽  
Author(s):  
Hongyan Zhang ◽  
Xiaoxue Zeng ◽  
Danlong Chen ◽  
Ying Guo ◽  
Wenjing Jiang ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Rhodamine B ◽  
Fe3o4 Nanoparticles ◽  
Visual Detection ◽  
Copper Ions ◽  
Tap Water ◽  
High Sensitivity ◽  
Visual Sensor ◽  
Naked Eye

A novel spiro-rhodamine B lactam derivative, which can be coupled to Fe3O4 NPs and act as a Cu2+-selective visual sensor is reported. It can be used to directly detect as little as 50 nM of Cu2+ in river or tap water by only naked-eye observation.

A novel phosphatidylserine-functionalized AuNP for the visual detection of free copper ions with high sensitivity and specificity

2014 ◽  
Vol 2 (44) ◽  
pp. 7765-7770 ◽  
Author(s):  
WeiJuan Yang ◽  
Ye He ◽  
LiangJun Xu ◽  
Danlong Chen ◽  
Mengxue Li ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Visual Detection ◽  
Copper Ions ◽  
High Sensitivity

A target-induced and equipment-free biosensor for amplified visual detection of pesticide acetamiprid with high sensitivity and selectivity

2019 ◽  
Vol 11 (9) ◽  
pp. 1168-1173 ◽  
Author(s):  
Lingwen Zeng ◽  
Danhua Zhou ◽  
Jinghua Wu ◽  
Chengshuai Liu ◽  
Junhua Chen
Keyword(s):  
Visual Detection ◽  
High Sensitivity ◽  
Naked Eye ◽  
G Quadruplex ◽  
Sensitivity And Selectivity

An equipment-free and naked-eye biosensor was developed for amplified detection of pesticide acetamiprid using G-quadruplex as the signal reporter.

A carbon-dot-based dual-emission probe for ultrasensitive visual detection of copper ions

2018 ◽  
Vol 42 (24) ◽  
pp. 19771-19778 ◽  
Author(s):  
Yunsuo Kuang ◽  
Linfeng Chen ◽  
Jiahui Lu ◽  
Xike Tian ◽  
Chao Yang ◽  
...  
Keyword(s):  
Rhodamine B ◽  
Carbon Dots ◽  
Visual Detection ◽  
Copper Ions ◽  
Fluorescent Sensor ◽  
Dual Emission ◽  
Carbon Dot

In this work, we successfully developed an ultrasensitive dual-emission fluorescent sensor (CRB) for instant visual determination of Cu2+ by modifying a Cu-sensitive rhodamine B derivative (RB) onto photostable carboxyl modified carbon dots (CDs).

Fluorogenic bidirectional displacement probe-based real-time isothermal DNA amplification and specific visual detection of products

2016 ◽  
Vol 52 (76) ◽  
pp. 11438-11441 ◽  
Author(s):  
Xiong Ding ◽  
Guoping Wang ◽  
Jingjing Sun ◽  
Tao Zhang ◽  
Ying Mu
Keyword(s):  
Real Time ◽  
Sensitivity And Specificity ◽  
Visual Detection ◽  
Dna Amplification ◽  
High Sensitivity

We report an easy-to-design probe as both the primer and the indicator to mediate isothermal DNA amplification with high sensitivity and specificity.

Natural betanin dye extracted from bougainvillea flowers for the naked-eye detection of copper ions in water samples

2016 ◽  
Vol 8 (25) ◽  
pp. 4977-4982 ◽  
Author(s):  
Mohamed Khairy ◽  
Mohamed Ismael ◽  
Rafat M. El-Khatib ◽  
Mostafa Abdelnaeem ◽  
Mariam Khalaf
Keyword(s):  
Optical Sensor ◽  
Water Samples ◽  
Copper Ions ◽  
Tap Water ◽  
Experimental Results ◽  
Selective Detection ◽  
Eye Detection ◽  
Color Changes ◽  
Naked Eye ◽  
Naked Eye Detection

A betanin-based colorimetric probe was simply extracted from bougainvillea flowers for the selective detection of Cu2+ ions. The experimental results showed that the betanin pigment could be employed as an optical sensor for Cu2+ with significant color changes in tap water samples.

Detector-C: A Blood-based IVD with High Sensitivity and Specificity for Early Detection and Screening of Colorectal Cancer

2010 ◽  
Vol 48 (08) ◽  
Author(s):  
A Rosenthal ◽  
H Köppen ◽  
R Musikowski ◽  
R Schwanitz ◽  
J Behrendt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Detection ◽  
Sensitivity And Specificity ◽  
High Sensitivity

Trends in Diagnosis for Active Tuberculosis Using Nanomaterials

2019 ◽  
Vol 26 (11) ◽  
pp. 1946-1959 ◽  
Author(s):  
Le Minh Tu Phan ◽  
Lemma Teshome Tufa ◽  
Hwa-Jung Kim ◽  
Jaebeom Lee ◽  
Tae Jung Park
Keyword(s):  
Sensitivity And Specificity ◽  
High Efficiency ◽  
Point Of Care ◽  
High Sensitivity ◽  
Signs And Symptoms ◽  
Diagnostic Methods ◽  
Advantages And Disadvantages ◽  
Treatment And Prevention ◽  
Clinical Tools ◽  
Diagnostic Applications

Background:Tuberculosis (TB), one of the leading causes of death worldwide, is difficult to diagnose based only on signs and symptoms. Methods for TB detection are continuously being researched to design novel effective clinical tools for the diagnosis of TB.Objective:This article reviews the methods to diagnose TB at the latent and active stages and to recognize prospective TB diagnostic methods based on nanomaterials.Methods:The current methods for TB diagnosis were reviewed by evaluating their advantages and disadvantages. Furthermore, the trends in TB detection using nanomaterials were discussed regarding their performance capacity for clinical diagnostic applications.Results:Current methods such as microscopy, culture, and tuberculin skin test are still being employed to diagnose TB, however, a highly sensitive point of care tool without false results is still needed. The utilization of nanomaterials to detect the specific TB biomarkers with high sensitivity and specificity can provide a possible strategy to rapidly diagnose TB. Although it is challenging for nanodiagnostic platforms to be assessed in clinical trials, active TB diagnosis using nanomaterials is highly expected to achieve clinical significance for regular application. In addition, aspects and future directions in developing the high-efficiency tools to diagnose active TB using advanced nanomaterials are expounded.Conclusion:This review suggests that nanomaterials have high potential as rapid, costeffective tools to enhance the diagnostic sensitivity and specificity for the accurate diagnosis, treatment, and prevention of TB. Hence, portable nanobiosensors can be alternative effective tests to be exploited globally after clinical trial execution.

Value of Coronary Calcium Scoring in Symptomatic and Asymptomatic Coronary Artery Disease Patients

2020 ◽  
Vol 16 ◽  
Author(s):  
Hala T. Salem ◽  
Eman A.S. Sabek
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Sensitivity And Specificity ◽  
High Sensitivity ◽  
Coronary Calcium ◽  
Risk Estimate ◽  
Calcium Scoring ◽  
Coronary Calcium Scoring ◽  
Framingham Risk ◽  
Artery Disease

Aim and Objective: To estimate the relationship between Coronary Calcium Scoring (CCS)and presence of different degrees of obstructive coronary artery disease (CAD) to avoid unnecessary examinations and hence unnecessary radiation exposure and contrast injection. Background: Coronary Calcium Scoring (CCS) is a test uses x-ray equipment to produce pictures of the coronary arteries to determine the degree of its narrowing by the build-up of calcified plaques. Despite the lack of definitive data linking ionizing radiation with cancer, the American Heart Association supports widely that practitioners of Computed tomography Coronary Angiography (CTCA) should keep “patient radiation doses as low as reasonably achievable but consistent with obtaining the desired medical information”. Methods: Data obtained from 275 CTCA examinations were reviewed. Radiation effective doses were estimated for both CCS and CTCA, measures to keep it as low as possible were presented, CCS and Framingham risk estimate were compared to the final results of CTCA to detect sensitivity and specificity of each one in detecting obstructive lesions. Results: CCS is a strong discriminator for obstructive CAD and can with high sensitivity and specificity and correlates well with the degree of obstruction even more than Framingham risk estimate which has high sensitivity and low specificity. Conclusion: CCS helps reducing the effective radiation dose if properly evaluated to skip unnecessary CTCA if obstructive lesions was unlikely, and as a test does not use contrast material, harmful effect on the kidney will be avoided as most of coronary atherosclerotic patients have renal problems.

scholarly journals Blood-Based Detection of Colorectal Cancer Using Cancer-Specific DNA Methylation Markers

Diagnostics ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 51
Author(s):  
Nam-Yun Cho ◽  
Ji-Won Park ◽  
Xianyu Wen ◽  
Yun-Joo Shin ◽  
Jun-Kyu Kang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Dna Methylation ◽  
Sensitivity And Specificity ◽  
Stage Iv ◽  
High Sensitivity ◽  
Liquid Biopsies ◽  
Blood Leukocytes ◽  
Marker Panel ◽  
A Genome ◽  
Methylight Assay

Cancer tissues have characteristic DNA methylation profiles compared with their corresponding normal tissues that can be utilized for cancer diagnosis with liquid biopsy. Using a genome-scale DNA methylation approach, we sought to identify a panel of DNA methylation markers specific for cell-free DNA (cfDNA) from patients with colorectal cancer (CRC). By comparing DNA methylomes between CRC and normal mucosal tissues or blood leukocytes, we identified eight cancer-specific methylated loci (ADGRB1, ANKRD13, FAM123A, GLI3, PCDHG, PPP1R16B, SLIT3, and TMEM90B) and developed a five-marker panel (FAM123A, GLI3, PPP1R16B, SLIT3, and TMEM90B) that detected CRC in liquid biopsies with a high sensitivity and specificity with a droplet digital MethyLight assay. In a set of cfDNA samples from CRC patients (n = 117) and healthy volunteers (n = 60), a panel of five markers on the platform of the droplet digital MethyLight assay detected stages I–III and stage IV CRCs with sensitivities of 45.9% and 95.7%, respectively, and a specificity of 95.0%. The number of detected markers was correlated with the cancer stage, perineural invasion, lymphatic emboli, and venous invasion. Our five-marker panel with the droplet digital MethyLight assay showed a high sensitivity and specificity for the detection of CRC with cfDNA samples from patients with metastatic CRC.

scholarly journals Ultrarapid On-Site Detection of SARS-CoV-2 Infection Using Simple ATR-FTIR Spectroscopy and an Analysis Algorithm: High Sensitivity and Specificity

2021 ◽  
Vol 93 (5) ◽  
pp. 2950-2958
Author(s):  
Valério G. Barauna ◽  
Maneesh N. Singh ◽  
Leonardo Leal Barbosa ◽  
Wena Dantas Marcarini ◽  
Paula Frizera Vassallo ◽  
...  
Keyword(s):  
Ftir Spectroscopy ◽  
Sensitivity And Specificity ◽  
High Sensitivity ◽  
Analysis Algorithm
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