Aqueous radical addition-coupling polymerization using a nitroso benzene/cyclodextrin complex for the synthesis of a hydrophilic periodic polymer

RSC Advances ◽  
2015 ◽  
Vol 5 (57) ◽  
pp. 46007-46010 ◽  
Author(s):  
Fangqi Tao ◽  
Qi Wang
Keyword(s):  
Inclusion Complex ◽  
Radical Addition ◽  
Water Soluble ◽  
Cyclodextrin Complex ◽  
Coupling Polymerization

Hydrophilic periodic polymer possessing [ABxAC]n repeating sequence was synthesized by aqueous radical addition-coupling polymerization using water-soluble inclusion complex of nitrosobenzene and Me2-β-cyclodextrin.

Aqueous radical addition-coupling polymerization for the synthesis of hydrophilic periodic polymer

RSC Advances ◽  
2014 ◽  
Vol 4 (95) ◽  
pp. 53253-53256 ◽  
Author(s):  
Fangqi Tao ◽  
Junjie Li ◽  
Qi Wang
Keyword(s):  
Ethylene Oxide ◽  
Radical Addition ◽  
Water Soluble ◽  
Hydrophilic Polymer ◽  
Nitroso Compound ◽  
Coupling Polymerization

A hydrophilic polymer possessing a [ABxAC]n (A = ester, B = ethylene oxide, C = N–O) repeating sequence was synthesized by an aqueous radical addition-coupling polymerization using water-soluble dibromide and a nitroso compound in the presence of a CuBr/ligand.

scholarly journals Development of Orodispersible Tablets of Candesartan Cilexetil-β-cyclodextrin Complex

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Maddukuri Sravya ◽  
Rajamanickam Deveswaran ◽  
Srinivasan Bharath ◽  
Basappa Veerbadraiah Basavaraj ◽  
Varadharajan Madhavan
Keyword(s):  
Inclusion Complex ◽  
Inclusion Complexes ◽  
Candesartan Cilexetil ◽  
Water Soluble ◽  
Molar Ratio ◽  
Spectral Studies ◽  
Dissolution Profile ◽  
Cyclodextrin Complex ◽  
Disintegration Time ◽  
Orodispersible Tablets

The aim of this study was to investigate the use of inclusion complexation technique employing β-cyclodextrin in improving the dissolution profile of candesartan cilexetil, a BCS class-II drug, and to formulate the inclusion complex into orodispersible tablets. The inclusion complexes were formed by physical mixing, kneading, coevaporation, and lyophilisation methods. Inclusion complexes were characterized by FTIR, DSC, XRD, NMR, and mass spectral studies. Inclusion complexes prepared using kneading, and lyophilisation techniques in the molar ratio 1 : 5 with β-cyclodextrin were used for formulating orodispersible tablets by direct compression with different superdisintegrants like croscarmellose sodium, crospovidone, sodium starch glycolate, and low substituted hydroxypropyl cellulose in varying concentrations. The directly compressible powder was evaluated for precompression parameters, and the prepared orodispersible tablets were evaluated for postcompression parameters. Drug-excipient compatibility studies showed no interaction, and characterization proved the formation of inclusion complex. In vitro disintegration time was found to be within 3 minutes, and all the formulations showed complete drug release of 100% within 20 minutes. The optimized formulation was found to be stable after 6 months and showed no significant change in drug content. This work proved β-cyclodextrins to be effective solubilizing agent in improving the solubility of poorly water soluble drugs.

Solubility Enhancement of the Poorly Water-Soluble Antiulcer Drug Famotidine by Inclusion Complexation

2013 ◽  
Vol 6 (1) ◽  
pp. 1983-1989 ◽  
Author(s):  
Shabnam Ain ◽  
V Gupta ◽  
Babita K ◽  
Q Ain ◽  
J Dahiya
Keyword(s):  
Inclusion Complex ◽  
Dissolution Rate ◽  
Phosphate Buffer ◽  
Physical Mixture ◽  
Water Soluble ◽  
Molar Ratio ◽  
Phase Solubility ◽  
Distilled Water ◽  
Physicochemical Interaction ◽  
Mixture Phase

Aqueous solubility is a critical factor for optimum drug delivery. In the present study, we investigated the potential of drug-cyclodextrin complexation as an approach for improving the solubility and bioavailability of famotidine, an H2-receptor antagonist and acid reducing drug which has poor solubility and bioavailability. Solubility improvement of drug by β-cyclodextrin was done by simple complexation approach using physical, kneading and co-precipitation methods and compared with physical mixture. Phase solubility profile indicated that the solubility of famotidine was significantly increased in presence of β-cyclodextrin and shows a linear graph with β-cyclodextrin indicating formation of inclusion complexes in a 1:1 molar ratio. β-Cyclodextrin-famotidine mixture have maximum stability constant 1477.6 M-1. The inclusion complex ratio 1:1 of kneading mixture was selected based on drug release profile and compared with physical mixture. Further characterization was done by  using Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) to identify the physicochemical interaction between drug and carrier and its effect on dissolution. Dissolution rate studies for selected inclusion complex was performed in 0.1 N HCl (pH 1.2), phosphate buffer (pH 7.5) and distilled water (pH 6.8) and compared these to pure drug profile which was found to be 2.34 fold increase in distilled water, 1.83 fold in HCl and 2.01 fold in phosphate buffer (pH 7.5). These results suggest that the kneaded complex of famotidine with β-cyclodextrin as hydrophilic complexation agent can substantially enhance the solubility and dissolution rate. Such complex has promising potential to improve the bioavailability of famotidine.  

BEHAVIOURAL STUDY OF CYCLODEXTRIN INCLUSION COMPLEX ON ENHANCEMENT OF SOLUBILITY OF ACECLOFENAC

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (11) ◽  
pp. 19-23
Author(s):  
J Shaikh ◽  
◽  
S. V. Deshmane ◽  
R. N Purohit ◽  
K. R. Biyani
Keyword(s):  
Inclusion Complex ◽  
Solid Dispersion ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Phase Solubility ◽  
Solubility Study ◽  
Cyclodextrin Inclusion ◽  
Poorly Water Soluble ◽  
Cyclodextrin Inclusion Complex

The main objective of the present study was to enhance the solubility and dissolution rate of poorly water soluble aceclofenac using its solid dispersion with β-cyclodextrin. FTIR and DSC study was carried out to find out any incompatibility. The phase solubility of drug was carried out in 1, 2, 5, and 10% of β-cyclodextrin in distilled water. Kneading method and solvent evaporation method was use to prepared solid dispersion of aceclofenac and β-cyclodextrin. Different evaluation tests like solubility study in different solvents, PXRD and in vitro dissolution study of aceclofenac- β-cyclodextrin inclusion complex were carried out. The overall finding indicated that β-cyclodextrin is a desirable water soluble carrier, that helps in increasing solubility of drug. Due to its structural feature, β-cyclodextrin forms a good inclusion complex that decreases contact angle of drug with water molecules by increasing wetting properties. Hence, it can be concluded that, β-cyclodextrin is better water soluble carrier molecule in terms of its compatibility and increasing solubility behavior of poorly water soluble drug aceclofenac.

Water-soluble loratadine inclusion complex: Analytical control of the preparation by microwave irradiation

2008 ◽  
Vol 48 (3) ◽  
pp. 1020-1023 ◽  
Author(s):  
Á. Nacsa ◽  
R. Ambrus ◽  
O. Berkesi ◽  
P. Szabó-Révész ◽  
Z. Aigner
Keyword(s):  
Microwave Irradiation ◽  
Inclusion Complex ◽  
Water Soluble ◽  
Analytical Control

Water-soluble β-cyclodextrin grafted with chitosan and its inclusion complex as a mucoadhesive eugenol carrier

2012 ◽  
Vol 89 (2) ◽  
pp. 623-631 ◽  
Author(s):  
Warayuth Sajomsang ◽  
Onanong Nuchuchua ◽  
Pattarapond Gonil ◽  
Somsak Saesoo ◽  
Issara Sramala ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Water Soluble
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