Identification of nitric oxide-releasing derivatives of oleanolic acid as potential anti-colon cancer agents

RSC Advances ◽  
2015 ◽  
Vol 5 (25) ◽  
pp. 19445-19454 ◽  
Author(s):  
Junjie Fu ◽  
Yu Zou ◽  
Zhangjian Huang ◽  
Chang Yan ◽  
Qimeng Zhou ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Colon Cancer ◽  
Signaling Pathways ◽  
Oleanolic Acid ◽  
Nitric Oxide Releasing ◽  
Derivatives Of ◽  
Cancer Activity

NO-releasing hybrid 6 regulates colon cancer-related signaling pathways, exhibiting potent anti-colon cancer activity in vitro and in vivo.

Nitric Oxide-Donating Derivatives of Chrysin Stimulate Angiogenesis and Upregulating VEGF Production

2011 ◽  
Vol 340 ◽  
pp. 363-368 ◽  
Author(s):  
Xiao Qing Zou ◽  
Yong Lan Ding ◽  
Sheng Ming Peng ◽  
Chang Ping Hu ◽  
Han Wu Deng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Therapeutic Option ◽  
Therapeutic Angiogenesis ◽  
Vegf Mrna ◽  
No Donor ◽  
Endothelial Migration ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

Angiogenesis, the development of new capillaries from pre-existing vessels, requires the coordinate activation of endothelial cells, which migrate and proliferate to form functional vessels. Endothelial dysfunction and decreased nitric oxide bioavailability may underscore the impairment of angiogenesis. As such, the delivery of exogenous NO is an attractive therapeutic option that has been used to therapeutic angiogenesis. In this paper, a novel group of hybrid nitric oxide-releasing chrysin derivatives was synthesized. The results indicated that all these chrysin derivatives exhibited promotion of endothelial migration and tubulogenesis in vitro as well as stimulation angiogenesis in vivo.Furthermore, all compounds released NO upon incubation with phosphate buffer at pH 7.4 and enhanced VEGF secretion and VEGF mRNA expression of endothelial cells. These hybrid ester NO donor prodrugs offer a potential drug design concept for the development of therapeutic or preventive agents for angiogenesis deficiency due to ischemic diseases.

scholarly journals 536 In vitro and in vivo efficacy of nitric oxide-releasing antiviral therapeutic agents

2016 ◽  
Vol 136 (5) ◽  
pp. S95
Author(s):  
K.A. McHale ◽  
K. Balogh ◽  
H. Wang ◽  
S. Hollenbach ◽  
N. Christensen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Therapeutic Agents ◽  
In Vivo Efficacy ◽  
Nitric Oxide Releasing

scholarly journals Design, Synthesis, and Antihepatocellular Carcinoma Activity of Nitric Oxide Releasing Derivatives of Oleanolic Acid

2008 ◽  
Vol 51 (15) ◽  
pp. 4834-4838 ◽  
Author(s):  
Li Chen ◽  
Yihua Zhang ◽  
Xiangwen Kong ◽  
Edward Lan ◽  
Zhangjian Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Oleanolic Acid ◽  
Design Synthesis ◽  
Nitric Oxide Releasing ◽  
Derivatives Of

IN VIVO AND IN VITRO EVALUATION OF ANTI-CANCER ACTIVITY OF NEWLY SYNTHESIZED COBALT COMPLEX OF COUMARIN SCHIFF BASES

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (04) ◽  
pp. 61-69
Author(s):  
A. Rayaji ◽  
A. H. M. Viswanatha Swamy ◽  
Keyword(s):  
Nitric Oxide ◽  
Hepg2 Cell ◽  
Cobalt Complex ◽  
Reducing Ability ◽  
Anti Cancer ◽  
Anti Oxidant ◽  
Hepg2 Cell Lines ◽  
Cancer Activity

Hepatocarcinogenesis is a multistep process involving different genetic alterations that ultimately lead to malignant transformation of the hepatocytes. Modern treatment of cancer includes chemotherapy, hormone therapy, radiotherapy and surgery but they are associated with several adverse effects such as alopecia, fatigue and general weakening of the body’s immune system due to bone marrow suppression. However, there is a continual need to look out for newer drugs to overcome the menace of cancer. In view of this we synthesized the new Coumarin-Cobalt complex derivatives. Structures of all the newly synthesized metal complexes are supported by Spectral data such as IR, NMR, and mass spectrometry. Coumarin-Cobalt complex of vanillin exhibited significant anti-cancer activity by in vivo anticancer activity (BrdU estimation). Immunohistochemical analysis has been done by BrdU and the synthesized compounds were screened for anti-oxidant activity and in vitro HepG2 cell lines. The IC50 values of the HepG2 cell lines as compared with that of standard Cisplatin and compounds IIIb, IIId, IIIe, IIIh and IIIj showed appreciable activity at a concentration less than 10 μG. Coumarin-Cobalt complex of vanillin exhibited significant anti-cancer activity. Anti-oxidant activity performed by Nitric oxide reducing ability, Superoxide dismutase and reducing activity:Compounds IIIc, IIIe and IIIg showed appreciable activity at 400μg/mL and 800 μg/mL screened by nitric oxide reducing ability, superoxide anion was effectively scavenged by compound IIIg at 400μg/mL and 800 μg/mL and reducing power of compounds IIIc and IIIj is comparable with standard ascorbic acid at concentrations 400μg/mL and 800 μg/mL.

Bioassay-guided isolation of glycoprotein SPG-56 from sweet potato Zhongshu-1 and its anti-colon cancer activity in vitro and in vivo

2017 ◽  
Vol 35 ◽  
pp. 315-324 ◽  
Author(s):  
Meimei Wang ◽  
Hang Ma ◽  
Cheng Tian ◽  
Shanshan Liu ◽  
Xiaoli Ye ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Sweet Potato ◽  
Cancer Activity

scholarly journals Nitric Oxide-Releasing Aspirin Suppresses NF-κB Signaling in Estrogen Receptor Negative Breast Cancer Cells in Vitro and in Vivo

Molecules ◽  
2015 ◽  
Vol 20 (7) ◽  
pp. 12481-12499 ◽  
Author(s):  
Niharika Nath ◽  
Mitali Chattopadhyay ◽  
Deborah Rodes ◽  
Anna Nazarenko ◽  
Ravinder Kodela ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Nitric Oxide ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Nitric Oxide Releasing ◽  
Estrogen Receptor Negative
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