Facile synthesis of drug-conjugated PHPMA core-crosslinked star polymers

2015 ◽  
Vol 6 (23) ◽  
pp. 4258-4263 ◽  
Author(s):  
Bryan S. Tucker ◽  
Stephen G. Getchell ◽  
Megan R. Hill ◽  
Brent S. Sumerlin
Keyword(s):  
Drug Delivery ◽  
Star Polymers ◽  
Potential Drug ◽  
Facile Synthesis ◽  
Hydroxypropyl Methacrylamide ◽  
Drug Delivery Applications

Poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA), a biocompatible and non-immunogenic polymer, was used to form core-crosslinked star polymers for potential drug delivery applications.

Synthesis and Characterization of Dendrimer-Based Polysarcosine Star Polymers: Well-Defined, Versatile Platforms Designed for Drug-Delivery Applications

2020 ◽  
Vol 21 (8) ◽  
pp. 3332-3341 ◽  
Author(s):  
Richard M. England ◽  
Jennifer I. Moss ◽  
Anders Gunnarsson ◽  
Jeremy S. Parker ◽  
Marianne B. Ashford
Keyword(s):  
Drug Delivery ◽  
Star Polymers ◽  
Synthesis And Characterization ◽  
Drug Delivery Applications

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

Synthesis and Characterization of pH-Sensitive Biodegradable Polyurethane for Potential Drug Delivery Applications

2011 ◽  
Vol 44 (4) ◽  
pp. 857-864 ◽  
Author(s):  
Lijuan Zhou ◽  
Lunquan Yu ◽  
Mingming Ding ◽  
Jiehua Li ◽  
Hong Tan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ph Sensitive ◽  
Synthesis And Characterization ◽  
Potential Drug ◽  
Biodegradable Polyurethane ◽  
Drug Delivery Applications

Design of interpenetrating chitosan and poly(ethylene glycol) sponges for potential drug delivery applications

2017 ◽  
Vol 170 ◽  
pp. 166-175 ◽  
Author(s):  
Lisa Racine ◽  
Guillaume Costa ◽  
Eric Bayma-Pecit ◽  
Isabelle Texier ◽  
Rachel Auzély-Velty
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene

Carrageenan: A Wonder Polymer from Marine Algae for Potential Drug Delivery Applications

2019 ◽  
Vol 25 (11) ◽  
pp. 1172-1186 ◽  
Author(s):  
Dilshad Qureshi ◽  
Suraj Kumar Nayak ◽  
Samarendra Maji ◽  
Doman Kim ◽  
Indranil Banerjee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biological Activities ◽  
Medical Science ◽  
Drug Carriers ◽  
Sulfated Polysaccharides ◽  
Potential Drug ◽  
Natural Polymers ◽  
Structural Variations ◽  
Varied Range ◽  
Drug Delivery Applications

Background: With the advancement in the field of medical science, the idea of sustained release of the therapeutic agents in the patient’s body has remained a major thrust for developing advanced drug delivery systems (DDSs). The critical requirement for fabricating these DDSs is to facilitate the delivery of their cargos in a spatio-temporal and pharmacokinetically-controlled manner. Albeit the synthetic polymer-based DDSs normally address the above-mentioned conditions, their potential cytotoxicity and high cost have ultimately constrained their success. Consequently, the utilization of natural polymers for the fabrication of tunable DDSs owing to their biocompatible, biodegradable, and non-toxic nature can be regarded as a significant stride in the field of drug delivery. Marine environment serves as an untapped resource of varied range of materials such as polysaccharides, which can easily be utilized for developing various DDSs. Methods: Carrageenans are the sulfated polysaccharides that are extracted from the cell wall of red seaweeds. They exhibit an assimilation of various biological activities such as anti-thrombotic, anti-viral, anticancer, and immunomodulatory properties. The main aim of the presented review is threefold. The first one is to describe the unique physicochemical properties and structural composition of different types of carrageenans. The second is to illustrate the preparation methods of the different carrageenan-based macro- and micro-dimensional DDSs like hydrogels, microparticles, and microspheres respectively. Fabrication techniques of some advanced DDSs such as floating hydrogels, aerogels, and 3-D printed hydrogels have also been discussed in this review. Next, considerable attention has been paid to list down the recent applications of carrageenan-based polymeric architectures in the field of drug delivery. Results: Presence of structural variations among the different carrageenan types helps in regulating their temperature and ion-dependent sol-to-gel transition behavior. The constraint of low mechanical strength of reversible gels can be easily eradicated using chemical crosslinking techniques. Carrageenan based-microdimesional DDSs (e.g. microspheres, microparticles) can be utilized for easy and controlled drug administration. Moreover, carrageenans can be fabricated as 3-D printed hydrogels, floating hydrogels, and aerogels for controlled drug delivery applications. Conclusion: In order to address the problems associated with many of the available DDSs, carrageenans are establishing their worth recently as potential drug carriers owing to their varied range of properties. Different architectures of carrageenans are currently being explored as advanced DDSs. In the near future, translation of carrageenan-based advanced DDSs in the clinical applications seems inevitable.

Facile Synthesis of Multivalent Nitrilotriacetic Acid (NTA) and NTA Conjugates for Analytical and Drug Delivery Applications

2006 ◽  
Vol 17 (6) ◽  
pp. 1592-1600 ◽  
Author(s):  
Zhaohua Huang ◽  
Joshua I. Park ◽  
Douglas S. Watson ◽  
Peter Hwang ◽  
Francis C. Szoka
Keyword(s):  
Drug Delivery ◽  
Nitrilotriacetic Acid ◽  
Facile Synthesis ◽  
Drug Delivery Applications

Synthesis of Functional Core, Star Polymers via RAFT Polymerization for Drug Delivery Applications

2012 ◽  
Vol 33 (9) ◽  
pp. 760-766 ◽  
Author(s):  
Jinna Liu ◽  
Hien Duong ◽  
Michael R. Whittaker ◽  
Thomas P. Davis ◽  
Cyrille Boyer
Keyword(s):  
Drug Delivery ◽  
Raft Polymerization ◽  
Star Polymers ◽  
Drug Delivery Applications
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