Self-assembled micelles of a multi-functional amphiphilic fusion (MFAF) peptide for targeted cancer therapy

2015 ◽  
Vol 6 (18) ◽  
pp. 3512-3520 ◽  
Author(s):  
Yin-Jia Cheng ◽  
Hong Cheng ◽  
Xin Zhao ◽  
Xiao-Ding Xu ◽  
Ren-Xi Zhuo ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Tumor Cells ◽  
Tumor Targeting ◽  
Targeted Cancer Therapy ◽  
Self Assembled

A new MFAF peptide was designed and prepared. The micelles of this MFAF peptide can efficiently use their tumor-targeting, membrane-penetrating and endosome-escaping functions to deliver the drug into targeted tumor cells, leading to the apoptosis of tumor cells.

pH-Responsive de-PEGylated nanoparticles based on triphenylphosphine–quercetin self-assemblies for mitochondria-targeted cancer therapy

2017 ◽  
Vol 53 (62) ◽  
pp. 8790-8793 ◽  
Author(s):  
Lei Xing ◽  
Jin-Yuan Lyu ◽  
Yue Yang ◽  
Peng-Fei Cui ◽  
Liu-Qing Gu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Coordination Bond ◽  
The Self ◽  
Targeted Cancer Therapy ◽  
Ph Responsive ◽  
Pegylated Nanoparticles ◽  
Self Assembled

The self-assembled nanosystem formulated with amphiphilic TPP–Que and PBA–PEG through a coordination bond could balance the dilemma of PEGylation.

Host-cell-assisted construction of folate-engineered nanocarrier based on viral light particle for targeted cancer therapy

Nanoscale ◽  
2021 ◽  
Author(s):  
Cheng Lv ◽  
Jian Ao ◽  
Ji Wang ◽  
Man Tang ◽  
An-An Liu ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Therapy ◽  
Host Cell ◽  
Tumor Targeting ◽  
Light Particle ◽  
Targeted Cancer Therapy ◽  
Normal Cells ◽  
Specific Tumor

Targeted cancer therapy has aroused broad interests of researchers due to its accuracy in specific tumor targeting and few side effects on normal cells. In the last decades, oncolytic viral...

Fetoprotein Derived Short Peptide Coated Nanostructured Amphiphilic Surfaces for Targeting Mouse Breast Cancer Cells

2017 ◽  
Vol 16 (01) ◽  
pp. 1650023
Author(s):  
Alexandra M. Brown ◽  
Yoliem S. Miranda-Alarćon ◽  
Grant A. Knoll ◽  
Anthony M. Santora ◽  
Ipsita A. Banerjee
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Tumor Cells ◽  
Tumor Targeting ◽  
Breast Cancer Cells ◽  
Chemotherapeutic Drug ◽  
Short Peptide ◽  
Mouse Breast Cancer ◽  
Self Assembled

In this work, self-assembled tumor targeting nanostructured surfaces were developed from a newly designed amphiphile by conjugating boc protected isoleucine with 2,[Formula: see text] ethylenedioxy bis ethylamine (IED). To target mouse mammary tumor cells, a short peptide sequence derived from the human alpha-fetoprotein (AFP), LSEDKLLACGEG was attached to the self-assembled nanostructures. Tumor targeting and cell proliferation were examined in the presence of nanoscale assemblies. To further obliterate mouse breast tumor cells, the chemotherapeutic drug tamoxifen was then entrapped into the nanoassemblies. Our studies indicated that the targeting systems were able to efficiently encapsulate and release tamoxifen. Cell proliferation studies showed that IED-AFP peptide loaded with tamoxifen decreased the proliferation of breast cancer cells while in the presence of the IED-AFP peptide nanoassemblies alone, the growth was relatively slower. In the presence of human dermal fibroblasts however cell proliferation continued similar to controls. Furthermore, the nanoscale assemblies were found to induce apoptosis in mouse breast cancer cells. To examine live binding interactions, SPR analysis revealed that tamoxifen encapsulated IED-AFP peptide nanoassemblies bound to the breast cancer cells more efficiently compared to unencapsulated assemblies. Thus, we have developed nanoscale assemblies that can specifically bind to and target tumor cells, with increased toxicity in the presence of a chemotherapeutic drug.

Enzymatic activatable self-assembled peptide nanowire for targeted therapy and fluorescence imaging of tumors

2016 ◽  
Vol 52 (18) ◽  
pp. 3631-3634 ◽  
Author(s):  
Ying Tang ◽  
Zhan Wu ◽  
Chong-Hua Zhang ◽  
Xiao-Li Zhang ◽  
Jian-Hui Jiang
Keyword(s):  
Targeted Therapy ◽  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Cytotoxic Agents ◽  
Targeted Cancer Therapy ◽  
Self Assembled

An activatable theranostic approach based on self-assembled peptide nanostructures with surface-displayed activatable cytotoxic agents for targeted cancer therapy was developed.

Genetically engineered and self-assembled oncolytic protein nanoparticles for targeted cancer therapy

Biomaterials ◽  
2017 ◽  
Vol 120 ◽  
pp. 22-31 ◽  
Author(s):  
Joong-jae Lee ◽  
Jung Ae Kang ◽  
Yiseul Ryu ◽  
Sang-Soo Han ◽  
You Ree Nam ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Genetically Engineered ◽  
Targeted Cancer Therapy ◽  
Protein Nanoparticles ◽  
Self Assembled

Self-assembled nanoparticles comprising aptide–SN38 conjugates for use in targeted cancer therapy

2016 ◽  
Vol 27 (48) ◽  
pp. 48LT01 ◽  
Author(s):  
Hyungjun Kim ◽  
Yonghyun Lee ◽  
Sukmo Kang ◽  
Minsuk Choi ◽  
Soyoung Lee ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy ◽  
Self Assembled

Tumor-Targeting, pH-Responsive, and Stable Unimolecular Micelles as Drug Nanocarriers for Targeted Cancer Therapy

2010 ◽  
Vol 21 (3) ◽  
pp. 496-504 ◽  
Author(s):  
Xiaoqiang Yang ◽  
Jamison J. Grailer ◽  
Srikanth Pilla ◽  
Douglas A. Steeber ◽  
Shaoqin Gong
Keyword(s):  
Cancer Therapy ◽  
Tumor Targeting ◽  
Targeted Cancer Therapy ◽  
Ph Responsive ◽  
Drug Nanocarriers

scholarly journals Hyaluronic Acid-Based Theranostic Nanomedicines for Targeted Cancer Therapy

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 940 ◽  
Author(s):  
So Yun Lee ◽  
Moon Sung Kang ◽  
Woo Yeup Jeong ◽  
Dong-Wook Han ◽  
Ki Su Kim
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Binding Affinity ◽  
Anticancer Drugs ◽  
Cancer Therapies ◽  
Targeted Cancer Therapy ◽  
Cancer Treatments ◽  
High Binding Affinity

Hyaluronic acid (HA) is a natural mucopolysaccharide and has many useful advantages, including biocompatibility, non-immunogenicity, chemical versatility, non-toxicity, biodegradability, and high hydrophilicity. Numerous tumor cells overexpress several receptors that have a high binding affinity for HA, while these receptors are poorly expressed in normal body cells. HA-based drug delivery carriers can offer improved solubility and stability of anticancer drugs in biological environments and allow for the targeting of cancer treatments. Based on these benefits, HA has been widely investigated as a promising material for developing the advanced clinical cancer therapies in various formulations, including nanoparticles, micelles, liposomes, and hydrogels, combined with other materials. We describe various approaches and findings showing the feasibility of improvement in theragnosis probes through the application of HA.

Sign in / Sign up

Export Citation Format

Share Document