Porphyrin-containing amphiphilic block copolymers for photodynamic therapy

2015 ◽  
Vol 6 (15) ◽  
pp. 2945-2954 ◽  
Author(s):  
Lei Xu ◽  
Lichao Liu ◽  
Feng Liu ◽  
Haibo Cai ◽  
Weian Zhang
Keyword(s):  
Photodynamic Therapy ◽  
Block Copolymers ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers

Amphiphilic PNIPAM-b-PTPPC6MA block copolymers as promising photosensitizers for photodynamic therapy (PDT) constructed using porphyrin-containing monomers via RAFT polymerization.

One-step synthesis of poly(2-oxazoline)-based amphiphilic block copolymers using a dual initiator for RAFT polymerization and CROP

Polymer ◽  
2014 ◽  
Vol 55 (23) ◽  
pp. 5986-5990 ◽  
Author(s):  
Young Chang Yu ◽  
Hang Sung Cho ◽  
Woong-Ryeol Yu ◽  
Ji Ho Youk
Keyword(s):  
Block Copolymers ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
One Step

Synthesis of amphiphilic block copolymers based on poly(dimethylsiloxane) via fragmentation chain transfer (RAFT) polymerization

Polymer ◽  
2004 ◽  
Vol 45 (13) ◽  
pp. 4383-4389 ◽  
Author(s):  
Tommy S.C Pai ◽  
Christopher Barner-Kowollik ◽  
Thomas P Davis ◽  
Martina H Stenzel
Keyword(s):  
Block Copolymers ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers

scholarly journals Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5147
Author(s):  
Wanting Hou ◽  
Ruiqi Liu ◽  
Siwei Bi ◽  
Qian He ◽  
Haibo Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery System ◽  
Delivery System ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Medical Applications ◽  
Drug Molecules ◽  
Reversible Addition ◽  
Raft Agent

Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (N,N’-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy.

Fluorinated amphiphilic block copolymers via RAFT polymerization and their application as surf-RAFT agent in miniemulsion polymerization

RSC Advances ◽  
2015 ◽  
Vol 5 (20) ◽  
pp. 15461-15468 ◽  
Author(s):  
Bishnu P. Koiry ◽  
Arindam Chakrabarty ◽  
Nikhil K. Singha
Keyword(s):  
Block Copolymer ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Raft Polymerization ◽  
Miniemulsion Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Poly Ethylene Glycol ◽  
Raft Agent ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Preparation of an amphiphilic block copolymer (Am-BCP) based on poly(ethylene glycol) methyl ether methacrylate (PEGMA) and heptafluorobutyl acrylate (HFBA) via RAFT polymerization and application of this Am-BCP as surf-RAFT agent for polymerization of styrene.

Photosensitizer localization in amphiphilic block copolymers controls photodynamic therapy efficacy

Nanoscale ◽  
2017 ◽  
Vol 9 (31) ◽  
pp. 11180-11186 ◽  
Author(s):  
Vusala Ibrahimova ◽  
Sergey A. Denisov ◽  
Kevin Vanvarenberg ◽  
Peter Verwilst ◽  
Véronique Préat ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Block Copolymers ◽  
Amphiphilic Block Copolymers ◽  
Therapy Efficacy

The localization of the photosensitizer conjugation site in amphiphilic block copolymers has a great impact on photodynamic therapy efficiency.

Analysis of Thiol-sensitive Core-cross-linked Polymeric Micelles Carrying Nucleoside Pendant Groups using 'On-line' Methods: Effect of Hydrophobicity on Cross-linking and Degradation

2011 ◽  
Vol 64 (6) ◽  
pp. 766 ◽  
Author(s):  
Bianca M. Blunden ◽  
Donald S. Thomas ◽  
Martina H. Stenzel
Keyword(s):  
Block Copolymers ◽  
Polymeric Micelles ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Cross Linking ◽  
Copolymer Composition ◽  
Reversible Addition ◽  
On Line ◽  
Styrene Content ◽  
Poly Ethylene

Amphiphilic block copolymers were prepared via reversible–addition fragmentation chain transfer (RAFT) polymerization and their synthesis, cross-linking, and degradation were studied using on-line monitoring. The focus of this work is the systematic alteration of the hydrophobic block using copolymers based on 5′-O-methacryloyluridine (MAU) and styrene at different compositions to determine the effect of the copolymer composition on the properties of the micelle. A poly(poly(ethylene glycol) methyl ether methacrylate) (PEGMA) macroRAFT agent was chain extended with a mixture of styrene and MAU. In both systems, an increasing fraction of styrene was found to reduce the rate of polymerization, but the functionality of the RAFT system was always maintained. The amphiphilic block copolymers were dialyzed against water to generate micelles with sizes between 17 and 25 nm according to dynamic light scattering (DLS). Increasing styrene content lead to smaller micelles (determined by DLS and transmission electron microscopy) and to lower critical micelle concentrations, which was measured using surface tensiometry. The micelles were further stabilized via core-cross-linking using bis(2-methacroyloxyethyl) disulfide as crosslinker. NMR analysis revealed a faster consumption of crosslinker with higher styrene content. These stable cross-linked micelles were investigated regarding their ability to degrade in the presence of dithiothreitol as a model reductant. Increasing the styrene content resulted in a faster degradation of the cross-linked micelles into unimers.

Synthesis and self-assembly behaviors of three-armed amphiphilic block copolymers via RAFT polymerization

Polymer ◽  
2008 ◽  
Vol 49 (21) ◽  
pp. 4569-4575 ◽  
Author(s):  
Weidong Zhang ◽  
Wei Zhang ◽  
Nianchen Zhou ◽  
Zhenping Cheng ◽  
Jian Zhu ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Self Assembly ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers
Sign in / Sign up

Export Citation Format

Share Document