p53 family members – important messengers in cell death signaling in photodynamic therapy of cancer?

2015 ◽  
Vol 14 (8) ◽  
pp. 1390-1396 ◽  
Author(s):  
Pilar Acedo ◽  
Joanna Zawacka-Pankau
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Cellular Stress ◽  
Family Members ◽  
P53 Family ◽  
Photodynamic Therapy Of Cancer ◽  
Cell Death Signaling

p53 is a powerful tumor suppressor and a critical sensor of cellular stress. This Perspective summarizes the role of p53 in response of cancer cells to photodynamic therapy – a field not fully explored yet.

scholarly journals Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells

2018 ◽  
Author(s):  
Alicja Sznarkowska ◽  
Anna Kostecka ◽  
Anna Kawiak ◽  
Pilar Acedo ◽  
Mattia Lion ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Practice ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
Drug Repurposing ◽  
Functional Similarity ◽  
Photodynamic Therapy Of Cancer

AbstractBackgroundThe p73 protein is a tumor suppressor that shares structural and functional similarity with p53. p73 is expressed in two major isoforms; the TA isoform that interacts with p53 pathway, thus acting as tumor suppressor and the N-terminal truncated ΔN isoform that inhibits TAp73 and p53 and thus, acts as an oncogene.ResultsBy employing a drug repurposing approach, we found that protoporphyrin IX (PpIX), a metabolite of aminolevulinic acid (ALA) applied in photodynamic therapy of cancer, stabilizes TAp73 and activates TAp73-dependent apoptosis in cancer cells lacking p53. The mechanism of TAp73 activation is via disruption of TAp73/MDM2 and TAp73/MDMX interactions and inhibition of TAp73 degradation by ubiquitin ligase Itch.ConclusionOur findings may in future contribute to the successful repurposing of PpIX into clinical practice.

Exploring the Role of Phytochemicals as Potent Natural Photosensitizers in Photodynamic Therapy

2020 ◽  
Vol 20 (15) ◽  
pp. 1831-1844 ◽  
Author(s):  
Giftson J. Senapathy ◽  
Blassan P. George ◽  
Heidi Abrahamse
Keyword(s):  
Cell Death ◽  
Photodynamic Therapy ◽  
Cancer Treatments ◽  
Cancer Cell Death ◽  
Clinical Investigations ◽  
Cell Death Signaling ◽  
Deadly Disease ◽  
Treatment Procedures ◽  
Apoptosis And Necrosis

Background: Cancer is still considered a deadly disease worldwide due to difficulties in diagnosis, painful treatment procedures, costly therapies, side effects, and cancer relapse. Cancer treatments using conventional methods like chemotherapy and radiotherapy were not convincing due to its post-treatment toxicity in the host. In Photodynamic Therapy (PDT), three individual non-toxic components including a photosensitizer, light source and oxygen cause damage to the cells and tissues when they are combined. Objective: In recent years, phytochemicals are being increasingly recognized as potent complementary drugs for cancer because of its natural availability, less toxicity and therapeutic efficiency in par with commercial drugs. Hence, the idea of using phytochemicals as natural photosensitizers in PDT resulted in a multiple pool of research studies with promising results in preclinical and clinical investigations. Methods: In this review, the potential of phytochemicals to act as natural photosensitizers for PDT, their mode of action, drawbacks, challenges and possible solutions are discussed in detail. Results: In PDT, natural photosensitizers, when used alone or in combination with other photosensitizers, induced cell death by apoptosis and necrosis, increased oxidative stress, altered cancer cell death signaling pathways, increased cytotoxicity and DNA damage in cancer cells. The pro-oxidant nature of certain antioxidant polyphenols, hormesis phenomenon, Warburg effect and DNA damaging potential plays a significant role in the photosensitizing mechanism of phytochemicals in PDT. Conclusion: This review explores the role of phytochemicals that can act as photosensitizers alone or in combination with PDT and its mechanism of action on different cancers.

Relevance of mitochondrial dysfunction during Sorafenib-induced cell death in liver cancer cells. Role of oxidative and nitrogen reactive species

2021 ◽  
Vol 165 ◽  
pp. 54
Author(s):  
Patricia de la Cruz-Ojeda ◽  
M. Ángeles Rodríguez-Hernández ◽  
Elena Navarro-Villarán ◽  
Paloma Gallego ◽  
Pavla Staňková ◽  
...  
Keyword(s):  
Cell Death ◽  
Liver Cancer ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Reactive Species ◽  
Liver Cancer Cells ◽  
Nitrogen Reactive Species

Combination of photodynamic therapy with doxorubicin in osteosarcoma: Cell death and the role of oxidative stress

2016 ◽  
Vol 61 ◽  
pp. S141
Author(s):  
B. Serambeque ◽  
G. Brites ◽  
M. Laranjo ◽  
G. Chohfi de Miguel ◽  
A. Serra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Death ◽  
Photodynamic Therapy ◽  
Osteosarcoma Cell

Multimodal Upconversion Nanoplatform with a Mitochondria-Targeted Property for Improved Photodynamic Therapy of Cancer Cells

2016 ◽  
Vol 55 (8) ◽  
pp. 3872-3880 ◽  
Author(s):  
Xiaoman Zhang ◽  
Fujin Ai ◽  
Tianying Sun ◽  
Feng Wang ◽  
Guangyu Zhu
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Photodynamic Therapy Of Cancer

Selenorhodamine photosensitizers with the Texas-red core for photodynamic therapy of cancer cells

2015 ◽  
Vol 23 (15) ◽  
pp. 4501-4507 ◽  
Author(s):  
Mark W. Kryman ◽  
Kellie S. Davies ◽  
Michelle K. Linder ◽  
Tymish Y. Ohulchanskyy ◽  
Michael R. Detty
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Photodynamic Therapy Of Cancer ◽  
Red Core ◽  
Texas Red
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