Antimalarial activity of novel 4-cyano-3-methylisoquinoline inhibitors against Plasmodium falciparum: design, synthesis and biological evaluation

2016 ◽  
Vol 14 (20) ◽  
pp. 4617-4639 ◽  
Author(s):  
Melissa J. Buskes ◽  
Katherine L. Harvey ◽  
Benjamin J. Richards ◽  
Robabeh Kalhor ◽  
Rebecca M. Christoff ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Antimalarial Activity ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Erythrocyte Invasion ◽  
Synthesis And Biological Evaluation

A series of 4-cyano-3-methylisoquinolines have been shown to inhibit parasite cytokinesis and erythrocyte invasion.

scholarly journals Synthesis and Biological Evaluation of Febrifugine Analogues

2014 ◽  
Vol 9 (12) ◽  
pp. 1934578X1400901
Author(s):  
Huong Doan Thi Mai ◽  
Giang Vo Thanh ◽  
Van Hieu Tran ◽  
Van Nam Vu ◽  
Van Loi Vu ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Cell Lines ◽  
Cancer Cell ◽  
Antimalarial Activity ◽  
Biological Evaluation ◽  
Strong Inhibition ◽  
Synthetic Analogues ◽  
Synthetic Compounds ◽  
Activity Evaluation ◽  
Synthesis And Biological Evaluation

A series of febrifugine analogues were designed and synthesized. Antimalarial activity evaluation of the synthetic compounds indicated that these derivatives had a strong inhibition against both chloroquine-sensitive and -resistant Plasmodium falciparum parasites. Many of them were found to be more active than febrifugine hydrochloride. The tested analogues had also a significant cytotoxicity against four cancer cell lines (KB, MCF7, LU1 and HepG2). Among the synthetic analogues, two compounds 17b and 17h displayed a moderate cytotoxicity while they exhibited a remarkable antimalarial activity.

ChemInform Abstract: The Design, Synthesis and Biological Evaluation of Stable Ozonides with Antimalarial Activity.

ChemInform ◽  
2010 ◽  
Vol 27 (36) ◽  
pp. no-no
Author(s):  
L.-C. DE ALMEIDA BARBOSA ◽  
D. CUTLER ◽  
J. MANN ◽  
M. J. CRABBE ◽  
G. C. KIRBY ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

The design, synthesis and biological evaluation of stable ozonides with antimalarial activity

1996 ◽  
pp. 1101 ◽  
Author(s):  
Luiz-Claudio de Almeida Barbosa ◽  
David Cutler ◽  
John Mann ◽  
M. James Crabbe ◽  
Geoffrey C. Kirby ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine

2017 ◽  
Vol 11 (1) ◽  
Author(s):  
Mallika Pathak ◽  
Himanshu Ojha ◽  
Anjani K. Tiwari ◽  
Deepti Sharma ◽  
Manisha Saini ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

scholarly journals Synthesis and Biological Evaluation of Novel Thiazole Hydrazines as Antimicrobial and Antimalarial Agents

2020 ◽  
Vol 10 (1) ◽  
pp. 1846-1855
Keyword(s):  
Plasmodium Falciparum ◽  
Spectral Analysis ◽  
Antimalarial Activity ◽  
Biological Evaluation ◽  
Phenacyl Bromide ◽  
Good Activity ◽  
E Coli ◽  
Fungal Strains ◽  
Antimalarial Agents ◽  
Synthesis And Biological Evaluation

Synthesis of some novel thiazole hydrazine derivatives from thiosemicarbazones of salicylaldehyde and 5-chlorosalicylaldehyde with phenacyl bromide in ethanol under reflux condition is reported. The synthesized compounds were characterized by spectral analysis and further screened against - S. aureus, E. coli, P. aeruginosa, S. pyogenus bacteria, and against C. albicans, A. clavatus, and A. niger fungal strains. Most of the compounds were active against E. coli and C. albicans. Antimalarial screening against Plasmodium falciparum showed moderate to the good activity of the synthesized compounds but less than the standard quinine. One of the synthesized compounds (4c) exhibited promising antimalarial activity against Plasmodium falciparum with IC50 close to the standard quinine.

Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties

2012 ◽  
Vol 9 (2) ◽  
pp. 140-152 ◽  
Author(s):  
Romeo Romagnoli ◽  
Pier Giovanni Baraldi ◽  
Olga Cruz-Lopez ◽  
Maria Kimatrai Salvador ◽  
Delia Preti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Hybrid Molecules ◽  
Synthesis And Biological Evaluation

Design, Synthesis and Biological Evaluation of Novel Aminosaccharide Derivatives of Combretastatin A-4

2013 ◽  
Vol 10 (10) ◽  
pp. 935-941
Author(s):  
Yan Tang ◽  
Zhewei Tu ◽  
Jing Sun ◽  
Xiong Zhu ◽  
Kun Liu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of
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