Gem-difluoromethylated and trifluoromethylated derivatives of DMDP-related iminosugars: synthesis and glycosidase inhibition

2016 ◽  
Vol 14 (7) ◽  
pp. 2249-2263 ◽  
Author(s):  
Yi-Xian Li ◽  
Kyoko Kinami ◽  
Yuki Hirokami ◽  
Atsushi Kato ◽  
Jia-Kun Su ◽  
...  

Gem-difluoromethylated and trifluoromethylated derivatives of DMDP-related iminosugars have been synthesized from cyclic nitrones and assayed against various glycosidases.

2015 ◽  
Vol 80 (10) ◽  
pp. 5151-5158 ◽  
Author(s):  
Yi-Xian Li ◽  
Yousuke Shimada ◽  
Isao Adachi ◽  
Atsushi Kato ◽  
Yue-Mei Jia ◽  
...  

2020 ◽  
Vol 18 (5) ◽  
pp. 999-1011 ◽  
Author(s):  
Lin-Feng Yang ◽  
Yuna Shimadate ◽  
Atsushi Kato ◽  
Yi-Xian Li ◽  
Yue-Mei Jia ◽  
...  

Four series of N-substituted DIMs have been synthesized and assayed against glycosidases to provide continuous and reliable inhibitory spectra.


2016 ◽  
Vol 14 (22) ◽  
pp. 5157-5174 ◽  
Author(s):  
Ying-Ying Song ◽  
Kyoko Kinami ◽  
Atsushi Kato ◽  
Yue-Mei Jia ◽  
Yi-Xian Li ◽  
...  

Broussonetine W and its 11 analogues have been first synthesized from cyclic nitrones and assayed as potential gycosidase inhibitors.


1982 ◽  
Vol 85 (1) ◽  
pp. 257-263 ◽  
Author(s):  
A. Graja ◽  
M. Przybylski ◽  
B. Butka ◽  
R. Swietlik

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