Catalytic asymmetric hetero-Diels–Alder reactions of enones with isatins to access functionalized spirooxindole tetrahydropyrans: scope, derivatization, and discovery of bioactives

2016 ◽  
Vol 14 (5) ◽  
pp. 1777-1783 ◽  
Author(s):  
Hai-Lei Cui ◽  
Pandurang V. Chouthaiwale ◽  
Feng Yin ◽  
Fujie Tanaka
Keyword(s):  
Diels Alder ◽  
Bioactive Molecules ◽  
Catalytic Asymmetric

Concise hetero-Diels–Alder reactions were developed to provide various functionalized spirooxindole tetrahydropyrans useful for the discovery of bioactive molecules.

Catalytic Asymmetric Aza‐Diels‐Alder Reaction of Ketimines and Unactivated Dienes

2021 ◽  
Author(s):  
Xin Li ◽  
Qun Zhao ◽  
Yao Li ◽  
Qing-Xia Zhang ◽  
Jin-Pei Cheng
Keyword(s):  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction ◽  
Catalytic Asymmetric

Catalytic Asymmetric Total Synthesis of (+)- and (−)-Paeoveitol via a Hetero-Diels–Alder Reaction

2017 ◽  
Vol 19 (3) ◽  
pp. 429-431 ◽  
Author(s):  
Tian-Ze Li ◽  
Chang-An Geng ◽  
Xiu-Juan Yin ◽  
Tong-Hua Yang ◽  
Xing-Long Chen ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Alder Reaction ◽  
Diels Alder ◽  
Asymmetric Total Synthesis ◽  
Diels Alder Reaction ◽  
Catalytic Asymmetric

Reactivity and Efficient Recycling of a Chiral Pd-BINAP Catalyst for Catalytic Asymmetric Diels-Alder Reaction in Ionic Liquid

Heterocycles ◽  
2009 ◽  
Vol 77 (2) ◽  
pp. 1323 ◽  
Author(s):  
Hiroto Nakano ◽  
Mitsuhiro Takeshita ◽  
Yasuhiro Nishiuchi ◽  
Yuta Araki ◽  
Reiko Fujita ◽  
...  
Keyword(s):  
Ionic Liquid ◽  
Alder Reaction ◽  
Diels Alder ◽  
Diels Alder Reaction ◽  
Catalytic Asymmetric

scholarly journals Combining enyne metathesis with long-established organic transformations: a powerful strategy for the sustainable synthesis of bioactive molecules

2020 ◽  
Vol 16 ◽  
pp. 738-755
Author(s):  
Valerian Dragutan ◽  
Ileana Dragutan ◽  
Albert Demonceau ◽  
Lionel Delaude
Keyword(s):  
Therapeutic Agents ◽  
Ruthenium Catalysts ◽  
Diels Alder ◽  
Bioactive Molecules ◽  
Enyne Metathesis ◽  
Organic Transformations ◽  
Chemically Modified ◽  
Key Steps ◽  
Powerful Strategy

This account surveys the current progress on the application of intra- and intermolecular enyne metathesis as main key steps in the synthesis of challenging structural motifs and stereochemistries found in bioactive compounds. Special emphasis is placed on ruthenium catalysts as promoters of enyne metathesis to build the desired 1,3-dienic units. The advantageous association of this approach with name reactions like Grignard, Wittig, Diels–Alder, Suzuki–Miyaura, Heck cross-coupling, etc. is illustrated. Examples unveil the generality of such tandem reactions in providing not only the intricate structures of known, in vivo effective substances but also for designing chemically modified analogs as valid alternatives for further therapeutic agents.

Catalytic Asymmetric Hetero Diels–Alder Reactions ofN-Sulfinyl Dienophiles with Chiral Bis(oxazoline)copper(II) and -zinc(II) Triflates

2006 ◽  
Vol 2006 (23) ◽  
pp. 5249-5259 ◽  
Author(s):  
Molla Mellese Endeshaw ◽  
Annette Bayer ◽  
Lars K. Hansen ◽  
Odd R. Gautun
Keyword(s):  
Diels Alder ◽  
Catalytic Asymmetric
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