Direct synthesis of C-glycosides from unprotected 2-N-acyl-aldohexoses via aldol condensation–oxa-Michael reactions with unactivated ketones

2016 ◽  
Vol 14 (1) ◽  
pp. 259-264 ◽  
Author(s):  
Sherida Johnson ◽  
Fujie Tanaka
Keyword(s):  
Aldol Condensation ◽  
Direct Synthesis ◽  
One Pot ◽  
Michael Reactions

C-glycosides were synthesized from unprotected 2-N-acyl-aldohexoses and unactivated ketones in one pot via aldol condensation–oxa-Michael reactions.

One-pot synthesis of cyclohexylamine and N-aryl pyrroles via hydrogenation of nitroarenes over the Pd0.5Ru0.5-PVP catalyst

2021 ◽  
Author(s):  
Chandan Chaudhari ◽  
Katsutoshi Sato ◽  
Yasuyuki Ikeda ◽  
Kenji Terada ◽  
Naoya Abe ◽  
...  
Keyword(s):  
Direct Synthesis ◽  
One Pot ◽  
One Pot Synthesis

The direct synthesis of cyclohexylamine via hydrogenation of nitrobenzene over monometallic (Pd, Ru or Rh) and bimetallic (PdxRu1−x) catalysts was studied.

scholarly journals 2-Aryl-6-Polyfluoroalkyl-4-Pyrones as Promising RF-Building-Blocks: Synthesis and Application for Construction of Fluorinated Azaheterocycles

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4415
Author(s):  
Sergey A. Usachev ◽  
Diana I. Nigamatova ◽  
Daria K. Mysik ◽  
Nikita A. Naumov ◽  
Dmitrii L. Obydennov ◽  
...  
Keyword(s):  
Direct Synthesis ◽  
Building Blocks ◽  
Oxidative Cyclization ◽  
One Pot ◽  
Synthetic Application ◽  
General Method

A convenient and general method for the direct synthesis of 2-aryl-6-(trifluoromethyl)-4-pyrones and 2-aryl-5-bromo-6-(trifluoromethyl)-4-pyrones has been developed on the basis of one-pot oxidative cyclization of (E)-6-aryl-1,1,1-trifluorohex-5-ene-2,4-diones via a bromination/dehydrobromination approach. This strategy was also applied for the preparation of 2-phenyl-6-polyfluoroalkyl-4-pyrones and their 5-bromo derivatives. Conditions of chemoselective enediones bromination were found and the key intermediates of the cyclization of bromo-derivatives to 4-pyrones were characterized. Synthetic application of the prepared 4-pyrones has been demonstrated for the construction of biologically important CF3-bearing azaheterocycles, such as pyrazoles, pyridones, and triazoles.

scholarly journals Synthesis and Cytotoxic Activity of Several Novel N-Alkyl-Plinabulin Derivatives With Aryl Group Moieties

2021 ◽  
Vol 16 (4) ◽  
pp. 1934578X2110100
Author(s):  
Pham The Chinh ◽  
Pham Thi Tham ◽  
Duong Huong Quynh ◽  
Nguyen Van Tuyen ◽  
Dinh Thuy Van ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Aldol Condensation ◽  
One Pot ◽  
Aryl Group ◽  
Vascular Disrupting Agents ◽  
Benzaldehyde Derivatives ◽  
Vascular Disrupting

Seven novel N-alkyl-plinabulin derivatives with aryl groups moieties (nitroquinoline, 1,4-dihydroquinoline, 4-methoxybenzene, and 4-chlorobenzene) have been synthesized via aldol condensation and alkylation in one-pot, and tested for their cytotoxicity against 4 cancer cell lines (KB, HepG2, Lu, and MCF7). Compounds ( Z)−3-((6,8-dimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)piperazine-2,5-dione (5a), ( Z)−6-(( Z)−4-methoxybenzylidene)−1-(prop-2-yn-1-yl)−3-((1,6,8-trimethyl-4-oxo-1,4-dihydroquinolin-2-yl)methylene)piperazine-2,5-dione (5b), and ( Z)−3-(( Z)−4-chlorobenzylidene)−1,4-dimethyl-6-((8-methyl-4-nitroquinolin-2-yl)methylene)piperazine-2,5-dione (8) showed strong cytotoxicity against 3 of the cancer cells lines (KB, HepG2 and Lu) with IC50 values ranging from 3.04 to 10.62 µM. The quinoline-derived compounds had higher cytotoxic activity than the benzaldehyde derivatives. The successful synthesis of these derivatives offers useful information for the development of more potent vascular disrupting agents based on plinabulin.

Cu-catalyzed C–H Activation Reaction: One Pot Direct Synthesis of Xanthine and Uric Acid Derivatives from 5-Bromo Uracil

Synlett ◽  
2021 ◽  
Author(s):  
Habibur Rahaman ◽  
Brindaban Roy ◽  
Somjit Hazra ◽  
Biplab Mondal
Keyword(s):  
Uric Acid ◽  
Bond Activation ◽  
Direct Synthesis ◽  
One Pot ◽  
Activation Reaction

Abstract: A one pot direct synthesis of xanthine and uric acid derivates is reported. This simple yet efficient methodology illustrates concurrent formation of two C-N bonds using CuBr2 as catalyst and one of those C-N bonds is formed by uracil C6-H bond activation.

Catalyst-Free One-Pot Synthesis of Novel Heteroarylamine Substituted Furo[3,2-c]coumarins

Synlett ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 1589-1592 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Mahnaz Saraei ◽  
Reyhaneh Khoeiniha
Keyword(s):  
Michael Addition ◽  
Aldol Condensation ◽  
Ring Closure ◽  
Dehydration Reaction ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Tandem Process ◽  
First Time

A high-yielding cyclocondensation of 4-hydroxycoumarin, phenylglyoxal monohydrate, and heteroarylamines proceeds without catalysis, which gives novel functionalized furo[3,2-c]coumarins and heteroarylamino alkylation of coumarin products in acetonitrile under reflux, is reported for the first time. This tandem process involves sequentially an aldol condensation, Michael addition, a ring closure, and dehydration reaction.

Direct synthesis of size-tunable PbS nanocubes and octahedra and the pH effect on crystal shape control

2015 ◽  
Vol 44 (34) ◽  
pp. 15088-15094 ◽  
Author(s):  
Hsiang-Sheng Chen ◽  
Szu-Chieh Wu ◽  
Michael H. Huang
Keyword(s):  
Shape Control ◽  
Ph Effect ◽  
Direct Synthesis ◽  
Crystal Shape ◽  
One Pot ◽  
Pbs Nanocrystals

Small PbS nanocrystals were synthesized by a one-pot procedure, but large octahedra were produced by changing the reagent introduction sequence.

Direct synthesis of pterocarpans via aldol condensation of phenylacetates with benzaldehydes

Tetrahedron ◽  
1999 ◽  
Vol 55 (40) ◽  
pp. 11773-11786 ◽  
Author(s):  
Theunis G. van Aardt ◽  
Hendrik van Rensburg ◽  
Daneel Ferreira
Keyword(s):  
Aldol Condensation ◽  
Direct Synthesis

A new aldol condensation of .alpha.-allenic esters with aldehydes, including a one-pot synthesis of enyne compounds

1993 ◽  
Vol 58 (22) ◽  
pp. 5952-5957 ◽  
Author(s):  
Sadao Tsuboi ◽  
Hirofumi Kuroda ◽  
Satoshi Takatsuka ◽  
Takashi Fukawa ◽  
Takashi Sakai ◽  
...  
Keyword(s):  
Aldol Condensation ◽  
One Pot ◽  
One Pot Synthesis ◽  
Allenic Esters

On the Necessity of One-Pot Tautomer Trapping in Asymmetric Michael Reactions of Arylideneisoxazol-5-ones

2020 ◽  
Vol 2020 (15) ◽  
pp. 2264-2270 ◽  
Author(s):  
Antonio Macchia ◽  
Valentina Dafnae Cuomo ◽  
Antonia Di Mola ◽  
Giovanni Pierri ◽  
Consiglia Tedesco ◽  
...  
Keyword(s):  
One Pot ◽  
Michael Reactions

Direct synthesis of defective ultrathin brookite-phase TiO2 nanosheets showing flexible electronic band states

2021 ◽  
Author(s):  
Weixin Zhao ◽  
Shenqian Ma ◽  
Jun Zhou ◽  
Guolei Xiang
Keyword(s):  
Direct Synthesis ◽  
One Pot ◽  
Electronic Band ◽  
Flexible Electronic ◽  
Tio2 Nanosheets ◽  
Brookite Phase ◽  
Thin Nanosheets

A one-pot protocol to directly prepare atomically-thin nanosheets of brookite-phase TiO2 is developed by hydrolyzing TiCl3 in formamide.

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