Palladium-catalyzed synthesis of 2-alkenyl-3-arylindoles via a dual α-arylation strategy: formal synthesis of the antilipemic drug fluvastatin

2015 ◽  
Vol 13 (45) ◽  
pp. 10995-11002 ◽  
Author(s):  
Ajit Prabhakar Kale ◽  
Gangam Srikanth Kumar ◽  
Manmohan Kapur

A new approach has been developed for the synthesis of substituted 2-alkenyl-3-arylindoles utilizing a palladium-catalyzed dual α-arylation of TES-enol ethers of enones as the key step.

2014 ◽  
Vol 12 (46) ◽  
pp. 9333-9336 ◽  
Author(s):  
Yamu Xia ◽  
Ying Xia ◽  
Yan Zhang ◽  
Jianbo Wang

2012 ◽  
Vol 55 (6) ◽  
pp. 1097-1100 ◽  
Author(s):  
Rui Ding ◽  
YunYu Lu ◽  
HeQuan Yao ◽  
BingFeng Sun ◽  
GuoQiang Lin

ChemInform ◽  
2013 ◽  
Vol 44 (40) ◽  
pp. no-no
Author(s):  
Jing Zeng ◽  
Jimei Ma ◽  
Shaohua Xiang ◽  
Shuting Cai ◽  
Xue-Wei Liu

ChemInform ◽  
2010 ◽  
Vol 27 (15) ◽  
pp. no-no
Author(s):  
T. MINAMI ◽  
A. NISHIMOTO ◽  
M. HANAOKA

Synthesis ◽  
2021 ◽  
Author(s):  
Zhuo Zeng ◽  
Zhanyu He ◽  
Chu Yan ◽  
Mei Zhang ◽  
Majeed Irfan ◽  
...  

AbstractPalladium-catalyzed Hiyama coupling of active thioureas via selective C–N bond cleavage is reported. Notably, the new approach employed active thioureas as coupling partners in the presence of arylsilanes to give amides in good yield. Further, this strategy, which utilized CuF2 as a key oxidant and activator, afforded various amide products under mild conditions and an easy to handle procedure without extra base.


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