The first proton sponge-based amino acids: synthesis, acid–base properties and some reactivity

2015 ◽  
Vol 13 (31) ◽  
pp. 8524-8532 ◽  
Author(s):  
Valery A. Ozeryanskii ◽  
Anastasia Yu. Gorbacheva ◽  
Alexander F. Pozharskii ◽  
Marina P. Vlasenko ◽  
Alexander Yu. Tereznikov ◽  
...  
Keyword(s):  
Amino Acids ◽  
Proton Sponge ◽  
Acid Base ◽  
Base Properties

The first hybrid bases constructed from 1,8-bis(dimethylamino)naphthalene and glycine or alanine residues were synthesised and structurally characterised and unusual channels of their reactivity revealed.

Modeling solubility and acid-base properties of some polar side chain amino acids in NaCl and (CH 3 ) 4 NCl aqueous solutions at different ionic strengths and temperatures

2018 ◽  
Vol 459 ◽  
pp. 51-64 ◽  
Author(s):  
Clemente Bretti ◽  
Rosalia Maria Cigala ◽  
Ottavia Giuffrè ◽  
Gabriele Lando ◽  
Silvio Sammartano
Keyword(s):  
Amino Acids ◽  
Aqueous Solutions ◽  
Side Chain ◽  
Acid Base ◽  
Base Properties

scholarly journals Self-Structuring in Water of Polyamidoamino Acids with Hydrophobic Side Chains Deriving from Natural α-Amino Acids

Polymers ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1261 ◽  
Author(s):  
Federica Lazzari ◽  
Amedea Manfredi ◽  
Jenny Alongi ◽  
Raniero Mendichi ◽  
Fabio Ganazzoli ◽  
...  
Keyword(s):  
Amino Acids ◽  
Main Chain ◽  
Intramolecular Interactions ◽  
Wavelength Interval ◽  
Acid Base ◽  
Repeat Units ◽  
Inflection Points ◽  
Ph Dependent ◽  
Selective Interactions ◽  
Base Properties

This paper reports on synthesis, acid-base properties and self-structuring in water of chiral polyamidoamino acids (PAACs) obtained by polyaddition of N,N′-methylenebisacrylamide with l-alanine, l-valine and l-leucine (M-l-Ala, M-l-Val, M-l-Leu) with potential for selective interactions with biomolecules. The polymers maintained the acid-base properties of amino acids. In water, the circular dichroism spectra of PAACs revealed pH-dependent structuring in the range 3–11 and in the wavelength interval 200–280 nm. Taking as reference the values at pH 3, the differential molar ellipticities were plotted in the pH interval 3–11. Sigmoidal curves were obtained presenting inflection points at pH 8.1, 6.8 and 7.3 for M-l-Ala, M-l-Val and M-l-Leu, respectively, corresponding to the amine half-ionization. Theoretical modeling showed that PAACs assumed stable folded conformations. Intramolecular interactions led to transoid arrangements of the main chain reminiscent of protein hairpin motif. Oligomers with ten repeat units had simulated gyration radii consistent with the hydrodynamic radii obtained by dynamic light scattering.

Synthesis and acid-base properties of aminophosphine oxides on the basis of natural amino acids

2012 ◽  
Vol 82 (8) ◽  
pp. 1453-1454 ◽  
Author(s):  
R. A. Cherkasov ◽  
A. R. Garifzyanov ◽  
S. A. Koshkin ◽  
N. V. Davletshina
Keyword(s):  
Amino Acids ◽  
Acid Base ◽  
Natural Amino Acids ◽  
Base Properties
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