Heterocycles from methylenecyclopropanes

2015 ◽  
Vol 13 (31) ◽  
pp. 8379-8392 ◽  
Author(s):  
Lei Yu ◽  
Mingxuan Liu ◽  
Fenglin Chen ◽  
Qing Xu
Keyword(s):  
Organic Synthesis ◽  
Organic Reactions ◽  
The Novel

The construction of heterocycles from MCPs affords more opportunities for the quick synthesis of elaborately substituted products. This review aims to summarize the novel organic reactions of MCPs to produce heterocycles published in recent years, which have provided specific and powerful tools for organic synthesis.

The molecular diversity of 1,8-diaminonaphthalene in organic chemistry

2020 ◽  
Vol 23 ◽  
Author(s):  
Ghodsi Mohammadi Ziarani ◽  
Fatemeh Mohajer ◽  
Suraj N. Mali
Keyword(s):  
Organic Chemistry ◽  
Organic Synthesis ◽  
Molecular Diversity ◽  
Organic Reactions ◽  
Recent Application ◽  
Organic Structure

: 1,8-diaminonaphthalene (1,8-DAN) with special organic structure was applied in organic synthesis to provide efficient complex scaffolds, through the two or four-component fashion. This review highlights its recent application in organic reactions under different conditions and heterogynous catalysts to produce various molecules, which were used as medicines, sensors, and dyes.

scholarly journals An integrated console for capsule-based, automated organic synthesis

2021 ◽  
Author(s):  
Tuo Jiang ◽  
Samuele Bordi ◽  
Angus E. McMillan ◽  
Kuang-Yen Chen ◽  
Fumito Saito ◽  
...  
Keyword(s):  
Operating System ◽  
Organic Synthesis ◽  
User Involvement ◽  
Organic Reactions ◽  
Complex Organic

Using a combination of reagent design, hardware engineering, and a simple operating system we provide an instrument capable of executing complex organic reactions using prepacked capsules with minimal user involvement.

The Molecular Diversity Scope of Oxindole derivatives in Organic Synthesis.

2021 ◽  
Vol 25 ◽  
Author(s):  
Ghodsi Mohammadi Ziarani ◽  
Fatemeh Javadi ◽  
Fatemeh Mohajer
Keyword(s):  
Organic Chemistry ◽  
Organic Synthesis ◽  
Molecular Diversity ◽  
Biological Properties ◽  
Organic Reactions ◽  
Microbial Properties ◽  
Anti Cancer

: The role of oxindole derivatives is discussed as starting materials in diverse organic reactions including two and more components between the years 2014 until 2020. Oxindoles are famous because of their biological properties for instance chromanone-fused polycyclic pyrrolidinyl-dispirooxindoles, functionalized polycyclic spiro-fused carbocyclicoxindole, and 3,3-disubstituted oxindoles have anti-cancer, anti-tumor, and anti-microbial properties, respectively. Therefore, various methods for synthesizing the oxindole structures have received more attention in organic chemistry.

USE OF FACTORIAL DESIGN IN OPTIMIZATION OF MICROWAVE ASSISTED ORGANIC SYNTHESIS OF SOME AZOLES

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (10) ◽  
pp. 24-33
Author(s):  
R. R Somani ◽  
◽  
G. J. Sanap ◽  
P. K Chaskar
Keyword(s):  
Factorial Design ◽  
Organic Synthesis ◽  
Maximum Yield ◽  
Minimum Time ◽  
Organic Reactions ◽  
Design Approach ◽  
Environment Friendly ◽  
Microwave Assisted ◽  
Synthetic Reactions ◽  
32 Factorial Design

In the era of environment friendly chemistry, Microwave Assisted Organic Synthesis (MAOS) has proved to be an effective tool to achieve maximum yield in minimum time without compromising on quality. The present work focuses on synthesis of some bioactive heterocyclic azoles using MAOS. However, the synthetic reactions are optimized using a known technique of factorial designing. Here, 32 factorial design approach is used to achieve the set targets of yields and purity. The outcome has been very promising and opens up new avenues for organic chemists who face challenges in optimizing organic reactions.

Tin-Mediated Radical Cyclization Reactions

2021 ◽  
Vol 25 ◽  
Author(s):  
Saima malik ◽  
Aditya G. Lavekar ◽  
Bimal Krishna Banik
Keyword(s):  
Organic Compounds ◽  
Organic Synthesis ◽  
Biological Significance ◽  
Radical Cyclization ◽  
Organic Reactions ◽  
Cyclization Reactions ◽  
Complex Molecules ◽  
Radical Chemistry ◽  
Wide Range

: The radical was first come into existence in 1900 by Gomberg, where the triphenylmethane radical was explored. Thus, even to date, two centuries have seen radical chemistry as the methodology of preference in organic synthesis. Due to the fascinating nature of the radical-mediated cyclization reactions, it always caught the eye of organic chemists for the synthesis of novel organic compounds with diverse stereochemistry. Moreover, the development of radical methods further proves beneficial for the synthesis by providing atom- and step-economical methods to complex molecules. Among these, where radical chemistry has been employed, the use of tin-based radical annulation is the most common and widely used field for the synthesis of a wide range of organic reactions with medicinal importance. In this review, we compiled recent tin-mediated radical cyclization reactions toward the synthesis of molecules of biological significance.

Organosilicon-Mediated Organic Synthesis (SiMOS): A Personal Account

Synlett ◽  
2019 ◽  
Vol 31 (01) ◽  
pp. 21-34 ◽  
Author(s):  
Li Li ◽  
Yun-Long Wei ◽  
Li-Wen Xu
Keyword(s):  
Organic Synthesis ◽  
Organic Reactions ◽  
Personal Account ◽  
Allylic Silanes ◽  
Alternative Procedures

The organosilicon-mediated organic synthesis (SiMOS) has attracted much attention over the recent decades. However, the use of organosilicon reagents with novel catalytic strategies remains to be explored. This Account summarizes our group’s progress mainly based on the application of a wide variety of organosilicon reagents, including allylic silanes, trifluoromethyl silane, acylsilanes, chlorosilanes, hydrosilanes, trimethylsilyldiazomethane, trimethylsiloxyfuran, silanols, α-trimethylsilylmethylacetate, and trimethylsilylcyanide, in catalysis and organic reactions. These transformations were proved to be alternative procedures for the construction of structurally diverse compounds.1 Introduction2 The Exploration of New Reactivity of Organosilicon Reagent in Organic Synthesis2.1 Allylic Silanes2.2 Trifluomethylsilane (TMSCF3)2.3 Acylsilanes2.4 Chlorosilanes and Hydrosilanes2.5 Trimethylsilyldiazomethane (TMSD)2.6 Trimethylsiloxyfuran2.7 Silanols2.8 Trimethylsilylcyanide (TMSCN)3 Conclusion and Perspective

scholarly journals Zeolites Catalyze the Nazarov Reaction and the tert-Butylation of Alcohols by Stabilization of Carboxonium Intermediates

Synthesis ◽  
2020 ◽  
Vol 52 (14) ◽  
pp. 2031-2037
Author(s):  
Antonio Leyva-Pérez ◽  
María Tejeda-Serrano ◽  
Sergio Sanz-Navarro ◽  
Finn Blake
Keyword(s):  
Organic Synthesis ◽  
Butyl Acetate ◽  
Strong Acid ◽  
Organic Reactions ◽  
High Yield ◽  
Acid Catalysts ◽  
Nazarov Cyclization ◽  
Triflic Acid ◽  
Nazarov Reaction ◽  
Tert Butyl

Zeolites are the most used catalysts worldwide in petrochemistry processes, with particular ability to stabilize carbocations. However, the use of zeolites in organic synthesis is still scarce. We show here that representative carboxonium-mediated organic reactions, such as the Nazarov cyclization and the tert-butylation of alcohols with tert-butyl acetate, typically performed with very strong acid catalysts in solution such as triflic acid, can be catalyzed by simple zeolites with high yield and selectivity. The aluminosilicate framework stabilizes the intermediate carboxonium species and overrides the need for superacid protons in solution.

scholarly journals Organic synthesis by Twin Screw Extrusion (TSE): continuous, scalable and solvent-free

2017 ◽  
Vol 19 (6) ◽  
pp. 1507-1518 ◽  
Author(s):  
Deborah E. Crawford ◽  
Clodagh K. G. Miskimmin ◽  
Ahmad B. Albadarin ◽  
Gavin Walker ◽  
Stuart L. James
Keyword(s):  
Organic Synthesis ◽  
Solvent Free ◽  
Pure Form ◽  
Organic Reactions ◽  
Twin Screw Extrusion ◽  
Continuous Basis ◽  
Screw Extrusion ◽  
Twin Screw ◽  
Work Up

Several organic reactions have been achieved quantitatively without any added solvent, using solid or liquid reagents, on a continuous basis; products are typically obtained directly in analytically pure form, requiring no work-up.

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