Evaluation of the antibacterial and antibiofilm activities of novel CRAMP–vancomycin conjugates with diverse linkers

2015 ◽  
Vol 13 (27) ◽  
pp. 7477-7486 ◽  
Author(s):  
Nigam M. Mishra ◽  
Yves Briers ◽  
Chris Lamberigts ◽  
Hans Steenackers ◽  
Stijn Robijns ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Click Chemistry

Conjugates of CRAMP (cathelicidin-related antimicrobial peptides) and vancomycin were synthesised using click chemistry with diverse hydrophilic and hydrophobic linkers.

Convenient Preparation of Bactericidal Hydrogels by Covalent Attachment of Stabilized Antimicrobial Peptides Using Thiol–ene Click Chemistry

2014 ◽  
Vol 3 (5) ◽  
pp. 477-480 ◽  
Author(s):  
Rik T. C. Cleophas ◽  
Martijn Riool ◽  
H. (Linda) C. Quarles van Ufford ◽  
Sebastian A. J. Zaat ◽  
John A. W. Kruijtzer ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Click Chemistry ◽  
Covalent Attachment ◽  
Convenient Preparation

Antimicrobial peptides in COPD

Pneumologie ◽  
2009 ◽  
Vol 63 (S 01) ◽  
Author(s):  
G Günther ◽  
E Andresen ◽  
J Bullwinkel ◽  
C Lange ◽  
H Heine
Keyword(s):  
Antimicrobial Peptides

Click Chemistry Expedited Radiosynthesis: Sulfur [18F]fluoride Exchange of Aryl Fluorosulfates

2019 ◽  
Author(s):  
Qinheng Zheng ◽  
Hongtao Xu ◽  
Hua Wang ◽  
Wen-Ge Han Du ◽  
Nan Wang ◽  
...  
Keyword(s):  
Click Chemistry ◽  
High Performance ◽  
Isotopic Exchange ◽  
Tumor Imaging ◽  
Radiochemical Yield ◽  
Exchange Method ◽  
Molar Activity ◽  
Positron Emission ◽  
Sulfur Fluoride

The lack of simple, efficient [<sup>18</sup>F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [<sup>18</sup>F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated <sup>18</sup>F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol<sup>–1</sup>) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [<sup>18</sup>F]fluorosulfate is demonstrated by the <i>in vivo</i> tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

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