Copper catalysed direct amidation of methyl groups with N–H bonds

2015 ◽  
Vol 13 (26) ◽  
pp. 7289-7293 ◽  
Author(s):  
Yao Huang ◽  
Tieqiao Chen ◽  
Qiang Li ◽  
Yongbo Zhou ◽  
Shuang-Feng Yin
Keyword(s):  
Functional Groups ◽  
Methyl Groups ◽  
Straightforward Method ◽  
Oxidative Amidation ◽  
Tertiary Amides ◽  
Direct Amidation

An efficient copper catalysed direct aerobic oxidative amidation of methyl groups of azaarylmethanes with N–H bonds producing amides is developed, which can produce primary, secondary and tertiary amides, including those with functional groups. This reaction represents a straightforward method for the preparation of amides from the readily available hydrocarbon starting materials.

Green synthesis of primary, secondary, and tertiary amides through oxidative amidation of methyl groups with amine hydrochlorides over recyclable CoFe2O4 NPs

RSC Advances ◽  
2016 ◽  
Vol 6 (108) ◽  
pp. 106873-106879 ◽  
Author(s):  
Esmaiel Eidi ◽  
Mohammad Zaman Kassaee
Keyword(s):  
Reaction Time ◽  
Green Synthesis ◽  
High Yield ◽  
Methyl Groups ◽  
Short Reaction Time ◽  
Oxidative Amidation ◽  
Tertiary Amides ◽  
Operational Simplicity ◽  
Amine Hydrochlorides

This protocol provides high yield, short reaction time, and operational simplicity, green and low cast procedure for the synthesis of all types of amides.

Direct amidation of acid fluorides using germanium amides

2021 ◽  
Author(s):  
Ardalan Hayatifar ◽  
Emily Elifritz ◽  
Molly Bloom ◽  
Kaitlyn Pixley ◽  
Chris Fennell ◽  
...  
Keyword(s):  
Functional Groups ◽  
New Method ◽  
New Methods ◽  
Acid Fluorides ◽  
Direct Amidation

Amide functional groups are an essential linkage that are found in peptides, proteins, and pharmaceuticals and new methods are constantly being sought for their formation. Here, a new method is...

Parallel synthesis of meso-substituted corroles and meso-substituted [22]pentaphyrins(1.1.1.0.0) from diacyl-dipyrromethanes

2003 ◽  
Vol 07 (04) ◽  
pp. 239-248 ◽  
Author(s):  
Daniel T. Gryko ◽  
Mariusz Tasior ◽  
Beata Koszarna
Keyword(s):  
Functional Groups ◽  
Parallel Synthesis ◽  
New Method ◽  
Large Excess ◽  
Tertiary Amides ◽  
Moderate Yield ◽  
Made In

A new method was devised for the synthesis of 1,9-diacyldipyrromethanes - crucial intermediates in the synthesis of meso-substituted corroles and porphyrins with different substituents. The diacylodipyrromethanes formation involves acylation of dipyrromethanes with salts made in situ from POCl 3 and tertiary amides. This modified Vilsmeier approach gives higher yields and no concomitant formation of monoacyldipyrromethanes as compared with the Grignard route. Moreover, compounds possessing groups previously inaccessible ( CN , NO 2 etc.) can be synthesized. During optimization of the transformation of diacyldipyrromethanes into meso-substituted corroles it was found that if macrocyclization reaction mediated by DDQ is performed in the presence of large excess of pyrrole, meso-substituted [22]pentaphyrins(1.1.1.0.0) can be obtained in moderate yield. The currently described procedure constitutes a new method for the synthesis of these valuable porphyrinoids. Corroles possessing interesting, easy to transform, functional groups were obtained in 3-40% yield.

The copper-catalyzed aerobic oxidative amidation of tertiary amines

2015 ◽  
Vol 51 (99) ◽  
pp. 17596-17599 ◽  
Author(s):  
Hui-Cheng Cheng ◽  
Wen-Jun Hou ◽  
Zeng-Wen Li ◽  
Ming-Yu Liu ◽  
Bing-Tao Guan
Keyword(s):  
Efficient Method ◽  
Tertiary Amines ◽  
Oxidative Amidation ◽  
Tertiary Amides

A general and efficient method for the synthesis of tertiary amides has been developed via the copper-catalyzed aerobic oxidative amidation of tertiary amines.

scholarly journals Chemical functionality at the liquid surface of pure unsaturated fatty acids

2021 ◽  
Author(s):  
Aisling C. Stewart ◽  
Martin J. Paterson ◽  
Stuart J. Greaves
Keyword(s):  
Molecular Dynamics ◽  
Fatty Acids ◽  
Functional Groups ◽  
Unsaturated Fatty Acids ◽  
Liquid Surface ◽  
Methyl Groups ◽  
Chemical Functionality

Molecular dynamics reveals the surface preference of functional groups at the liquid surface of fatty acids is unlike the bulk. Methyl groups disproportionally dominate while acid groups have minimal presence, CC increases linearly only up to n = 3.

Copper-Catalyzed Oxidative Amidation of Aldehydes with Amine Salts: Synthesis of Primary, Secondary, and Tertiary Amides

2012 ◽  
Vol 77 (18) ◽  
pp. 8007-8015 ◽  
Author(s):  
Subhash Chandra Ghosh ◽  
Joyce S. Y. Ngiam ◽  
Abdul M. Seayad ◽  
Dang Thanh Tuan ◽  
Christina L. L. Chai ◽  
...  
Keyword(s):  
Oxidative Amidation ◽  
Tertiary Amides ◽  
Amine Salts

Potentiometric titration as a straightforward method to assess the number of functional groups on shortened carbon nanotubes

Carbon ◽  
2010 ◽  
Vol 48 (9) ◽  
pp. 2447-2454 ◽  
Author(s):  
Cristian Samorì ◽  
Raquel Sainz ◽  
Cécilia Ménard-Moyon ◽  
Francesca M. Toma ◽  
Enrica Venturelli ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Potentiometric Titration ◽  
Functional Groups ◽  
Straightforward Method

ChemInform Abstract: Copper Catalyzed Direct Amidation of Methyl Groups with N-H Bonds.

ChemInform ◽  
2015 ◽  
Vol 46 (44) ◽  
pp. no-no
Author(s):  
Yao Huang ◽  
Tieqiao Chen ◽  
Qiang Li ◽  
Yongbo Zhou ◽  
Shuang-Feng Yin
Keyword(s):  
Methyl Groups ◽  
Direct Amidation
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