Improvement of the immune efficacy of carbohydrate vaccines by chemical modification on the GM3 antigen

2015 ◽  
Vol 13 (22) ◽  
pp. 6399-6406 ◽  
Author(s):  
Xiu-Jing Zheng ◽  
Fan Yang ◽  
Mingwei Zheng ◽  
Chang-Xin Huo ◽  
Ye Zhang ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Engineering Technology ◽  
Immune Efficacy ◽  
Carbohydrate Vaccines ◽  
Metabolic Oligosaccharide Engineering ◽  
Gm3 Antigen

N-modified GM3 glycoconjugates improved the efficiency of the vaccination without the combination of metabolic oligosaccharide engineering technology.

scholarly journals Chemical reporters to study mammalian O-glycosylation

2021 ◽  
Author(s):  
Kathryn E. Huxley ◽  
Lianne I. Willems
Keyword(s):  
Chemical Modification ◽  
Living Cells ◽  
Biosynthetic Pathways ◽  
Dynamic Nature ◽  
Dynamic Changes ◽  
Cellular Processes ◽  
Chemical Reporter ◽  
Native Context ◽  
Normal Cellular Function ◽  
Metabolic Oligosaccharide Engineering

Glycans play essential roles in a range of cellular processes and have been shown to contribute to various pathologies. The diversity and dynamic nature of glycan structures and the complexities of glycan biosynthetic pathways make it challenging to study the roles of specific glycans in normal cellular function and disease. Chemical reporters have emerged as powerful tools to characterise glycan structures and monitor dynamic changes in glycan levels in a native context. A variety of tags can be introduced onto specific monosaccharides via the chemical modification of endogenous glycan structures or by metabolic or enzymatic incorporation of unnatural monosaccharides into cellular glycans. These chemical reporter strategies offer unique opportunities to study and manipulate glycan functions in living cells or whole organisms. In this review, we discuss recent advances in metabolic oligosaccharide engineering and chemoenzymatic glycan labelling, focusing on their application to the study of mammalian O-linked glycans. We describe current barriers to achieving glycan labelling specificity and highlight innovations that have started to pave the way to overcome these challenges.

Measuring engineering technology education quality from students' perspective

2012 ◽  
Author(s):  
Nurul Na'imy Wan ◽  
Norzalina Othman ◽  
Mohd Fauzi Zainol Abidin ◽  
Mazwin Tan ◽  
Azhar Aziz
Keyword(s):  
Technology Education ◽  
Education Quality ◽  
Engineering Technology

Photoconductivity in Vacuum Deposited Films of Silicon-Based Polymers

1996 ◽  
Vol 444 ◽  
Author(s):  
H. Okumoto ◽  
M. Shimomura ◽  
N. Minami ◽  
Y. Tanabe
Keyword(s):  
Charge Transfer ◽  
Chemical Modification ◽  
Electronic Transport ◽  
Hole Transport ◽  
Electron Acceptors ◽  
Oxygen Atmosphere ◽  
Dangling Bonds ◽  
Silicon Based ◽  
Deposited Films

AbstractSilicon-based polymers with σconjugated electrons have specific properties; photoreactivity for microlithography and photoconductivity for hole transport materials. To explore the possibility of combining these two properties to develop photoresists with electronic transport capability, photoconductivity of polysilanes is investigated in connection with their photoinduced chemical modification. Increase in photocurrent is observed accompanying photoreaction of poly(dimethylsilane) vacuum deposited films. This increase is found to be greatly enhanced in oxygen atmosphere. Such changes of photocurrent can be explained by charge transfer to electron acceptors from Si dangling bonds postulated to be formed during photoreaction.

On the issue of the revitalization and modernization of the engineering in Russia

2019 ◽  
pp. 19-24
Author(s):  
A. E. Melnikov
Keyword(s):  
National Economy ◽  
Technological Progress ◽  
Developed Countries ◽  
The State ◽  
Engineering Technology ◽  
Operational Characteristics ◽  
Technical Potential ◽  
Significant Barrier ◽  
The Developed Countries ◽  
Competitive Products

Currently, one of the important tasks of the economic policy of Russia is the formation of a hightech image of the national economy, capable of effective functioning in the changing global geopolitical and geoeconomic conditions. In this context, the issue of revitalization of mechanical engineering, which plays a key role in the development of the country’s economy, is of particular relevance. This sector is a link between scientific and technological progress and the level of provision of domestic producers with domestic machines and equipment, allowing them to produce competitive products and to a lesser extent depend on the state of the external environment. The example of the developed countries of the world shows that the development of advanced engineering technology significantly increases the efficiency of the national economy, helps to accelerate its growth. At the same time, in Russia, in order to unleash the scientific and technical potential and activate engineering, it is necessary to initiate modernization processes in it. Based on the foregoing, the purpose of the study is to analyze the state of Russian engineering from the position of its role in the country’s economy. It is shown that at present a significant barrier to the development of this sector is the predominance of imported equipment, due to technical and operational characteristics, often superior to domestic counterparts.

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