Discovery of 4-acetyl-3-(4-fluorophenyl)-1-(p-tolyl)-5-methylpyrrole as a dual inhibitor of human P-glycoprotein and Staphylococcus aureus Nor A efflux pump

2015 ◽  
Vol 13 (19) ◽  
pp. 5424-5431 ◽  
Author(s):  
Jaideep B. Bharate ◽  
Samsher Singh ◽  
Abubakar Wani ◽  
Sadhana Sharma ◽  
Prashant Joshi ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Efflux Pump ◽  
Dual Inhibitor ◽  
P Glycoprotein ◽  
Dual Inhibition ◽  
And Staphylococcus Aureus

Pyrroles showed dual inhibition of human P-gp and S. aureus Nor A efflux pump.

scholarly journals Dual Inhibitor of MurD and MurE Ligases from Escherichia coli and Staphylococcus aureus

2012 ◽  
Vol 3 (8) ◽  
pp. 626-630 ◽  
Author(s):  
Tihomir Tomašić ◽  
Roman Šink ◽  
Nace Zidar ◽  
Anja Fic ◽  
Carlos Contreras-Martel ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Dual Inhibitor ◽  
And Staphylococcus Aureus

3-(Benzo[d][1,3]dioxol-5-ylamino)-N-(4-fluorophenyl)thiophene-2-carboxamide overcomes cancer chemoresistance via inhibition of angiogenesis and P-glycoprotein efflux pump activity

2015 ◽  
Vol 13 (14) ◽  
pp. 4296-4309 ◽  
Author(s):  
Ramesh Mudududdla ◽  
Santosh K. Guru ◽  
Abubakar Wani ◽  
Sadhana Sharma ◽  
Prashant Joshi ◽  
...  
Keyword(s):  
Efflux Pump ◽  
Efflux Pumps ◽  
P Glycoprotein ◽  
Pump Activity ◽  
Inhibition Of Angiogenesis ◽  
Dual Inhibition ◽  
Cancer Chemoresistance

Thiophene-2-carboxamides displayed dual inhibition of angiogenesis and P-gp efflux pumps.

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