scholarly journals Binding-induced, turn-on fluorescence of the EGFR/ERBB kinase inhibitor, lapatinib

2015 ◽  
Vol 13 (17) ◽  
pp. 5006-5011 ◽  
Author(s):  
James N. Wilson ◽  
Wenjun Liu ◽  
Adrienne S. Brown ◽  
Ralf Landgraf
Keyword(s):  
Fluorescence Imaging ◽  
Cellular Uptake ◽  
Kinase Inhibitor ◽  
Photophysical Properties ◽  
Turn On

The photophysical properties, fluorescence imaging, cellular uptake and distribution of lapatinib, an EGFR/ERBB inhibitor are reported.

Ubiquinone-BODIPY nanoparticles for tumor redox-responsive fluorescence imaging and photodynamic activity

2021 ◽  
Author(s):  
Byunghee Hwang ◽  
Tae-Il Kim ◽  
Hyunjin Kim ◽  
Sungjin Jeon ◽  
Yongdoo Choi ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Selective Activation ◽  
Turn On ◽  
Intracellular Environment ◽  
Redox Responsive ◽  
Photodynamic Activity

A ubiquinone-BODIPY photosensitizer self-assembles into nanoparticles (PS-Q-NPs) and undergoes selective activation within the highly reductive intracellular environment of tumors, resulting in “turn-on” fluorescence and photosensitizing activities.

scholarly journals A New Fluorescence Probe for Rapid Detection of Amyloid

2018 ◽  
Author(s):  
Nidhi Gour ◽  
Vivek Shinh Kshtriya ◽  
Bharti Koshti ◽  
Shradhey Gupta ◽  
khashti Ballabh Joshi ◽  
...  
Keyword(s):  
Rapid Detection ◽  
Control Experiment ◽  
Fluorescence Probe ◽  
Photophysical Properties ◽  
Cost Effective ◽  
The Novel ◽  
High Quantum Yield ◽  
Turn On ◽  
Heat Treated ◽  
Amyloidogenic Peptides

<p>We report efficient synthesis and photophysical properties of a novel fluorescent pyridothiazole based construct by a facile methodology and its application as a sensor for rapid, selective as well as sensitive detection of amyloid fibres. The novel compound has exceptionally high quantum yield and sensitivity. The fluorescence of pyridothiazole construct is completely quenched (Turn-OFF) upon addition of cupric ions and the fluorescence is recovered on addition of amyloidogenic peptides like A<i>β</i><sub>42 </sub>(Turn-ON). The control experiment with native and heat treated BSA suggest that the new probe binds to beeta/<i>β</i> sheets present in amyloid. The new probe offers direct visualization of fluorescence ‘Turn-OFF’ ‘Turn-ON’ under long UV without the use of sophisticated instrumentation. Hence, a very simple, facile and cost-effective methodology for the rapid detection of amyloid is presented and it may in all possibility pave the way for the design of a better probe for sensing amyloids than conventional ThT.</p>

scholarly journals Cu-Based Turn-on Fluorescent Sensors for Cu-rich Amyloid β Aggregates

2021 ◽  
Author(s):  
Yiran Huang ◽  
Liang Sun ◽  
Liviu M. Mirica
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Fluorescence Imaging ◽  
Protein Misfolding ◽  
Picolinic Acid ◽  
Amyloid Β ◽  
Fluorescent Sensors ◽  
Aβ Oligomers ◽  
Turn On ◽  
Aβ Aggregation

<div>Protein misfolding and metal dishomeostasis are two key</div><div>pathological factors of Alzheimer’s disease. Previous studies have showed that Cu‐mediated Aβ aggregation pathways lead to formation of neurotoxic Aβ oligomers. Herein, we reported a series of picolinic acid‐based Cu‐activatable sensors, which can be used for the fluorescence imaging of Cu‐rich Aβ aggregates.</div>

Disulfide bond-based self-crosslinked carbon-dots for turn-on fluorescence imaging of GSH in living cells

The Analyst ◽  
2020 ◽  
Vol 145 (8) ◽  
pp. 2982-2987 ◽  
Author(s):  
Jia Li ◽  
Yuhui Wang ◽  
Shan Sun ◽  
A-Man Lv ◽  
Kai Jiang ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Disulfide Bond ◽  
Carbon Dots ◽  
Living Cells ◽  
Turn On

A self-quenched nanoprobe built on a disulfide bond-based crosslink of carbon-dots has been constructed for intracellular GSH sensing.

scholarly journals A glutathione responsive pyrrolopyrrolidone nanotheranostic agent for turn-on fluorescence imaging guided photothermal/photodynamic cancer therapy

2019 ◽  
Vol 3 (10) ◽  
pp. 2143-2150 ◽  
Author(s):  
Jianhua Zou ◽  
Lei Xue ◽  
Nan Yang ◽  
Yanfang Ren ◽  
Zhe Fan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Fluorescence Imaging ◽  
Therapeutic Efficacy ◽  
Turn On ◽  
Photodynamic Cancer Therapy

Herein, GSH responsive pyrrolopyrrolidone derivatives with enhanced photodynamic/photothermal therapeutic efficacy were designed, which can be used as colorimetric probes.

A fluorescent probe for the discrimination between Cys and GSH

2015 ◽  
Vol 7 (24) ◽  
pp. 10371-10375 ◽  
Author(s):  
Lun Song ◽  
Qian Sun ◽  
Nan Wang ◽  
Zhaoyang Chen ◽  
Weibing Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Fluorescence Imaging ◽  
Turn On ◽  
Spectral Channels

A turn-on fluorescent probe was designed and synthesized for discriminating between Cys and GSH from different spectral channels. The probe has potential in fluorescence imaging of cellular Cys.

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