Synthesis of new generation triazolyl- and isoxazolyl-containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: in vitro, structure–activity relationship, pharmacokinetics and in vivo evaluation

Gurunadham Munagala; Kushalava Reddy Yempalla; Samsher Singh; Sumit Sharma; Nitin Pal Kalia; Vikrant Singh Rajput; Sunil Kumar; Sanghapal D. Sawant; Inshad Ali Khan; Ram A. Vishwakarma; Parvinder Pal Singh

doi:10.1039/c5ob00054h

Synthesis of new generation triazolyl- and isoxazolyl-containing 6-nitro-2,3-dihydroimidazooxazoles as anti-TB agents: in vitro, structure–activity relationship, pharmacokinetics and in vivo evaluation

Organic & Biomolecular Chemistry ◽

10.1039/c5ob00054h ◽

2015 ◽

Vol 13 (12) ◽

pp. 3610-3624 ◽

Cited By ~ 14

Author(s):

Gurunadham Munagala ◽

Kushalava Reddy Yempalla ◽

Samsher Singh ◽

Sumit Sharma ◽

Nitin Pal Kalia ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

In Vivo Evaluation ◽

Structure Activity ◽

New Generation

Promising nitroimidazoloxazole scaffold gives another novel triazolyl-containing 6-nitro-2,3-dihydroimidazooxazole as anti-TB lead.

Download Full-text

Structure–Activity Relationship and in Vitro and in Vivo Evaluation of the Potent Cytotoxic Anti-microtubule AgentN-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium Chloride and Its Analogues As Antitumor Agents

Journal of Medicinal Chemistry ◽

10.1021/jm400639z ◽

2013 ◽

Vol 56 (17) ◽

pp. 6829-6844 ◽

Cited By ~ 18

Author(s):

Aleem Gangjee ◽

Ying Zhao ◽

Sudhir Raghavan ◽

Cristina C. Rohena ◽

Susan L. Mooberry ◽

...

Keyword(s):

Antitumor Agents ◽

Structure Activity Relationship ◽

Activity Relationship ◽

In Vivo Evaluation ◽

Structure Activity

Download Full-text

Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2021.127923 ◽

2021 ◽

Vol 41 ◽

pp. 127923

Author(s):

Farhana Islam ◽

Tasdique M. Quadery ◽

Ruoli Bai ◽

Lerin R. Luckett-Chastain ◽

Ernest Hamel ◽

...

Keyword(s):

Antitumor Agents ◽

Structure Activity Relationship ◽

Activity Relationship ◽

In Vivo Evaluation ◽

Structure Activity ◽

Microtubule Targeting Agents

Download Full-text

Structure–activity relationship, in vitro and in vivo evaluation of novel dienyl sulphonyl fluorides as selective BuChE inhibitors for the treatment of Alzheimer's disease

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.1080/14756366.2021.1959571 ◽

2021 ◽

Vol 36 (1) ◽

pp. 1860-1873

Author(s):

Chengyao Wu ◽

Guijuan Zhang ◽

Zai-Wei Zhang ◽

Xia Jiang ◽

Ziwen Zhang ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Structure Activity Relationship ◽

Activity Relationship ◽

In Vivo Evaluation ◽

Structure Activity

Download Full-text

Linear Cationic Click Polymers/DNA Nanoparticles: In Vitro Structure–Activity Relationship and In Vivo Evaluation for Gene Delivery

Bioconjugate Chemistry ◽

10.1021/bc200008j ◽

2011 ◽

Vol 22 (6) ◽

pp. 1153-1161 ◽

Cited By ~ 15

Author(s):

Yu Gao ◽

Qi Yin ◽

Lingli Chen ◽

Zhiwen Zhang ◽

Yaping Li

Keyword(s):

Gene Delivery ◽

Structure Activity Relationship ◽

Activity Relationship ◽

In Vivo Evaluation ◽

Dna Nanoparticles ◽

Structure Activity

Download Full-text

STRUCTURE-ACTIVITY RELATIONSHIP OF VARIOUS ANALOGUES OF β-CORTICOTRROPHIN DETERMINED BY REFERENCE TO VARIOUS PARAMETERS IN VITRO AND IN VIVO

Acta Endocrinologica ◽

10.1530/acta.0.061s029 ◽

1969 ◽

Vol 61 (1_Suppl) ◽

pp. S29

Author(s):

Pierre A. Desaulles ◽

René Maier ◽

Matthys Staehelin

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

Download Full-text

The selective 5-HT2A receptor agonist 25CN-NBOH: Structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H]25CN-NBOH

Biochemical Pharmacology ◽

10.1016/j.bcp.2020.113979 ◽

2020 ◽

Vol 177 ◽

pp. 113979 ◽

Cited By ~ 3

Author(s):

Anders A. Jensen ◽

Adam L. Halberstadt ◽

Emil Märcher-Rørsted ◽

Anna U. Odland ◽

Muhammad Chatha ◽

...

Keyword(s):

Receptor Agonist ◽

Ex Vivo ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Binding Characteristics ◽

Structure Activity

Download Full-text

Fluoro-benzimidazole derivatives to cure Alzheimer’s disease: In-silico studies, synthesis, structure-activity relationship and in vivo evaluation for β secretase enzyme inhibition

Bioorganic Chemistry ◽

10.1016/j.bioorg.2019.102936 ◽

2019 ◽

Vol 88 ◽

pp. 102936 ◽

Cited By ~ 1

Author(s):

Sayyad Ali ◽

Muhammad Hassham Hassan Bin Asad ◽

Soham Maity ◽

Wahid Zada ◽

Albert A. Rizvanov ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Enzyme Inhibition ◽

In Silico ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Benzimidazole Derivatives ◽

In Vivo Evaluation ◽

Structure Activity ◽

In Silico Studies

Download Full-text

Radiochemical Investigations of99mTc−N3S-X-BBN[7−14]NH2: An in Vitro/in Vivo Structure−Activity Relationship Study Where X = 0-, 3-, 5-, 8-, and 11-Carbon Tethering Moieties

Bioconjugate Chemistry ◽

10.1021/bc020034r ◽

2003 ◽

Vol 14 (1) ◽

pp. 93-102 ◽

Cited By ~ 63

Author(s):

C. Jeffrey Smith ◽

Hariprasad Gali ◽

Gary L. Sieckman ◽

Chris Higginbotham ◽

Wynn A. Volkert ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Study

Download Full-text

Fungal metabolite ophiobolin A as a promising anti-glioma agent: In vivo evaluation, structure–activity relationship and unique pyrrolylation of primary amines

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2015.08.066 ◽

2015 ◽

Vol 25 (20) ◽

pp. 4544-4548 ◽

Cited By ~ 19

Author(s):

Ramesh Dasari ◽

Marco Masi ◽

Romana Lisy ◽

Marlène Ferdérin ◽

Lance R. English ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Primary Amines ◽

Fungal Metabolite ◽

In Vivo Evaluation ◽

Structure Activity

Download Full-text

Discovery and Structure−Activity Relationship of Antagonists of B-Cell Lymphoma 2 Family Proteins with Chemopotentiation Activity in Vitro and in Vivo

Journal of Medicinal Chemistry ◽

10.1021/jm050754u ◽

2006 ◽

Vol 49 (3) ◽

pp. 1165-1181 ◽

Cited By ~ 94

Author(s):

Michael D. Wendt ◽

Wang Shen ◽

Aaron Kunzer ◽

William J. McClellan ◽

Milan Bruncko ◽

...

Keyword(s):

B Cell ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

Download Full-text