The spacer arm length in cell-penetrating peptides influences chitosan/siRNA nanoparticle delivery for pulmonary inflammation treatment

Nanoscale ◽  
2015 ◽  
Vol 7 (47) ◽  
pp. 20095-20104 ◽  
Author(s):  
Eun Ju Jeong ◽  
Moonhwan Choi ◽  
Jangwook Lee ◽  
Taiyoun Rhim ◽  
Kuen Yong Lee
Keyword(s):  
Pulmonary Inflammation ◽  
Cell Penetrating Peptides ◽  
Nanoparticle Delivery ◽  
Cell Penetrating ◽  
Spacer Arm

scholarly journals Delivery of SiC-based nanoparticles into live cells driven by cell-penetrating peptides SAP and SAP-E

RSC Advances ◽  
2015 ◽  
Vol 5 (26) ◽  
pp. 20498-20502 ◽  
Author(s):  
T. Serdiuk ◽  
I. Bakanovich ◽  
V. Lysenko ◽  
S. A. Alekseev ◽  
V. A. Skryshevsky ◽  
...  
Keyword(s):  
Functional Groups ◽  
Cell Penetrating Peptides ◽  
Live Cells ◽  
Nanoparticle Delivery ◽  
Cell Penetrating ◽  
Covalent Conjugates

Cell-penetrating peptides enhance nanoparticle delivery into cells most efficiently if surface and peptide functional groups “match” to form non-covalent conjugates.

Oncolytic Coxsackievirus and the Mechanisms of its Effects on Cancer: A Narrative Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Ali Ahmadi ◽  
Hadi Esmaeili Gouvarchin Ghaleh ◽  
Ruhollah Dorostkar ◽  
Mahdieh Farzanehpour ◽  
Masoumeh Bolandian
Keyword(s):  
Genetic Disease ◽  
Control Cell ◽  
Gene Mutations ◽  
Therapeutic Agents ◽  
Cell Penetrating Peptides ◽  
Triggered Release ◽  
New Techniques ◽  
Viral Therapy ◽  
Cell Penetrating ◽  
Cancer Cell Targeting

Abstract:: Cancer is a genetic disease triggered by gene mutations, which control cell growth and their functionality inherited from previous generations. The targeted therapy of some tumors was not especially successful. A host of new techniques can be used to treat aptamer-mediated targeting, cancer immunotherapy, cancer stem cell (CSC) therapy, cell-penetrating peptides (CPPs), hormone therapy, intracellular cancer cell targeting, nanoparticles, and viral therapy. These include chemical-analog conjugation, gene delivery, ligand-receptor-based targeting, prodrug therapies, and triggered release strategies. Virotherapy is a biotechnological technique for turning viruses into therapeutic agents by the reprogramming of viruses to cure diseases. In several tumors, including melanoma, multiple myeloma, bladder cancer, and breast cancer, the oncolytic capacity of oncolytic Coxsackievirus has been studied. The present study aims to assess oncolytic Coxsackievirus and its mechanisms of effect on cancer cells.

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