RGD-functionalized ultrasmall iron oxide nanoparticles for targeted T1-weighted MR imaging of gliomas

Nanoscale ◽  
2015 ◽  
Vol 7 (34) ◽  
pp. 14538-14546 ◽  
Author(s):  
Yu Luo ◽  
Jia Yang ◽  
Yu Yan ◽  
Jingchao Li ◽  
Mingwu Shen ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Rgd Peptide ◽  
Oxide Nanoparticles

Ultrasmall Fe3O4 nanoparticles can be functionalized with an RGD peptide via a PEG spacer for targeted T1-weighted MR imaging of tumors.

Facile synthesis of RGD peptide-modified iron oxide nanoparticles with ultrahigh relaxivity for targeted MR imaging of tumors

2015 ◽  
Vol 3 (5) ◽  
pp. 721-732 ◽  
Author(s):  
Yong Hu ◽  
Jingchao Li ◽  
Jia Yang ◽  
Ping Wei ◽  
Yu Luo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Rgd Peptide ◽  
Oxide Nanoparticles ◽  
Facile Synthesis

RGD peptide-functionalized iron oxide nanoparticles with ultrahigh relaxivity can be synthesized for targeted MR imaging of αvβ3 integrin-overexpressing tumors.

scholarly journals Macrophage-Laden Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Enhanced Dual-Mode CT/MR Imaging of Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 995
Author(s):  
Yucheng Peng ◽  
Xiaomeng Wang ◽  
Yue Wang ◽  
Yue Gao ◽  
Rui Guo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Pamam Dendrimer ◽  
Great Promise ◽  
Oxide Nanoparticles ◽  
Dual Mode ◽  
Gold Nanoflowers ◽  
Average Size

The design of multimodal imaging nanoplatforms with improved tumor accumulation represents a major trend in the current development of precision nanomedicine. To this end, we report herein the preparation of macrophage (MA)-laden gold nanoflowers (NFs) embedded with ultrasmall iron oxide nanoparticles (USIO NPs) for enhanced dual-mode computed tomography (CT) and magnetic resonance (MR) imaging of tumors. In this work, generation 5 poly(amidoamine) (G5 PAMAM) dendrimer-stabilized gold (Au) NPs were conjugated with sodium citrate-stabilized USIO NPs to form hybrid seed particles for the subsequent growth of Au nanoflowers (NFs). Afterwards, the remaining terminal amines of dendrimers were acetylated to form the dendrimer-stabilized Fe3O4/Au NFs (for short, Fe3O4/Au DSNFs). The acquired Fe3O4/Au DSNFs possess an average size around 90 nm, display a high r1 relaxivity (1.22 mM−1 s−1), and exhibit good colloidal stability and cytocompatibility. The created hybrid DSNFs can be loaded within MAs without producing any toxicity to the cells. Through the mediation of MAs with a tumor homing and immune evasion property, the Fe3O4/Au DSNFs can be delivered to tumors more efficiently than those without MAs after intravenous injection, thus significantly improving the MR/CT imaging performance of tumors. The developed MA-mediated delivery system may hold great promise for enhanced tumor delivery of other contrast agents or nanomedicines for precision cancer nanomedicine applications.

LAPONITE®-stabilized iron oxide nanoparticles for in vivo MR imaging of tumors

2016 ◽  
Vol 4 (3) ◽  
pp. 474-482 ◽  
Author(s):  
Ling Ding ◽  
Yong Hu ◽  
Yu Luo ◽  
Jianzhi Zhu ◽  
Yilun Wu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Coprecipitation Method ◽  
Oxide Nanoparticles

LAPONITE®-stabilized iron oxide nanoparticles with great colloidal stability and high T2 relaxivity are synthesized by a facile controlled coprecipitation method, and can significantly enhance the contrast of tumors in vivo, indicating their tremendous potential in MR imaging applications.

scholarly journals Intrinsically Germanium-69-Labeled Iron Oxide Nanoparticles: Synthesis and In-Vivo Dual-Modality PET/MR Imaging

2014 ◽  
Vol 26 (30) ◽  
pp. 5119-5123 ◽  
Author(s):  
Rubel Chakravarty ◽  
Hector F. Valdovinos ◽  
Feng Chen ◽  
Christina M. Lewis ◽  
Paul A. Ellison ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Dual Modality ◽  
Nanoparticles Synthesis

Facile synthesis of folic acid-functionalized iron oxide nanoparticles with ultrahigh relaxivity for targeted tumor MR imaging

2015 ◽  
Vol 3 (28) ◽  
pp. 5720-5730 ◽  
Author(s):  
Jingchao Li ◽  
Yong Hu ◽  
Jia Yang ◽  
Wenjie Sun ◽  
Hongdong Cai ◽  
...  
Keyword(s):  
Folic Acid ◽  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Facile Synthesis

Folic acid-functionalized iron oxide nanoparticles with an ultrahigh r2 relaxivity can be formed for targeted MR imaging of tumors.

Endothelial Cell–derived Microparticles Loaded with Iron Oxide Nanoparticles: Feasibility of MR Imaging Monitoring in Mice

Radiology ◽  
2012 ◽  
Vol 263 (1) ◽  
pp. 169-178 ◽  
Author(s):  
Achraf Al Faraj ◽  
Florence Gazeau ◽  
Claire Wilhelm ◽  
Cécile Devue ◽  
Coralie L. Guérin ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles

Dual-targeting and excretable ultrasmall SPIONs for T1-weighted positive MR imaging of intracranial glioblastoma cells by targeting the lipoprotein receptor-related protein

2020 ◽  
Vol 8 (11) ◽  
pp. 2296-2306 ◽  
Author(s):  
Chengjuan Du ◽  
Xianping Liu ◽  
Hui Hu ◽  
Huiming Li ◽  
Luodan Yu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Oxide Nanoparticles ◽  
Lipoprotein Receptor ◽  
Related Protein ◽  
Ultrasmall Superparamagnetic Iron Oxide ◽  
Dual Targeting ◽  
Lipoprotein Receptor Related Protein

A multifunctional targeted nanoprobe composed of ultrasmall superparamagnetic iron oxide nanoparticles with surface-conjugated Angiopep-2 was successfully constructed for targeted MR imaging of intracranial glioblastoma.

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