Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles

Nanoscale ◽  
2015 ◽  
Vol 7 (33) ◽  
pp. 14080-14092 ◽  
Author(s):  
Lijue Chen ◽  
Xiaodong She ◽  
Tao Wang ◽  
Li He ◽  
Sarah Shigdar ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Resistance ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Acquired Drug Resistance ◽  
Colorectal Cancer Cells ◽  
Hollow Mesoporous Silica

scholarly journals Targeted delivery of mesoporous silica nanoparticles loaded monastrol into cancer cells: an in vitro study

2017 ◽  
Vol 7 (8) ◽  
pp. 549-555 ◽  
Author(s):  
Huzaifa Hanif ◽  
Samina Nazir ◽  
Kehkashan Mazhar ◽  
Muhammad Waseem ◽  
Shazia Bano ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
In Vitro Study ◽  
Vitro Study

The control of epidermal growth factor grafted on mesoporous silica nanoparticles for targeted delivery

2015 ◽  
Vol 3 (29) ◽  
pp. 6094-6104 ◽  
Author(s):  
Xiaodong She ◽  
Lijue Chen ◽  
Leonora Velleman ◽  
Chengpeng Li ◽  
Canzhong He ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Tof Sims ◽  
Epidermal Growth ◽  
Hollow Mesoporous Silica

ToF-SIMS was successfully applied to characterize and quantify the EGF grafted on hollow mesoporous silica nanoparticles.

Targeted delivery of quercetin loaded mesoporous silica nanoparticles to the breast cancer cells

2016 ◽  
Vol 1860 (10) ◽  
pp. 2065-2075 ◽  
Author(s):  
Abhijit Sarkar ◽  
Shatadal Ghosh ◽  
Sayantani Chowdhury ◽  
Bhawna Pandey ◽  
Parames C. Sil
Keyword(s):  
Breast Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Targeted Delivery ◽  
Breast Cancer Cells ◽  
Mesoporous Silica Nanoparticles

scholarly journals Bufalin reverses acquired drug resistance by inhibiting stemness in colorectal cancer cells

2017 ◽  
Vol 38 (3) ◽  
pp. 1420-1430 ◽  
Author(s):  
Jian Sun ◽  
Ke Xu ◽  
Yanyan Qiu ◽  
Hong Gao ◽  
Jianhua Xu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Acquired Drug Resistance ◽  
Colorectal Cancer Cells

Pd Nanosheet-Covered Hollow Mesoporous Silica Nanoparticles as a Platform for the Chemo-Photothermal Treatment of Cancer Cells

Small ◽  
2012 ◽  
Vol 8 (24) ◽  
pp. 3816-3822 ◽  
Author(s):  
Weijun Fang ◽  
Shaoheng Tang ◽  
Pengxin Liu ◽  
Xiaoliang Fang ◽  
Jiawei Gong ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Mesoporous Silica Nanoparticles ◽  
Photothermal Treatment ◽  
Hollow Mesoporous Silica

scholarly journals Application of mesoporous silica nanoparticles for drug delivery to cancer cells

2020 ◽  
pp. 5-15
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Efflux Pump ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Multi Drug Resistance

Cancer is one of the main causes of death worldwide. Chemotherapy is the most common method for cancer therapy which represent non-specific side effects on normal cells and tissues and drug resistance in cancer cells. There are two main mechanisms for Multi Drug Resistance (MDR) in cancer cells including: drug efflux pump and activation of anti-apoptotic pathways. Cancer chemotherapy disadvantages can be overcome by using nanoparticulate drug delivery systems like Mesoporous Silica Nanoparticles (MSNs) that have been used as drug delivery system since 2001. The present review included synthesis, targeted (active or passive) drug delivery to cancer cells, co-delivery of anticancer drugs and siRNA by MSNs and its toxicity. This review revealed that MSNs are good candidate for drug delivery to cancer cells due to its unique properties including: controllable pore and particle sizes, thermal and chemical stability, modifications of outer and inner surfaces of nanoparticles for drug and siRNA loading, attachment of ligand for targeted drug delivery, high drug loading capacity and controlled drug release, biocompatibility and biodegradation in aqueous medium.

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