Smart multifunctional drug delivery towards anticancer therapy harmonized in mesoporous nanoparticles

Nanoscale ◽  
2015 ◽  
Vol 7 (34) ◽  
pp. 14191-14216 ◽  
Author(s):  
Seonmi Baek ◽  
Rajendra K. Singh ◽  
Dipesh Khanal ◽  
Kapil D. Patel ◽  
Eun-Jung Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Anticancer Therapy ◽  
Mesoporous Nanoparticles

Effectiveness of the delivery of anticancer drugs and the efficacy of cancer therapy can be enhanced using smart multifunctional mesoporous nanoparticles.

Acid- and reduction-sensitive micelles for improving the drug delivery efficacy for pancreatic cancer therapy

2018 ◽  
Vol 6 (5) ◽  
pp. 1262-1270 ◽  
Author(s):  
Pu Wang ◽  
Jinxiu Wang ◽  
Haowen Tan ◽  
Shanfan Weng ◽  
Liying Cheng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Pancreatic Cancer ◽  
Cancer Therapy ◽  
Solid Tumors ◽  
Anticancer Drugs ◽  
Therapeutic Efficacy ◽  
Anticancer Therapy ◽  
The Poor ◽  
Pancreatic Cancer Therapy

One of the major challenges in anticancer therapy is the poor penetration of anticancer drugs into tumors, especially in solid tumors, resulting in decreased therapeutic efficacy in vivo.

A cyanine-based polymeric nanoplatform with microenvironment-driven cascaded responsiveness for imaging-guided chemo-photothermal combination anticancer therapy

2020 ◽  
Vol 8 (10) ◽  
pp. 2115-2122 ◽  
Author(s):  
Xia Yang ◽  
Jinxia An ◽  
Zhong Luo ◽  
Rui Yang ◽  
Shuzhen Yan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Therapy ◽  
Biological Barriers

Finding out how to overcome multistage biological barriers for nanocarriers in cancer therapy to obtain highly precise drug delivery is still a challenge.

Receptor-Based Combinatorial Nanomedicines

2021 ◽  
pp. 339-355
Author(s):  
Harshita Abul Barkat ◽  
Md Abul Barkat ◽  
Mohamad Taleuzzaman ◽  
Sabya Sachi Das ◽  
Md. Rizwanullah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Anticancer Therapy ◽  
Delivery Systems ◽  
Chemotherapeutic Agents ◽  
Multiple Drug ◽  
Conventional Drug ◽  
Drug Regimens

Nanotechnology-based drug-delivery systems, as an anticancer therapy tool, have shown significant potentials for the diagnosis and treatment of cancer. Recent studies have demonstrated that cancer therapy could be efficiently achieved by combinatorial therapies, approaches using multiple drug regimens for targeting cancers. However, their usages have been limited due to shorter half-lives of chemotherapeutic agents, insignificant targetability to tumor sites and suboptimal levels of co-administered conventional drug moieties. Thus, nanotechnology-based drug-delivery systems with effective targetability have played a crucial role to overcome the limitations and challenges associated with conventional therapies and also have provided greater therapeutic efficacy. Herein, the authors have focused on various drug-incorporated combinatorial nanocarrier systems, the significance of various receptors-associated strategies, and various targeted delivery approaches for chemotherapeutic agents.

Rosin-based block copolymer intracellular delivery nanocarriers with reduction-responsive sheddable coronas for cancer therapy

2016 ◽  
Vol 7 (29) ◽  
pp. 4751-4760 ◽  
Author(s):  
So Young An ◽  
Sung Hwa Hong ◽  
Chuanbing Tang ◽  
Jung Kwon Oh
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Colloidal Stability ◽  
Intracellular Delivery ◽  
Intracellular Drug Delivery

Rosin-based, reduction-responsive block copolymer-based nanocarriers exhibiting excellent colloidal stability enabling the delivery of anticancer drugs to cancerous tissues for the enhanced release of encapsulated drugs, offering great versatility as intracellular drug-delivery nanocarriers for cancer therapy.

scholarly journals Differentially cross-linkable core–shell nanofibers for tunable delivery of anticancer drugs: synthesis, characterization and their anticancer efficacy

RSC Advances ◽  
2014 ◽  
Vol 4 (72) ◽  
pp. 38263-38272 ◽  
Author(s):  
S. Uday Kumar ◽  
I. Matai ◽  
P. Dubey ◽  
B. Bhushan ◽  
A. Sachdev ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drugs ◽  
Controlled Drug Delivery ◽  
Anticancer Therapy ◽  
Core Shell ◽  
Anticancer Efficacy

This work introduces a new dimension for controlled drug delivery by nanofiber based scaffolds for anticancer therapy.

Magnetic liposomes for light-sensitive drug delivery and combined photothermal–chemotherapy of tumors

2019 ◽  
Vol 7 (7) ◽  
pp. 1096-1106 ◽  
Author(s):  
Song Shen ◽  
Danhuang Huang ◽  
Jin Cao ◽  
Ying Chen ◽  
Xin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Targeted Delivery ◽  
Therapeutic Efficacy

The targeted delivery of anticancer drugs for improving the therapeutic efficacy and reducing the side effects has attracted great attention in cancer therapy.

scholarly journals Systemic and Local Silk-Based Drug Delivery Systems for Cancer Therapy

Cancers ◽  
2021 ◽  
Vol 13 (21) ◽  
pp. 5389
Author(s):  
Anna Florczak ◽  
Tomasz Deptuch ◽  
Kamil Kucharczyk ◽  
Hanna Dams-Kozlowska
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Drugs ◽  
Kinase Inhibitors ◽  
Drug Carrier ◽  
Inorganic Nanoparticles ◽  
Entire Body ◽  
Delivery Platform ◽  
Particle Preparation ◽  
Systemic Drug Delivery

For years, surgery, radiotherapy, and chemotherapy have been the gold standards to treat cancer, although continuing research has sought a more effective approach. While advances can be seen in the development of anticancer drugs, the tools that can improve their delivery remain a challenge. As anticancer drugs can affect the entire body, the control of their distribution is desirable to prevent systemic toxicity. The application of a suitable drug delivery platform may resolve this problem. Among other materials, silks offer many advantageous properties, including biodegradability, biocompatibility, and the possibility of obtaining a variety of morphological structures. These characteristics allow the exploration of silk for biomedical applications and as a platform for drug delivery. We have reviewed silk structures that can be used for local and systemic drug delivery for use in cancer therapy. After a short description of the most studied silks, we discuss the advantages of using silk for drug delivery. The tables summarize the descriptions of silk structures for the local and systemic transport of anticancer drugs. The most popular techniques for silk particle preparation are presented. Further prospects for using silk as a drug carrier are considered. The application of various silk biomaterials can improve cancer treatment by the controllable delivery of chemotherapeutics, immunotherapeutics, photosensitizers, hormones, nucleotherapeutics, targeted therapeutics (e.g., kinase inhibitors), and inorganic nanoparticles, among others.

scholarly journals Hyaluronic Acid-Based Theranostic Nanomedicines for Targeted Cancer Therapy

Cancers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 940 ◽  
Author(s):  
So Yun Lee ◽  
Moon Sung Kang ◽  
Woo Yeup Jeong ◽  
Dong-Wook Han ◽  
Ki Su Kim
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Cancer Therapy ◽  
Tumor Cells ◽  
Binding Affinity ◽  
Anticancer Drugs ◽  
Cancer Therapies ◽  
Targeted Cancer Therapy ◽  
Cancer Treatments ◽  
High Binding Affinity

Hyaluronic acid (HA) is a natural mucopolysaccharide and has many useful advantages, including biocompatibility, non-immunogenicity, chemical versatility, non-toxicity, biodegradability, and high hydrophilicity. Numerous tumor cells overexpress several receptors that have a high binding affinity for HA, while these receptors are poorly expressed in normal body cells. HA-based drug delivery carriers can offer improved solubility and stability of anticancer drugs in biological environments and allow for the targeting of cancer treatments. Based on these benefits, HA has been widely investigated as a promising material for developing the advanced clinical cancer therapies in various formulations, including nanoparticles, micelles, liposomes, and hydrogels, combined with other materials. We describe various approaches and findings showing the feasibility of improvement in theragnosis probes through the application of HA.

scholarly journals Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review

2013 ◽  
Vol 49 (4) ◽  
pp. 629-643 ◽  
Author(s):  
Swatantra Kumar Singh Kushwaha ◽  
Saurav Ghoshal ◽  
Awani Kumar Rai ◽  
Satyawan Singh
Keyword(s):  
Carbon Nanotubes ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Loading ◽  
Anticancer Therapy ◽  
Modern Times ◽  
Novel Drug Delivery System ◽  
Considerable Work ◽  
Novel Drug ◽  
High Drug Loading

Carbon nanotubes (CNTs) were discovered in 1991 and shown to have certain unique physicochemical properties, attracting considerable interest in their application in various fields including drug delivery. The unique properties of CNTs such as ease of cellular uptake, high drug loading, thermal ablation, among others, render them useful for cancer therapy. Cancer is one of the most challenging diseases of modern times because its therapy involves distinguishing normal healthy cells from affected cells. Here, CNTs play a major role because phenomena such as EPR, allow CNTs to distinguish normal cells from affected ones, the Holy Grail in cancer therapy. Considerable work has been done on CNTs as drug delivery systems over the last two decades. However, concerns over certain issues such as biocompatibility and toxicity have been raised and warrant extensive research in this field.

scholarly journals Nanocarriers Used in Drug Delivery to Enhance Immune System in Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1167
Author(s):  
Giovanna C. N. B. Lôbo ◽  
Karen L. R. Paiva ◽  
Ana Luísa G. Silva ◽  
Marina M. Simões ◽  
Marina A. Radicchi ◽  
...  
Keyword(s):  
Public Health ◽  
Drug Delivery ◽  
Immune System ◽  
Cancer Therapy ◽  
Adverse Effects ◽  
Tumor Cells ◽  
Surface Area ◽  
Materials Science ◽  
Anticancer Therapy ◽  
Cancer Therapies

Cancer, a group of diseases responsible for the second largest cause of global death, is considered one of the main public health problems today. Despite the advances, there are still difficulties in the development of more efficient cancer therapies and fewer adverse effects for the patients. In this context, nanobiotechnology, a materials science on a nanometric scale specified for biology, has been developing and acquiring prominence for the synthesis of nanocarriers that provide a wide surface area in relation to volume, better drug delivery, and a maximization of therapeutic efficiency. Among these carriers, the ones that stand out are those focused on the activation of the immune system. The literature demonstrates the importance of this system for anticancer therapy, given that the best treatment for this disease also activates the immune system to recognize, track, and destroy all remaining tumor cells.

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