MRI-visible liposome nanovehicles for potential tumor-targeted delivery of multimodal therapies

Nanoscale ◽  
2015 ◽  
Vol 7 (30) ◽  
pp. 12843-12850 ◽  
Author(s):  
Lili Ren ◽  
Shizhen Chen ◽  
Haidong Li ◽  
Zhiying Zhang ◽  
Chaohui Ye ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Real Time ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Liposomal Drug ◽  
Targeted Drug ◽  
Liposomal Drug Delivery

The theranostic liposomal drug delivery system can act as an effective nanoplatform integrating targeted drug delivery, controlled release, MRI real-time monitoring and diagnostic functions.

scholarly journals Primary and Novel Approaches in Colon Targeted Drug Delivery System: A Review

2015 ◽  
Vol 3 (02) ◽  
pp. 37-57
Author(s):  
Komal . ◽  
Ujjwal Nautiyal ◽  
Ramandeep , Anita Devi Singh ◽  
Anita Devi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Local Treatment ◽  
Systemic Delivery ◽  
Colonic Delivery ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

Targeted drug delivery into the colon is highly desirable for local treatment of a variety of bowel diseases such as ulcerative colitis, Crohn’s disease, amoeabiasis , colonic cancer, local treatment of colonic pathologies, and systemic delivery of protein and peptide drugs. Colonic delivery refers to targeted delivery of drugs into the lower GI tract, which occurs primarily in the large intestine (i.e. colon). The colon specific drug delivery system (CDDS) should be capable of protecting the drug en route to the colon i.e. drug release and absorption should not occur in the stomach as well as the small intestine, and neither the bioactive agent should be degraded in either of the dissolution sites but only released and absorbed once the system reaches the colon. Different approaches are designed based on prodrug formulation, pHsensitivity, time-dependency (lag time), microbial degradation and osmotic pressure etc to formulate the different dosage forms like tablets, capsules, multiparticulates, microspheres, liposomes for colon targeting. The efficiency of drug delivery system is evaluated using different in vitro and in vivo release studies. This review article discusses, in brief, introduction to targeted drug delivery system, anatomy and physiology of the colon and approaches utilized in the colon targeted drug delivery system.

A gold nanoflower-based traceable drug delivery system for intracellular SERS imaging-guided targeted chemo-phototherapy

2018 ◽  
Vol 6 (19) ◽  
pp. 3030-3039 ◽  
Author(s):  
Chunyuan Song ◽  
Yanxia Dou ◽  
Lihui Yuwen ◽  
Youzhi Sun ◽  
Chen Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Drug Encapsulation ◽  
High Drug ◽  
Gold Nanoflowers ◽  
Sers Imaging ◽  
Targeted Drug

A novel traceable and targeted drug delivery nanosystem with high drug encapsulation and pH-controlled release was prepared based on gold nanoflowers for efficient intracellular SERS imaging-guided chemo-phototherapy.

scholarly journals ADAM9-Responsive Mesoporous Silica Nanoparticles for Targeted Drug Delivery in Pancreatic Cancer

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3321
Author(s):  
Etienne J. Slapak ◽  
Lily Kong ◽  
Mouad el Mandili ◽  
Rienk Nieuwland ◽  
Alexander Kros ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Conditioned Medium ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Pdac Cell ◽  
Targeted Drug

Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate of all cancers. This poor prognosis results from the lack of efficient systemic treatment regimens, demanding high-dose chemotherapy that causes severe side effects. To overcome dose-dependent toxicities, we explored the efficacy of targeted drug delivery using a protease-dependent drug-release system. To this end, we developed a PDAC-specific drug delivery system based on mesoporous silica nanoparticles (MSN) functionalized with an avidin–biotin gatekeeper system containing a protease linker that is specifically cleaved by tumor cells. Bioinformatic analysis identified ADAM9 as a PDAC-enriched protease, and PDAC cell-derived conditioned medium efficiently cleaved protease linkers containing ADAM9 substrates. Cleavage was PDAC specific as conditioned medium from leukocytes was unable to cleave the ADAM9 substrate. Protease linker-functionalized MSNs were efficiently capped with avidin, and cap removal was confirmed to occur in the presence of PDAC cell-derived ADAM9. Subsequent treatment of PDAC cells in vitro with paclitaxel-loaded MSNs indeed showed high cytotoxicity, whereas no cell death was observed in white blood cell-derived cell lines, confirming efficacy of the nanoparticle-mediated drug delivery system. Taken together, this research introduces a novel ADAM9-responsive, protease-dependent, drug delivery system for PDAC as a promising tool to reduce the cytotoxicity of systemic chemotherapy.

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