scholarly journals Multifunctional self-assembled composite colloids and their application to SERS detection

Nanoscale ◽  
2015 ◽  
Vol 7 (23) ◽  
pp. 10377-10381 ◽  
Author(s):  
Andrea La Porta ◽  
Ana Sánchez-Iglesias ◽  
Thomas Altantzis ◽  
Sara Bals ◽  
Marek Grzelczak ◽  
...  

Development of a novel hybrid colloidal system suitable for surface-enhanced Raman spectroscopy analysis.

2021 ◽  
pp. 000370282110329
Author(s):  
Ling Wang ◽  
Mario O. Vendrell-Dones ◽  
Chiara Deriu ◽  
Sevde Doğruer ◽  
Peter de B. Harrington ◽  
...  

Recently there has been upsurge in reports that illicit seizures of cocaine and heroin have been adulterated with fentanyl. Surface-enhanced Raman spectroscopy (SERS) provides a useful alternative to current screening procedures that permits detection of trace levels of fentanyl in mixtures. Samples are solubilized and allowed to interact with aggregated colloidal nanostars to produce a rapid and sensitive assay. In this study, we present the quantitative determination of fentanyl in heroin and cocaine using SERS, using a point-and-shoot handheld Raman system. Our protocol is optimized to detect pure fentanyl down to 0.20 ± 0.06 ng/mL and can also distinguish pure cocaine and heroin at ng/mL levels. Multiplex analysis of mixtures is enabled by combining SERS detection with principal component analysis and super partial least squares regression discriminate analysis (SPLS-DA), which allow for the determination of fentanyl as low as 0.05% in simulated seized heroin and 0.10% in simulated seized cocaine samples.


Nanoscale ◽  
2018 ◽  
Vol 10 (13) ◽  
pp. 5897-5905 ◽  
Author(s):  
Zhen Li ◽  
Shouzhen Jiang ◽  
Yanyan Huo ◽  
Tingyin Ning ◽  
Aihua Liu ◽  
...  

We explore the variation of SERS performance towards two different Ag NP layers using multilayer GO as a spacer.


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