Controlled implant/soft tissue interaction by nanoscale surface modifications of 3D porous titanium implants

Nanoscale ◽  
2015 ◽  
Vol 7 (21) ◽  
pp. 9908-9918 ◽  
Author(s):  
Elisabeth Rieger ◽  
Agnès Dupret-Bories ◽  
Laetitia Salou ◽  
Marie-Helene Metz-Boutigue ◽  
Pierre Layrolle ◽  
...  
Keyword(s):  
Surface Modification ◽  
Soft Tissue ◽  
Surface Modifications ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Tissue Response ◽  
Soft Tissue Response ◽  
Modification Of Titanium

Nanoscale surface modification of titanium microbeads can control the soft tissue response in vitro and in vivo.

Soft tissue response to zirconia and titanium implant abutments: an in vivo within-subject comparison

2012 ◽  
Vol 39 (10) ◽  
pp. 995-1001 ◽  
Author(s):  
Ralph van Brakel ◽  
Gert J. Meijer ◽  
Jan Willem Verhoeven ◽  
John Jansen ◽  
Cornelis de Putter ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Titanium Implant ◽  
Tissue Response ◽  
Implant Abutments ◽  
Soft Tissue Response ◽  
Subject Comparison

scholarly journals In Vivo Investigation of Soft Tissue Response of Novel Silver/Poly(Vinyl Alcohol)/ Graphene and Silver/Poly(Vinyl Alcohol)/Chitosan/Graphene Hydrogels Aimed for Medical Applications – The First Experience

2018 ◽  
Vol 68 (3) ◽  
pp. 321-339 ◽  
Author(s):  
Tijana Lužajić Božinovski ◽  
Danica Marković ◽  
Vera Todorović ◽  
Bogomir Prokić Bolka ◽  
Ivan Milošević ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Vinyl Alcohol ◽  
Subcutaneous Tissue ◽  
Tissue Response ◽  
Surrounding Tissue ◽  
Poly Vinyl Alcohol ◽  
Medical Applications ◽  
Capsule Thickness ◽  
Soft Tissue Response

Abstract In this paper, we have shown for the fi rst time the soft tissue response of novel silver/ poly(vinyl alcohol)/graphene (Ag/PVA/Gr) and silver/poly(vinyl alcohol)/chitosan/ graphene (Ag/PVA/CHI/Gr) nanocomposite hydrogels aimed for medical applications. These novel hydrogels were produced by in situ electrochemical synthesis of silver nanoparticles in the polymer matrices as described in our previously published works. Both Ag/PVA/Gr and Ag/PVA/CHI/Gr, as well as controls Ag/PVA, Ag/PVA/CHI and commercial Suprasorb©hydrogel discs, were implanted in the subcutaneous tissue of rats. Implants with the surrounding tissue were dissected after post-implantation on days 7, 15, 30 and 60, and then processed for histological examination. The tissue irritation index (TIrI) score, according to ISO 10993-6, 2007, as well as the number of leukocytes in the peri-implant zone and connective tissue capsule thickness were examined. The results show that each TIrI score, the leukocyte number around the implanted materials and capsule thickness gradually decreased during the observation period. At the endpoint of follow-up, the Ag/PVA/CHI/Gr implant was surrounded with a thinner capsule, while both the TIrI score and the number of leukocytes of the peri-implant zone were greater compared to the Ag/PVA/Gr implant. Despite the observed differences, we can conclude that our in vivo experiment suggested that both novel hydrogels were biocompatible and suitable for medical use.

Influence of surface modification of titanium implants on improving osseointegration: An in vitro study

2021 ◽  
Author(s):  
Mohini Gajiwala ◽  
Jyoti Paliwal ◽  
Syed Yawer Husain ◽  
Ashish Dadarwal ◽  
Rajni Kalla ◽  
...  
Keyword(s):  
Surface Modification ◽  
In Vitro Study ◽  
Titanium Implants ◽  
Vitro Study ◽  
Modification Of Titanium

scholarly journals Will Zirconia Implants Replace Titanium Implants?

2021 ◽  
Vol 11 (15) ◽  
pp. 6776
Author(s):  
Liana Preto Webber ◽  
Hsun-Liang Chan ◽  
Hom-Lay Wang
Keyword(s):  
Soft Tissue ◽  
Clinical Results ◽  
Titanium Implants ◽  
Tissue Response ◽  
Advantages And Disadvantages ◽  
New Material ◽  
Soft Tissue Response ◽  
Zirconia Implants

This review aims to discuss the advantages and disadvantages of zirconia implants compared with titanium implants. Moreover, it intends to review the relevant available long-term literature of these two materials regarding osteointegration, soft-tissue, microbiota, and peri-implantitis, focusing on clinical results. Briefly, titanium implants are a reliable alternative for missing teeth; however, they are not incapable of failure. In an attempt to provide an alternative implant material, implants made from ceramic-derivate products were developed. Owing to its optimal osseointegration competence, biocompatibility, and esthetic proprieties, zirconium dioxide (ZrO2), also known as zirconia, has gained popularity among researchers and clinicians, being a metal-free alternative for titanium implants with its main use in the anterior esthetic zones. This type of implant may present similar osseointegration as those noted on titanium implants with a greater soft-tissue response. Furthermore, this material does not show corrosion as its titanium analog, and it is less susceptible to bacterial adhesion. Lastly, even presenting a similar inflammatory response to titanium, zirconia implants offer less biofilm formation, suggesting less susceptibility to peri-implantitis. However, it is a relatively new material that has been commercially available for a decade; consequently, the literature still lacks studies with long follow-up periods.

Surface modification of titanium by anodic oxidation in phosphoric acid at low potentials. Part 2. In vitro and in vivo study

2013 ◽  
Vol 45 (9) ◽  
pp. 1395-1401 ◽  
Author(s):  
A. Gomez Sanchez ◽  
W. Schreiner ◽  
J. Ballarre ◽  
A. Cisilino ◽  
G. Duffó ◽  
...  
Keyword(s):  
Surface Modification ◽  
Phosphoric Acid ◽  
Anodic Oxidation ◽  
In Vivo Study ◽  
Modification Of Titanium

A Comparative Study of Porous Titanium with Different Surface Modification Implanted in Dogs

2007 ◽  
Vol 342-343 ◽  
pp. 561-564 ◽  
Author(s):  
Chao Yong Zhao ◽  
Hu Li ◽  
T. Yuan ◽  
Hong Song Fan ◽  
Xing Dong Zhang ◽  
...  
Keyword(s):  
Close Contact ◽  
Alkali Treatment ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Tissue Response ◽  
Implantation Time ◽  
Heat Treated ◽  
The Mean ◽  
Push Out

This study was carried out to investigate the effect of acid-alkali treatment and alkaliheat treatment on the push-out strength and tissue response of the porous titanium in vivo. Porous titanium with different treatment was implanted in dog bony site for 2 months and 5 months and the push-out strength was tested. At 2 months, the mean push-out strengths of the acid-alkali treated and alkali-heat treated porous titanium were 11.3 and 15 MPa, respectively. At 5 months, the values reached 29.8 and 35 MPa, respectively. Histological observation showed a close contact between implants and bone, and more bone tissue filled inside the pores of porous titanium increasing with implantation time. The results indicated higher bonding strength between bone and porous titanium in alkali-heat treated samples. Therefore, alkali-heat treatment can provide porous titanium implants with better fixation as a bone substitute for clinical use under load-bearing conditions.

scholarly journals Surface treatments applied on titanium implants

2015 ◽  
Vol 26 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Sorin Cosmin Cosma ◽  
Nicolae Balc ◽  
Marioara Moldovan ◽  
Cristina Ștefana Miron-Borzan
Keyword(s):  
Surface Modifications ◽  
Surface Treatments ◽  
Titanium Implants ◽  
Denatured Protein ◽  
Adhesion Behavior ◽  
Recent Developments ◽  
Behavior Profiling ◽  
Biochemical Signals

AbstractThe aim of this systematic review was to identify new methods of surface treatments applied on titanium grafts and their clinical and histological outcomes, including different routes for surface treatments, respectively the results of in vitro or in vivo tests. These surface modifications analysed meet three main requirements: to prevent nonspecific absorption of denatured protein on the surface, to attract native tissue cells or progenitor cells capable of differentiation in an appropriate manner or to facilitate biochemical signals to induce biochemical healing mechanisms. Therefore, cells will recognize these surface modifications and will be influenced in their adhesion behavior, profiling and differentiation. This review summarizes some of the recent developments in coatings for medical field.

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