Nanoparticles speckled by ready-to-conjugate lanthanide complexes for multimodal imaging

Nanoscale ◽  
2015 ◽  
Vol 7 (36) ◽  
pp. 14829-14837 ◽  
Author(s):  
Vasudevanpillai Biju ◽  
Morihiko Hamada ◽  
Kenji Ono ◽  
Sakiko Sugino ◽  
Takashi Ohnishi ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Multimodal Imaging ◽  
Lanthanide Complexes ◽  
Biomedical Imaging

Multimodal and multifunctional contrast agents receive enormous attention in the biomedical imaging field.

scholarly journals Recent development of nanoparticles for molecular imaging

2017 ◽  
Vol 375 (2107) ◽  
pp. 20170022 ◽  
Author(s):  
Jonghoon Kim ◽  
Nohyun Lee ◽  
Taeghwan Hyeon
Keyword(s):  
Surface Modification ◽  
Molecular Imaging ◽  
Contrast Agents ◽  
Multimodal Imaging ◽  
High Sensitivity ◽  
Accurate Diagnosis ◽  
Biological Processes ◽  
Future Perspectives ◽  
Cellular Functions ◽  
Diagnosis Of Diseases

Molecular imaging enables us to non-invasively visualize cellular functions and biological processes in living subjects, allowing accurate diagnosis of diseases at early stages. For successful molecular imaging, a suitable contrast agent with high sensitivity is required. To date, various nanoparticles have been developed as contrast agents for medical imaging modalities. In comparison with conventional probes, nanoparticles offer several advantages, including controllable physical properties, facile surface modification and long circulation time. In addition, they can be integrated with various combinations for multimodal imaging and therapy. In this opinion piece, we highlight recent advances and future perspectives of nanomaterials for molecular imaging. This article is part of the themed issue ‘Challenges for chemistry in molecular imaging’.

scholarly journals Air-Filled Microbubbles Based on Albumin Functionalized with Gold Nanocages and Zinc Phthalocyanine for Multimodal Imaging

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1161
Author(s):  
Elizaveta A. Maksimova ◽  
Roman A. Barmin ◽  
Polina G. Rudakovskaya ◽  
Olga A. Sindeeva ◽  
Ekaterina S. Prikhozhdenko ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Physicochemical Parameters ◽  
Multimodal Imaging ◽  
Biomedical Applications ◽  
Zinc Phthalocyanine ◽  
Fluorescence Tomography ◽  
Raster Scanning ◽  
Air Core ◽  
Gold Nanocages ◽  
Potential Use

Microbubbles are intravascular contrast agents clinically used in diagnostic sonography, echocardiography, and radiology imaging applications. However, up to date, the idea of creating microbubbles with multiple functionalities (e.g., multimodal imaging, photodynamic therapy) remained a challenge. One possible solution is the modification of bubble shells by introducing specific compounds responsible for such functions. In the present work, air-core microbubbles with the shell consisting of bovine serum albumin, albumin-coated gold nanocages, and zinc phthalocyanine were prepared using the sonication method. Various physicochemical parameters such as stability over time, size, and concentration were investigated to prove the potential use of these microbubbles as contrast agents. This work shows that hybrid microbubbles have all the necessary properties for multimodal imaging (ultrasound, raster-scanning microscopy, and fluorescence tomography), which demonstrate superior characteristics for potential theranostic and related biomedical applications.

scholarly journals A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

Sensors ◽  
2020 ◽  
Vol 20 (19) ◽  
pp. 5595 ◽  
Author(s):  
Victor T.C. Tsang ◽  
Xiufeng Li ◽  
Terence T.W. Wong
Keyword(s):  
Contrast Agents ◽  
Biomedical Imaging ◽  
Imaging Modality ◽  
Biological Tissues ◽  
Tissue Imaging ◽  
Imaging Tool ◽  
Endogenous Contrast ◽  
Deep Tissue Imaging ◽  
Molecular Specificity ◽  
System Configurations

Optical-based sensing approaches have long been an indispensable way to detect molecules in biological tissues for various biomedical research and applications. The advancement in optical microscopy is one of the main drivers for discoveries and innovations in both life science and biomedical imaging. However, the shallow imaging depth due to the use of ballistic photons fundamentally limits optical imaging approaches’ translational potential to a clinical setting. Photoacoustic (PA) tomography (PAT) is a rapidly growing hybrid imaging modality that is capable of acoustically detecting optical contrast. PAT uniquely enjoys high-resolution deep-tissue imaging owing to the utilization of diffused photons. The exploration of endogenous contrast agents and the development of exogenous contrast agents further improve the molecular specificity for PAT. PAT’s versatile design and non-invasive nature have proven its great potential as a biomedical imaging tool for a multitude of biomedical applications. In this review, representative endogenous and exogenous PA contrast agents will be introduced alongside common PAT system configurations, including the latest advances of all-optical acoustic sensing techniques.

Multimodal imaging: Nanocrystal loaded PLA-shelled contrast agents

2015 ◽  
Author(s):  
Nutte Teraphongphom ◽  
Peter Chhour ◽  
John R. Eisenbrey ◽  
Pratap C. Naha ◽  
Walter R. T. Witschey ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Multimodal Imaging

Magnetic nanoparticles as contrast agents in biomedical imaging: recent advances in iron- and manganese-based magnetic nanoparticles

2014 ◽  
Vol 46 (2) ◽  
pp. 142-154 ◽  
Author(s):  
Charlette Felton ◽  
Alokita Karmakar ◽  
Yashraj Gartia ◽  
Punnamchandar Ramidi ◽  
Alexandru S. Biris ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Contrast Agents ◽  
Biomedical Imaging ◽  
Recent Advances ◽  
Iron And Manganese
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