Preparation of biodegradable PEGylated pH/reduction dual-stimuli responsive nanohydrogels for controlled release of an anti-cancer drug

Nanoscale ◽  
2015 ◽  
Vol 7 (28) ◽  
pp. 12051-12060 ◽  
Author(s):  
Tingting Zhou ◽  
Xubo Zhao ◽  
Lei Liu ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drug ◽  
Cancer Drugs ◽  
Stimuli Responsive ◽  
Anti Cancer ◽  
Ph Reduction ◽  
Stimuli Sensitive

Monodisperse biodegradable PEGylated pH and reduction dual-stimuli sensitive PMPB nanohydrogels were prepared as a drug delivery system for controlled release anti-cancer drugs.

Dual stimuli-responsive multi-drug delivery system for the individually controlled release of anti-cancer drugs

2015 ◽  
Vol 51 (8) ◽  
pp. 1475-1478 ◽  
Author(s):  
Wang Xiao ◽  
Xuan Zeng ◽  
Hang Lin ◽  
Kai Han ◽  
Hui-Zhen Jia ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drugs ◽  
Stimuli Responsive ◽  
Anti Cancer

A dual stimuli-responsive multi-drug delivery system was developed for “cancer cocktail therapy”. Release behaviors of the dual drugs could be controlled separately by appropriate stimulation.

scholarly journals Correction: Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 17041-17041 ◽  
Author(s):  
Xubo Zhao ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Folate Receptor ◽  
Cancer Drugs ◽  
Receptor Targeting ◽  
Anti Cancer ◽  
Folate Receptor Targeting

Correction for ‘Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs’ by Xubo Zhao et al., RSC Adv., 2014, 4, 24232–24239.

Biocompatible graphene oxide as a folate receptor-targeting drug delivery system for the controlled release of anti-cancer drugs

RSC Advances ◽  
2014 ◽  
Vol 4 (46) ◽  
pp. 24232-24239 ◽  
Author(s):  
Xubo Zhao ◽  
Peng Liu
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Folate Receptor ◽  
Cancer Drugs ◽  
Ph Responsive ◽  
Anti Cancer ◽  
Folate Receptor Targeting

A novel graphene oxide (GO)-based nanocarrier has been designed for the targeting and pH-responsive controlled release of anti-cancer drugs.

A facile PEG/thiol-functionalized nanographene oxide carrier with an appropriate glutathione-responsive switch

2020 ◽  
Vol 11 (12) ◽  
pp. 2194-2204 ◽  
Author(s):  
Bingjie Hao ◽  
Wei Li ◽  
Sen Zhang ◽  
Ying Zhu ◽  
Yongjun Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drugs ◽  
Anti Cancer ◽  
Smart Drug ◽  
Smart Drug Delivery

A novel nanographene oxide/PEG-based bioreduction-responsive smart drug delivery system with a GSH-responsive disulfide linker as the controlled release switch can selectively release anti-cancer drugs in cancer cells.

scholarly journals pH/Reduction Dual-Stimuli-Responsive Cross-Linked Micelles Based on Multi-Functional Amphiphilic Star Copolymer: Synthesis and Controlled Anti-Cancer Drug Release

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 82 ◽  
Author(s):  
Yunwei Huang ◽  
Jingye Yan ◽  
Shiyuan Peng ◽  
Zilun Tang ◽  
Cuiying Tan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Thermodynamic Analysis ◽  
Electrostatic Interaction ◽  
Cancer Drug ◽  
Stimuli Responsive ◽  
Anti Cancer ◽  
Ph Reduction ◽  
Star Copolymer

Novel approach has been constructed for preparing the amphiphilic star copolymer pH/reduction stimuli-responsive cross-linked micelles (SCMs) as a smart drug delivery system for the well-controlled anti-tumor drug doxorubicin (DOX) release. The SCMs had a low CMC value of 5.3 mg/L. The blank and DOX-loaded SCMs both had a spherical shape with sizes around 100–180 nm. In addition, the good stability and well pH/reduction-sensitivity of the SCMs were determined by dynamic light scattering (DLS) as well. The SCMs owned a low release of DOX in bloodstream and normal tissues while it had a fast release in tumor higher glutathione (GSH) concentration and/or lower pH value conditions, which demonstrates their pH/reduction dual-responsiveness. Furthermore, we conducted the thermodynamic analysis to study the interactions between the DOX and polymer micelles in the DOX release process. The values of the thermodynamic parameters at pH 7.4 and at pH 5.0 conditions indicated that the DOX release was endothermic and controlled mainly by the forces of an electrostatic interaction. At pH 5.0 with 10 mM GSH condition, electrostatic interaction, chemical bond, and hydrophobic interactions contributed together on DOX release. With the low cytotoxicity of blank SCMs and well cytotoxicity of DOX-loaded SCMs, the results indicated that the SCMs could form a smart cancer microenvironment-responsive drug delivery system. The release kinetic and thermodynamic analysis offer a theoretical foundation for the interaction between drug molecules and polymer matrices, which helps provide a roadmap for the oriented design and control of anti-cancer drug release for cancer therapy.

Reduction-responsive gold-nanoparticle-conjugated Pluronic micelles: an effective anti-cancer drug delivery system

2012 ◽  
Vol 22 (36) ◽  
pp. 18864 ◽  
Author(s):  
Youhua Tao ◽  
Jiangfeng Han ◽  
Chunting Ye ◽  
Tima Thomas ◽  
Huanyu Dou
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticle ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cancer Drug Delivery

scholarly journals A novel liver-specific fluorescent anti-cancer drug delivery system using indocyanine green

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yoshinori Inagaki ◽  
Takashi Kokudo ◽  
Mako Kamiya ◽  
Shin-nosuke Uno ◽  
Masumitsu Sato ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Indocyanine Green ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cancer Drug Delivery

scholarly journals Novel 3D printed device with integrated macroscale magnetic field triggerable anti-cancer drug delivery system

2020 ◽  
Vol 192 ◽  
pp. 111068 ◽  
Author(s):  
Kejing Shi ◽  
Rodrigo Aviles-Espinosa ◽  
Elizabeth Rendon-Morales ◽  
Lisa Woodbine ◽  
Mohammed Maniruzzaman ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cancer Drug ◽  
Anti Cancer ◽  
3D Printed ◽  
Cancer Drug Delivery

A two-photon responsive naphthyl tagged p-hydroxyphenacyl based drug delivery system: uncaging of anti-cancer drug in the phototherapeutic window with real-time monitoring

2020 ◽  
Vol 56 (69) ◽  
pp. 9986-9989
Author(s):  
Amit Kumar Singh ◽  
Moumita Kundu ◽  
Samrat Roy ◽  
Biswajit Roy ◽  
Sk. Sheriff Shah ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Real Time ◽  
Drug Delivery System ◽  
Delivery System ◽  
Photon Absorption ◽  
Cancer Drug ◽  
Real Time Monitoring ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Anti Cancer

A two-photon responsive drug delivery system having two-photon absorption (TPA) in the phototherapeutic window with a two-photon uncaging cross-section ≥10 GM and exhibiting real-time monitoring of anti-cancer drug release.

Sign in / Sign up

Export Citation Format

Share Document