scholarly journals Targeting ferritin receptors for the selective delivery of imaging and therapeutic agents to breast cancer cells

Nanoscale ◽  
2015 ◽  
Vol 7 (15) ◽  
pp. 6527-6533 ◽  
Author(s):  
S. Geninatti Crich ◽  
M. Cadenazzi ◽  
S. Lanzardo ◽  
L. Conti ◽  
R. Ruiu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Therapeutic Agents ◽  
Imaging Agents ◽  
Selective Uptake ◽  
Selective Delivery ◽  
Ferritin Receptors ◽  
Inflammatory Action ◽  
Simultaneous Delivery

Horse Spleen Apoferritin has been exploited to deliver simultaneously therapeutic and imaging agents to breast cancer cells via the ferritin transporting route. The selective uptake has been investigated by MRI, and exploited for the simultaneous delivery of Curcumin, a compound with strong anti-neoplastic and anti-inflammatory action.

scholarly journals Drug-Triggered Self-Assembly of Linear Polymer into Nanoparticles for Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs in Breast Cancer Cells

ACS Omega ◽  
2017 ◽  
Vol 2 (12) ◽  
pp. 8730-8740 ◽  
Author(s):  
Sandeep Palvai ◽  
Libi Anandi ◽  
Sujit Sarkar ◽  
Meera Augustus ◽  
Sudip Roy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Self Assembly ◽  
Breast Cancer Cells ◽  
Linear Polymer ◽  
Hydrophilic Drugs ◽  
Simultaneous Delivery

scholarly journals Selective delivery of an anticancer drug with aptamer-functionalized liposomes to breast cancer cells in vitro and in vivo

2013 ◽  
Vol 1 (39) ◽  
pp. 5288 ◽  
Author(s):  
Hang Xing ◽  
Li Tang ◽  
Xujuan Yang ◽  
Kevin Hwang ◽  
Wendan Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Anticancer Drug ◽  
Breast Cancer Cells ◽  
Selective Delivery

The presence of Estrogen Receptor β modulates the response of breast cancer cells to therapeutic agents

2015 ◽  
Vol 66 ◽  
pp. 85-94 ◽  
Author(s):  
Daniel Gabriel Pons ◽  
Margalida Torrens-Mas ◽  
Mercedes Nadal-Serrano ◽  
Jorge Sastre-Serra ◽  
Pilar Roca ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Therapeutic Agents ◽  
Estrogen Receptor Β

19-Norvitamin D analogs for breast cancer therapy

2015 ◽  
Vol 93 (5) ◽  
pp. 333-348 ◽  
Author(s):  
Yotaro Matsumoto ◽  
Atsushi Kittaka ◽  
Tai C. Chen
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Functional Group ◽  
Active Form ◽  
Therapeutic Agents ◽  
Hydrogen Atoms ◽  
Breast Cancer Therapy ◽  
Dihydroxyvitamin D ◽  
Anti Tumor Activity

The active form of vitamin D3, 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3 or calcitriol), is known to inhibit the proliferation and invasiveness of many types of cancer cells, including breast, colon, pancreatic, prostate, and liver cancer cells. These findings support the use of 1α,25(OH)2D3 for the treatment of these types of cancer. However, 1α,25(OH)2D3 can cause hypercalcemia, so analogs of 1α,25(OH)2D3 that are less calcemic but exhibit more potent anti-tumor activity would be good candidates as therapeutic agents. Therefore, a series of 19-norvitamin D analogs, in which the methylidene group on C19 is replaced with 2 hydrogen atoms, have been synthesized by several laboratories. In our laboratory, we have designed and synthesized a series of 2α-functional group substituted 19-norvitamin D3 analogs and examined their anti-proliferative activity. Among them, 2α- and 2β-(3-hydroxypropyl)-1α,25-dihydroxy-19-norvitamin D3 (MART-10 and MART-11) were found to be the most promising. Here, we review the rationale and approaches for the synthesis of different 19-norvitamin D analogs, and the pre-clinical studies using these analogs in breast cancer cells, in particular, we chose MART-10 for its potential application to the prevention and treatment of breast cancer.

scholarly journals Needle-shaped amphoteric calix[4]arene as a magnetic nanocarrier for simultaneous delivery of anticancer drugs to the breast cancer cells

2019 ◽  
Vol Volume 14 ◽  
pp. 2619-2636 ◽  
Author(s):  
Mahdi Rahimi ◽  
Ramin Karimian ◽  
Ehsan Bahojb Noruzi ◽  
Khudaverdi Ganbarov ◽  
Mojtaba Zarei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Breast Cancer Cells ◽  
Simultaneous Delivery
Sign in / Sign up

Export Citation Format

Share Document