scholarly journals Marine natural products

2016 ◽  
Vol 33 (3) ◽  
pp. 382-431 ◽  
Author(s):  
John W. Blunt ◽  
Brent R. Copp ◽  
Robert A. Keyzers ◽  
Murray H. G. Munro ◽  
Michèle R. Prinsep
Keyword(s):  
Natural Products ◽  
Absolute Configuration ◽  
Marine Natural Products ◽  
New Compounds

This review of marine natural products for 2014 describes 1378 new compounds and reports structural revisions or assignments of absolute configuration for previously reported compounds. Since 1965 MNP chemists have made ∼9000 collections worldwide yielding ∼25 700 new MNPs. The rate of discovery of MNPs by region is examined in this review.

scholarly journals Marine natural products

2017 ◽  
Vol 34 (3) ◽  
pp. 235-294 ◽  
Author(s):  
John W. Blunt ◽  
Brent R. Copp ◽  
Robert A. Keyzers ◽  
Murray H. G. Munro ◽  
Michèle R. Prinsep
Keyword(s):  
Natural Products ◽  
Absolute Configuration ◽  
Marine Natural Products ◽  
Cancer Drug ◽  
Anti Cancer ◽  
New Compounds

This review of marine natural products for 2015 describes 1340 new compounds and reports structural revisions or assignments of absolute configuration for previously reported compounds. Other aspects of marine natural products research over the three sesquidecades from 1971 are also examined and contrasted against the 2015 discovery of the source of ET-743, also known as the anti-cancer drug Yondelis®(trabectedin).

scholarly journals Marine natural products

2015 ◽  
Vol 32 (2) ◽  
pp. 116-211 ◽  
Author(s):  
John W. Blunt ◽  
Brent R. Copp ◽  
Robert A. Keyzers ◽  
Murray H. G. Munro ◽  
Michèle R. Prinsep
Keyword(s):  
Clinical Trials ◽  
Natural Products ◽  
Phase I ◽  
Marine Natural Products ◽  
Rapid Development ◽  
Phase I Clinical Trials ◽  
New Compounds

This review of marine natural products for 2013 describes 1137 new compounds and reports structural revisions and assignments of absolute configurations for previously described compounds. Included is a report of the anticancer sponge metabolite PM060184 that has undergone a remarkably rapid development from discovery in 2005 to the commencement of phase I clinical trials in 2011.

scholarly journals Marine natural products

2018 ◽  
Vol 35 (1) ◽  
pp. 8-53 ◽  
Author(s):  
John W. Blunt ◽  
Anthony R. Carroll ◽  
Brent R. Copp ◽  
Rohan A. Davis ◽  
Robert A. Keyzers ◽  
...  
Keyword(s):  
Natural Products ◽  
Absolute Configuration ◽  
Marine Natural Products ◽  
Biological Activities ◽  
Chemical Diversity ◽  
Structure Revision ◽  
Approved Drugs

This review of 2016 literature describes the structures and biological activities of 1277 new marine natural products and the structure revision and absolute configuration of previously reported MNPs. The chemical diversity of 28 609 MNPs reported since 1957 is also investigated and compared to that of approved drugs.

Chemical and Bioactive Marine Natural Products of Coral-Derived Microorganisms (2015-2017)

2019 ◽  
Vol 26 (38) ◽  
pp. 6930-6941 ◽  
Author(s):  
Xue-Mei Hou ◽  
Yang Hai ◽  
Yu-Cheng Gu ◽  
Chang-Yun Wang ◽  
Chang-Lun Shao
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Pathogenic Bacteria ◽  
Tumor Cell Lines ◽  
Biological Targets ◽  
Wide Range ◽  
New Compounds ◽  
Novel Products

: Coral-derived microorganisms are known for their inherent ability to produce novel products of pharmaceutical importance. Nearly 260 marine natural products (MNPs) have been isolated from coral-derived microorganisms till 2014. In the last three years, 118 MNPs have been isolated from coral-associated microorganisms including 46 new compounds, two with a novel skeleton, and four new natural products. Most of them exhibited in vitro or in vivo activities against tumor cell lines, parasites, pathogenic bacteria, fungi and virus. We reviewed the natural products reported from 2015 to 2017 that have a wide range of bioactivities against different biological targets.

scholarly journals Biotechnological potential of marine natural products

2010 ◽  
Vol 82 (1) ◽  
pp. 17-26 ◽  
Author(s):  
Nobuhiro Fusetani
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Marine Sponges ◽  
Marine Organisms ◽  
Biotechnological Potential ◽  
Significant Potential ◽  
Modes Of Action ◽  
New Compounds ◽  
Research Tools

The number of marine natural products (MNPs) that have been applied to biotechnological industry is very limited, although nearly 20 000 new compounds were discovered from marine organisms since the birth of MNPs in the early 1970s. However, it is apparent that they have a significant potential as pharmaceuticals, cosmetics, nutraceuticals, research tools, and others. This article focuses on selective antitumor metabolites isolated from marine sponges and tunicates and their modes of action, as well as promising candidates for nontoxic antifoulants discovered from marine organisms.

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