Advances in identification and validation of protein targets of natural products without chemical modification

2016 ◽  
Vol 33 (5) ◽  
pp. 719-730 ◽  
Author(s):  
J. Chang ◽  
Y. Kim ◽  
H. J. Kwon
Keyword(s):  
Natural Products ◽  
Chemical Modification ◽  
Case Studies ◽  
Protein Identification ◽  
Target Protein ◽  
Label Free ◽  
Protein Targets ◽  
Identification Methods ◽  
Drug Candidates ◽  
New Drug

This review focuses on and reports case studies of the latest advances in target protein identification methods for label-free natural products. The integration of newly developed technologies will provide new insights and highlight the value of natural products for use as biological probes and new drug candidates.

Antitubercular Marine Natural Products

2018 ◽  
Vol 25 (20) ◽  
pp. 2304-2328 ◽  
Author(s):  
Lishu Wang ◽  
Jungfeng Wang ◽  
Juan Liu ◽  
Yonghong Liu
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Antitubercular Activity ◽  
Marine Resources ◽  
Drug Candidates ◽  
New Drug ◽  
Chemical Constitution

Due to the importance of nature as a source of new drug candidates, the purpose of this article is to emphasize the marine natural products, which exhibit antitubercular activity, published between January 2000 and May 2016, with 138 quotations to 250 compounds obtained from marine resources. These metabolites are organized by chemical constitution and named as simple alkyl lipids derivatives, aromatics derivatives, peptides, alkaloids, terpenoids, steroids, macrolides, and polycyclic polyketides.

Natural Products in the Process of Finding New Drug Candidates

2004 ◽  
Vol 11 (11) ◽  
pp. 1375-1389 ◽  
Author(s):  
P. Vuorela ◽  
M. Leinonen ◽  
P. Saikku ◽  
P. Tammela ◽  
J.- Rauha ◽  
...  
Keyword(s):  
Natural Products ◽  
Drug Candidates ◽  
New Drug

The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders I: Parkinsons Disease

2011 ◽  
Vol 10 (2) ◽  
pp. 239-250 ◽  
Author(s):  
Helineide Cristina Campos ◽  
Miguel Divino da Rocha ◽  
Flavia Pereira Dias Viegas ◽  
Patricia Carolina Nicastro ◽  
Poliana Calve Fossaluzza ◽  
...  
Keyword(s):  
Natural Products ◽  
Neurodegenerative Disorders ◽  
Parkinsons Disease ◽  
Drug Candidates ◽  
New Drug

scholarly journals Marine Natural Products Against Tuberculosis

2006 ◽  
Vol 6 ◽  
pp. 847-861 ◽  
Author(s):  
Marcus Vinícius Nora De Souza
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Human Diseases ◽  
Antituberculosis Activity ◽  
Drug Candidates ◽  
New Drug

Natural products represent an outstanding source of compounds that play an important role in the treatment of human diseases. Due to the importance of nature as a source of new drug candidates, the aim of this review is to highlight the marine natural products, which exhibit antituberculosis activity, discovered between 2000 and 2005.

The Role of Natural Products in the Discovery of New Drug Candidates for the Treatment of Neurodegenerative Disorders II: Alzheimers Disease

2011 ◽  
Vol 10 (2) ◽  
pp. 251-270 ◽  
Author(s):  
Miguel Divino da Rocha ◽  
Flavia Pereira Dias Viegas ◽  
Helineide Cristina Campos ◽  
Patricia Carolina Nicastro ◽  
Poliana Calve Fossaluzza ◽  
...  
Keyword(s):  
Natural Products ◽  
Neurodegenerative Disorders ◽  
Alzheimers Disease ◽  
Drug Candidates ◽  
New Drug

Current Approaches to Drug Discovery for Chagas Disease: Methodological Advances

2019 ◽  
Vol 22 (8) ◽  
pp. 509-520
Author(s):  
Cauê B. Scarim ◽  
Chung M. Chin
Keyword(s):  
Drug Discovery ◽  
Chagas Disease ◽  
Drug Candidates ◽  
Lead Compounds ◽  
New Drug ◽  
Compound Libraries ◽  
Screening Assays ◽  
Cruzi Infection

Background: In recent years, there has been an improvement in the in vitro and in vivo methodology for the screening of anti-chagasic compounds. Millions of compounds can now have their activity evaluated (in large compound libraries) by means of high throughput in vitro screening assays. Objective: Current approaches to drug discovery for Chagas disease. Method: This review article examines the contribution of these methodological advances in medicinal chemistry in the last four years, focusing on Trypanosoma cruzi infection, obtained from the PubMed, Web of Science, and Scopus databases. Results: Here, we have shown that the promise is increasing each year for more lead compounds for the development of a new drug against Chagas disease. Conclusion: There is increased optimism among those working with the objective to find new drug candidates for optimal treatments against Chagas disease.

Molecular Topological Properties of Alkylating Agents Based Anticancer Drug Candidates Via Some Ve-degree Topological Indices

2020 ◽  
Vol 16 (2) ◽  
pp. 190-195 ◽  
Author(s):  
Süleyman Ediz ◽  
Murat Cancan
Keyword(s):  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Alkylating Agents ◽  
Topological Indices ◽  
Pharmacological Properties ◽  
Topological Properties ◽  
Drug Candidates ◽  
New Drug ◽  
Atom Bond ◽  
Dual Target

Background: Reckoning molecular topological indices of drug structures gives the data about the underlying topology of these drug structures. Novel anticancer drugs have been leading by researchers to produce ideal drugs. Materials and Methods: Pharmacological properties of these new drug agents explored by utilizing simulation strategies. Topological indices additionally have been utilized to research pharmacological properties of some drug structures. Novel alkylating agents based anticancer drug candidates and ve-degree molecular topological indices have been introduced recently. Results and Conclusion: In this study we calculate ve-degree atom-bond connectivity, harmonic, geometric-arithmetic and sum-connectivity molecular topological indices for the newly defined alkylating agents based dual-target anticancer drug candidates.

Investigations on T cell transmigration in a human skin-on-chip (SoC) model

Lab on a Chip ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 1527-1539
Author(s):  
Xiaoou Ren ◽  
Anthony E. Getschman ◽  
Samuel Hwang ◽  
Brian F. Volkman ◽  
Thomas Klonisch ◽  
...  
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Human Skin ◽  
Drug Candidates ◽  
New Drug ◽  
Human T Lymphocytes ◽  
Quantitative Studies ◽  
Inflammatory Skin ◽  
Skin Conditions ◽  
On Chip

Our skin-on-chip (SoC) model uniquely enabled quantitative studies of transendothelial and transepithelial migration of human T lymphocytes under mimicked inflammatory skin conditions and was used to test new drug candidates.

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