Design, synthesis and relaxation studies of triazole linked gadolinium(iii)–DO3A-BT-bistriazaspirodecanone as a potential MRI contrast agent

2016 ◽  
Vol 40 (7) ◽  
pp. 5846-5854 ◽  
Author(s):  
Raunak Varshney ◽  
Swarndeep K. Sethi ◽  
Sandhya Rangaswamy ◽  
Anjani K. Tiwari ◽  
Marilyn D. Milton ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Facile Synthesis ◽  
Design Synthesis ◽  
Mri Contrast ◽  
Relaxation Studies

Novel and facile synthesis of a triazole based bisconjugated triazaspirodecanone as a potential MRI contrast agent.

Facile synthesis of zwitterionic polyglycerol dendrimers with a β-cyclodextrin core as MRI contrast agent carriers

2016 ◽  
Vol 7 (41) ◽  
pp. 6354-6362 ◽  
Author(s):  
Yuxin Han ◽  
Yue Qian ◽  
Xiaoxuan Zhou ◽  
Hongjie Hu ◽  
Xiangrui Liu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Synthesis Method ◽  
Mri Contrast Agent ◽  
Facile Synthesis ◽  
Mri Contrast ◽  
Imaging Probe ◽  
Polyglycerol Dendrimers

A facile synthesis method of a zwitterionic polyglycerol dendrimer was developed, providing an ideal carrier for drug and imaging probe delivery.

scholarly journals Design, synthesis, and evaluation of VEGFR-targeted macromolecular MRI contrast agent based on biotin–avidin-specific binding

2017 ◽  
Vol Volume 12 ◽  
pp. 5039-5052 ◽  
Author(s):  
Yongjun Liu ◽  
Xiaoyun Wu ◽  
Xiaohe Sun ◽  
Dan Wang ◽  
Ying Zhong ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Specific Binding ◽  
Mri Contrast Agent ◽  
Design Synthesis ◽  
Mri Contrast ◽  
Agent Based

scholarly journals Evaluation of non-targeting, C- or N-pH (low) insertion peptide modified superparamagnetic iron oxide nanoclusters for selective MRI of liver tumors and their potential toxicity in cirrhosis

RSC Advances ◽  
2019 ◽  
Vol 9 (25) ◽  
pp. 14051-14059
Author(s):  
Abdulrahman Ahmed Mahmood ◽  
Jianqi Zhang ◽  
Rufang Liao ◽  
Xiwei Pan ◽  
Dan Xu ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Liver Cancer ◽  
Contrast Agent ◽  
Cancer Diagnosis ◽  
Liver Tumors ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agent ◽  
Potential Toxicity ◽  
Mri Contrast ◽  
Specific Enhancement

The acid-responsive pHLIP modified SPION as an MRI contrast agent for liver cancer diagnosis requires the validation of both the tumor-specific enhancement and a safe profile in cirrhosis.

Gd2O3 nanoparticles as a positive MRI contrast agent for cell uptake

2010 ◽  
Author(s):  
N. Riyahi-Alam ◽  
J. Behrouzkia ◽  
S. Haghgoo ◽  
A Seifalian ◽  
R Zohdi Aghdam. ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Mri Contrast Agent ◽  
Cell Uptake ◽  
Mri Contrast ◽  
Gd2o3 Nanoparticles

scholarly journals Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1235
Author(s):  
Xiaohui Nan ◽  
Wenjia Lai ◽  
Dan Li ◽  
Jiesheng Tian ◽  
Zhiyuan Hu ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Magnetic Domain ◽  
Bilayer Membrane ◽  
The Body ◽  
Mri Contrast Agent ◽  
Mri Imaging ◽  
Mri Contrast

Derived from magnetotactic bacteria (MTB), magnetosomes consist of magnetite crystals enclosed within a lipid bilayer membrane and are known to possess advantages over artificially synthesized nanoparticles because of the narrow size distribution, uniform morphology, high purity and crystallinity, single magnetic domain, good biocompatibility, and easy surface modification. These unique properties have increasingly attracted researchers to apply bacterial magnetosomes (BMs) in the fields of biology and medicine as MRI imaging contrast agents. Due to the concern of biosafety, a long-term follow-up of the distribution and clearance of BMs after entering the body is necessary. In this study, we tracked changes of BMs in major organs of mice up to 135 days after intravenous injection using a combination of several techniques. We not only confirmed the liver as the well-known targeted organs of BMs, but also found that BMs accumulated in the spleen. Besides, two major elimination paths, as well as the approximate length of time for BMs to be cleared from the mice, were revealed. Together, the results not only confirm that BMs have high biocompatibility, but also provide a long-term in-vivo assessment which may further help to forward the clinical applications of BMs as an MRI contrast agent.

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