An efficient synthesis of 2,4,7-trisubstituted pyrimido[1,2-a][1,3,5]triazin-6-ones

2015 ◽  
Vol 39 (6) ◽  
pp. 4796-4804 ◽  
Author(s):  
Nikhil Sachdeva ◽  
Anton V. Dolzhenko ◽  
Seow Joo Lim ◽  
Wee Ling Ong ◽  
Wai Keung Chui
Keyword(s):  
Biological Activity ◽  
Efficient Synthesis ◽  
Practical Synthesis ◽  
Theoretical Assessment

A practical synthesis of 3,4-dihydro pyrimido[1,2-a][1,3,5]triazin-6-ones, experimental and theoretical assessment of their tautomeric preferences and biological activity results are presented.

Efficient synthesis of unsymmetrical heteroaryl thioethers and chalcogenides by alkali hydroxide-mediated SNAr reactions of heteroaryl halides and dichalcogenides

RSC Advances ◽  
2016 ◽  
Vol 6 (62) ◽  
pp. 56930-56935 ◽  
Author(s):  
Xiantao Ma ◽  
Quan Liu ◽  
Xiaojuan Jia ◽  
Chenliang Su ◽  
Qing Xu
Keyword(s):  
Efficient Synthesis ◽  
Practical Synthesis ◽  
Alkali Hydroxide

An efficient SNAr reaction of heteroaryl halides and diorganyl dichalcogenides is developed for practical synthesis of the useful unsymmetrical heteroaryl thioethers and chalcogenides.

Efficient synthesis of 3-O-thia-cPA and preliminary analysis of its biological activity toward autotaxin

2011 ◽  
Vol 21 (14) ◽  
pp. 4180-4182 ◽  
Author(s):  
Ryo Tanaka ◽  
Masaru Kato ◽  
Takahiro Suzuki ◽  
Atsuo Nakazaki ◽  
Emi Nozaki ◽  
...  
Keyword(s):  
Biological Activity ◽  
Preliminary Analysis ◽  
Efficient Synthesis

scholarly journals Synthesis and Anti-HIV Activity of Carbamates of Antiviral Agent Stavudine

2002 ◽  
Vol 13 (5) ◽  
pp. 289-297
Author(s):  
TK Venkatachalam ◽  
P Samuel ◽  
IV Kourinov ◽  
FM Uckun
Keyword(s):  
Biological Activity ◽  
Antiviral Agent ◽  
Heterocyclic Amines ◽  
Efficient Synthesis ◽  
Hiv Replication ◽  
Derivatives Of ◽  
Anti Hiv

An efficient synthesis of carbamate analogues of the NRTI compound stavudine, has been achieved in five steps starting from commercially available thymidine. The synthesis involves conversion of thymidine into stavudine followed by condensation with carbaimidazole derivative obtained from various aromatic and heterocyclic amines in dimethylformamide solvent. The analogues thus obtained were further purified by crystallization to furnish analytically pure products. Examination of biological activity of these carbamate derivatives of stavudine showed that they inhibited HIV replication only at micro-molar concentrations.

ChemInform Abstract: Efficient Synthesis of 3-O-Thia-cPA and Preliminary Analysis of Its Biological Activity Toward Autotaxin.

ChemInform ◽  
2011 ◽  
Vol 42 (47) ◽  
pp. no-no
Author(s):  
Ryo Tanaka ◽  
Masaru Kato ◽  
Takahiro Suzuki ◽  
Atsuo Nakazaki ◽  
Emi Nozaki ◽  
...  
Keyword(s):  
Biological Activity ◽  
Preliminary Analysis ◽  
Efficient Synthesis
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