Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand

Metallomics ◽  
2015 ◽  
Vol 7 (11) ◽  
pp. 1508-1514 ◽  
Author(s):  
Huiru Lu ◽  
Shenghui Li ◽  
Jun Chen ◽  
Jing Xia ◽  
Jinchao Zhang ◽  
...  
Keyword(s):  
Metal Ions ◽  
Small Molecule ◽  
G Quadruplex ◽  
Small Molecule Ligand

Abstract 2310: Down-regulating BCL-2 gene expression in a resistant GIST cell line by a RNA G-quadruplex interacting small molecule ligand

2011 ◽  
Author(s):  
Gary N. Parkinson ◽  
Mekala Gunaratnam ◽  
Xiong Wei Li ◽  
Gavin Collie ◽  
Anthony P. Reszka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Line ◽  
Small Molecule ◽  
G Quadruplex ◽  
Small Molecule Ligand

On the propagation of errors

2013 ◽  
Vol 69 (10) ◽  
pp. 1865-1866 ◽  
Author(s):  
Mariusz Jaskolski
Keyword(s):  
Protein Data Bank ◽  
Small Molecule ◽  
Data Bank ◽  
Propagation Of Errors ◽  
Small Molecule Ligand

The policy of the Protein Data Bank (PDB) that the first deposition of a small-molecule ligand, even with erroneous atom numbering, sets a precedent over accepted nomenclature rules is disputed. Recommendations regarding ligand molecules in the PDB are suggested.

scholarly journals Kinetic Target‐Guided Synthesis of Small‐Molecule G‐Quadruplex Stabilizers

ChemistryOpen ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1236-1250
Author(s):  
Alice Pomeislová ◽  
Lukáš Vrzal ◽  
Jaroslav Kozák ◽  
Juraj Dobiaš ◽  
Martin Hubálek ◽  
...  
Keyword(s):  
Small Molecule ◽  
G Quadruplex

Metalloenzyme-mimic innate G-quadruplex DNAzymes using directly coordinated metal ions as active centers

2020 ◽  
Vol 49 (37) ◽  
pp. 13160-13166
Author(s):  
Yali Yu ◽  
Qingqing Zhang ◽  
Heng Gao ◽  
Chenxiao Yan ◽  
Xiong Zheng ◽  
...  
Keyword(s):  
Metal Ions ◽  
Metal Ion ◽  
Active Centers ◽  
G Quadruplex

Metal ion-coordinated G-quadruplexes were first demonstrated to behave like metalloenzymes using directly complexed metal ions as the active centers.

scholarly journals Molecular Recognition of the Hybrid-Type G-Quadruplexes in Human Telomeres

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1578 ◽  
Author(s):  
Guanhui Wu ◽  
Luying Chen ◽  
Wenting Liu ◽  
Danzhou Yang
Keyword(s):  
Small Molecule ◽  
Solution Structure ◽  
Structural Information ◽  
Rational Drug Design ◽  
Hybrid Type ◽  
G4 Dna ◽  
Rational Drug ◽  
G Quadruplex ◽  
Molecule Recognition ◽  
Dna Secondary Structures

G-quadruplex (G4) DNA secondary structures formed in human telomeres have been shown to inhibit cancer-specific telomerase and alternative lengthening of telomere (ALT) pathways. Thus, human telomeric G-quadruplexes are considered attractive targets for anticancer drugs. Human telomeric G-quadruplexes are structurally polymorphic and predominantly form two hybrid-type G-quadruplexes, namely hybrid-1 and hybrid-2, under physiologically relevant solution conditions. To date, only a handful solution structures are available for drug complexes of human telomeric G-quadruplexes. In this review, we will describe two recent solution structural studies from our labs. We use NMR spectroscopy to elucidate the solution structure of a 1:1 complex between a small molecule epiberberine and the hybrid-2 telomeric G-quadruplex, and the structures of 1:1 and 4:2 complexes between a small molecule Pt-tripod and the hybrid-1 telomeric G-quadruplex. Structural information of small molecule complexes can provide important information for understanding small molecule recognition of human telomeric G-quadruplexes and for structure-based rational drug design targeting human telomeric G-quadruplexes.

Abstract 3089: A novel G-quadruplex formed in the PDGFR-β promoter that is selectively targeted by a small molecule to repress transcription

2016 ◽  
Author(s):  
Buket Onel ◽  
Prashansa Agrawal ◽  
Megan Carver ◽  
Robert Brown ◽  
Laurence Hurley ◽  
...  
Keyword(s):  
Small Molecule ◽  
G Quadruplex

Abstract 322: Selective inhibition of MYC expression by a small molecule G-quadruplex stabilizer

2016 ◽  
Author(s):  
Elena C. Leon ◽  
John K. Simmons ◽  
David Calabrese ◽  
Wendy DuBois ◽  
Kenneth Felsenstein ◽  
...  
Keyword(s):  
Small Molecule ◽  
Selective Inhibition ◽  
G Quadruplex
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